Next Generation Sequencing - Prof. Frans Cremers
Next Generation Sequencing - Prof. Frans Cremers
Next Generation Sequencing - Prof. Frans Cremers
Next Generation Sequencing - Prof. Frans Cremers
Next Generation Sequencing - Prof. Frans Cremers
Next Generation Sequencing - Prof. Frans Cremers
Next Generation Sequencing - Prof. Frans Cremers
Next Generation Sequencing - Prof. Frans Cremers
Next Generation Sequencing - Prof. Frans Cremers
Next Generation Sequencing - Prof. Frans Cremers
Next Generation Sequencing - Prof. Frans Cremers
Next Generation Sequencing - Prof. Frans Cremers
Next Generation Sequencing - Prof. Frans Cremers
Next Generation Sequencing - Prof. Frans Cremers
Next Generation Sequencing - Prof. Frans Cremers
Next Generation Sequencing - Prof. Frans Cremers
Next Generation Sequencing - Prof. Frans Cremers
Next Generation Sequencing - Prof. Frans Cremers
Next Generation Sequencing - Prof. Frans Cremers
Next Generation Sequencing - Prof. Frans Cremers
Next Generation Sequencing - Prof. Frans Cremers
Next Generation Sequencing - Prof. Frans Cremers
Next Generation Sequencing - Prof. Frans Cremers
Next Generation Sequencing - Prof. Frans Cremers
Next Generation Sequencing - Prof. Frans Cremers
Next Generation Sequencing - Prof. Frans Cremers
Next Generation Sequencing - Prof. Frans Cremers
Next Generation Sequencing - Prof. Frans Cremers
Next Generation Sequencing - Prof. Frans Cremers
Next Generation Sequencing - Prof. Frans Cremers
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Next Generation Sequencing - Prof. Frans Cremers

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Lecture for Bachelor Students

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  • Many monogenetic diseases have more than one possible underlying gene Complex monogenic disorders Number of genes varies a lot For some diseases no routine diagnostics available, since there are too many genes to be tested Medical need to sequence more! Limitations in Sequencing capacities + front end methods, i.e. enrichment BUT: technical limitations Definite need for novel (non-PCR based) front-end methods! Capillary (Sanger) Sequencing: 96/384-well, i.e. ~50-400 kb output/run
  • Many monogenetic diseases have more than one possible underlying gene Complex monogenic disorders Number of genes varies a lot For some diseases no routine diagnostics available, since there are too many genes to be tested Medical need to sequence more! Limitations in Sequencing capacities + front end methods, i.e. enrichment BUT: technical limitations Definite need for novel (non-PCR based) front-end methods! Capillary (Sanger) Sequencing: 96/384-well, i.e. ~50-400 kb output/run
  • Many monogenetic diseases have more than one possible underlying gene Complex monogenic disorders Number of genes varies a lot For some diseases no routine diagnostics available, since there are too many genes to be tested Medical need to sequence more! Limitations in Sequencing capacities + front end methods, i.e. enrichment BUT: technical limitations Definite need for novel (non-PCR based) front-end methods! Capillary (Sanger) Sequencing: 96/384-well, i.e. ~50-400 kb output/run
  • Many monogenetic diseases have more than one possible underlying gene Complex monogenic disorders Number of genes varies a lot For some diseases no routine diagnostics available, since there are too many genes to be tested Medical need to sequence more! Limitations in Sequencing capacities + front end methods, i.e. enrichment BUT: technical limitations Definite need for novel (non-PCR based) front-end methods! Capillary (Sanger) Sequencing: 96/384-well, i.e. ~50-400 kb output/run
  • Many monogenetic diseases have more than one possible underlying gene Complex monogenic disorders Number of genes varies a lot For some diseases no routine diagnostics available, since there are too many genes to be tested Medical need to sequence more! Limitations in Sequencing capacities + front end methods, i.e. enrichment BUT: technical limitations Definite need for novel (non-PCR based) front-end methods! Capillary (Sanger) Sequencing: 96/384-well, i.e. ~50-400 kb output/run
  • Many monogenetic diseases have more than one possible underlying gene Complex monogenic disorders Number of genes varies a lot For some diseases no routine diagnostics available, since there are too many genes to be tested Medical need to sequence more! Limitations in Sequencing capacities + front end methods, i.e. enrichment BUT: technical limitations Definite need for novel (non-PCR based) front-end methods! Capillary (Sanger) Sequencing: 96/384-well, i.e. ~50-400 kb output/run
  • Many monogenetic diseases have more than one possible underlying gene Complex monogenic disorders Number of genes varies a lot For some diseases no routine diagnostics available, since there are too many genes to be tested Medical need to sequence more! Limitations in Sequencing capacities + front end methods, i.e. enrichment BUT: technical limitations Definite need for novel (non-PCR based) front-end methods! Capillary (Sanger) Sequencing: 96/384-well, i.e. ~50-400 kb output/run
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