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Acromegaly
 

Acromegaly

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    Acromegaly Acromegaly Presentation Transcript

    • ACROMEGALY By: Reagan Lee ANAT&PHYSIO HON.
    • WHAT IS ACROMEGALY? Greek Roots ACRO: Extremity MEGAL: Enlargement To know what acromegaly is you must first have an understanding of the Endocrine System because Acromegaly is an endocrine disorder. As you see from the roots of this word is has to do with GH (Growth Hormone) which is produce by the pituitary gland.
    • EPIDEMIOLOGY • Even though this seems like a wide world occurrence, it isn’t. It is 40-70 cases per million population. It is a very rare and somewhat complex disease.The usually occurrence within a lifespan is the third decade of life.The signs and symptoms show up around 5-15 years of age. It could complicate and cause early death if not handled correctly.It usually doesn’t complicate the latter years of life.
    • CAUSES OF ARCOMEGALY • Acromegaly is the hyper-production of GH by pituitary gland.There are sevaral common causes of Acromegaly but over 95% of all cases are cause by a pituitary ardenoma.This is a tumor on the pituitary gland. Another cause of this disease is caused by something outside of the pituitary gland but it is very rare.
    • SIGN & SYMPTOMS • Tall stature • Mild to moderate obesity (common) • Macrocephaly (may precede linear growth) • Headaches • Visual changes • Hypopituitarism • Soft tissue hypertrophy • Exaggerated growth of the hands and feet, with thick fingers and toes • Coarse facial features Frontal bossing Prognathism Hyperhidrosis Osteoarthritis (a late feature of IGF-I excess) Peripheral neuropathies (eg, carpel tunnel syndrome) Cardiovascular disease Benign tumors Endocrinopathies
    • SIGNS & SYMPTOMS (CONT’D) Doughy-feeling skin over the face and extremities Thick and hard nails Deepening of creases on the forehead and nasolabial folds Noticeably large pores Thick and edematous eyelids Enlargement of the lower lip and nose (the nose takes on a triangular configuration) Wide spacing of the teeth and prognathism Hyperpigmentation (40% of patients) Acanthosis nigricans (a small percentage of patients) Excessive eccrine and apocrine sweating Breast tissue becoming atrophic; galactorrhea High blood pressure Mitral valvular regurgitation Mild hirsutism (in women)
    • DIAGNOSES & TREATMENTS Diagnoses Magnetic resonance imaging (MRI): To image pituitary adenomas Computed tomography (CT) scanning:To evaluate the patient for pancreatic, adrenal, and ovarian tumors secreting GH/GHRH; use chest CT scans to evaluate for bronchogenic carcinoma secreting GH/GHRH Radiography:To demonstrate skeletal manifestations of GH/IGF-I excess Treatments There is no single treatment.Treatment revolves around reducing the negative effects as well as changing the excess of the GH. One way may be transsphenoidal surgery. This is where the surgery goes through your nose to remove the tumor sometimes the surgeon may not be able to get it all and this could cause constant elevated levels of GH
    • http://www.studyblue.com/notes/note/n/heent-disorders/deck/3523775 http://emedicine.medscape.com/article/925446-overview CITED PAGE http://pituitary.ucla.edu/body.cfm?id=89 http://www.mayoclinic.org/diseases- conditions/acromegaly/basics/definition/con-20019216 http://www.hopkinsmedicine.org/neurology_neurosurg ery/specialty_areas/pituitary_center/conditions/acrom egaly.html