This presentation was made available to certified trainers of Paradigm Insulin Pump. The animation was executed within PowerPoint. The images of the pumps were created in Photoshop. The menu windows were illustrated in Freehand and then copied into PowerPoint as editable drawings objects.

1. Paradigm 515/715 insert brochure graphic and branding language

3. Paradigm ® Insulin Pump 515/715 Holds 300 units Same as 712 Paradigm 515 Paradigm 715 Same size : new software Holds 176 units Same as 512

6. Main Menu Same Menu New Information Paradigm 512 / 712 Paradigm 515 / 715 Current Battery & Reservoir Status always displayed on Home Screen & in Menu Mode Main Menu Bolus Suspend Basal Prime Utilities Bolus MiniMed Main Menu Bolus Suspend Basal Prime Utilities Bolus

7. Bolus Menu Exciting New Features Paradigm 512 / 712 Paradigm 515 / 715 Bolus Wizard Set Up Two new features in Wizard Set up Bolus Menu Set Bolus Bolus History Bolus Wizard Set Up Max Bolus Dual/Square Bolus Easy Bolus BG Reminder MiniMed Bolus Menu Set Bolus Bolus History Bolus Wizard Set Up Max Bolus Dual/Square Bolus Easy Bolus BG Reminder Press

8. Enhanced Bolus Wizard ™ Calculator Expanded Setup Ranges Paradigm 515 / 715 Bolus Wizard Setup The set-up ranges have been expanded to better meet the needs of patients with very high and very low insulin requirements. Bolus Menu Set Bolus Bolus History Bolus Wizard Set Up Max Bolus Dual/Square Bolus Easy Bolus BG Reminder

9. Enhanced Bolus Wizard ™ Calculator Expanded Setup Ranges NOTE: The Bolus Wizard will now allow a bolus to be delivered when BG’s are below 70 mg/dL, after the user has Activated through a Warning message. 60-250 mg/dL 80-160 mg/dL Target BG 10-400 mg/dL/unit 10-250 mg/dL/unit Insulin Sensitivity 3-150 grams/unit 0.1-5.0 unit/exch 3-75 grams/unit 0.2-5.0 unit/exch Carbohydrate Ratios 515/715 512/712

10. Two New Features in the Bolus Wizard ™ Calculator B G Target: Active Insulin Time: BG Targets & Selectable Active Insulin Curves Paradigm 512 / 712 Paradigm 515 / 715 Edit Settings Wizard: Carb units: Carb Ratios: BG Units: Sensitivity: BG Target: Active Insulin Time: on grams 15 mg/dL 50 100 – 100 6 hrs. MiniMed Edit Settings Wizard: Carb units: Carb Ratios: BG Units: Sensitivity: BG Targets: on grams 15 mg/dL 50 100 2 New Programming Features

11. New Features in the Bolus Wizard ™ BG Targets B G Target: Edit Settings Wizard: Carb units: Carb Ratios: BG Units: Sensitivity: BG Target: Active Insulin Time: on grams 15 mg/dL 50 100 – 100 6 hrs. Press

13. BG Target Ranges Can Now be Programmed in BG Ranges! 150 80 If ranges are set below 90 or above 140 , a warning screen appears, just as a friendly reminder. TARGET RANGE 1 12:00A mg / L – 100 100

14. BG Target Ranges Reminder Message WARNING A target range of 80 to 150 is valid but outside the usual range of 90 to 140 ESC to correct. ACT to continue.

15. BG Targets Can Now be Programmed in BG Ranges If BG falls within the programmed range – NO Correction insulin is calculated. If BG falls above or below the programmed range – Correction insulin is calculated. Example BG Within Programmed Range BG: 82 mg/dL Example BG Below Programmed Range BG: 70 mg/dL Example BG Programmed Above Range BG: 150 mg/dL Negative Correction insulin is calculated. NO Correction is calculated. Correction insulin is calculated. TARGET RANGE 1 12:00A mg / dL 80 – 100

16. BG Below Target Range Negative Correction Insulin Calculated Food: Correction: Est total: Example BG Below Programmed Range BG: 70 mg/dL SF = 30 Carbs: 60 gms ICR = 15 70 – 80 = - 0.3U 30 NOTE: Corrects to lowest end of range. 60 = 4.0 15 gm Estimate Details Est total: 3.7U Food intake: 60 gm BG: 70 Food: 4.0U Correction: 0.3U Active ins: 0.0U ACT to proceed, ESC to back up – TARGET RANGE 1 12:00A mg / dL 80 – 100

17. BG Within Target Range No Correction Insulin Calculated – Food: Correction: Est total: Example BG Within Programmed Range BG: 82 mg/dL SF = 30 Carbs: 60 gms ICR = 15 BG is between 80 – 100 No correction calculated 60 = 4.0 15 gm Estimate Details Est total: 4.0U Food intake: 60 gm BG: 82 Food: 4.0U Correction: 0.0U Active ins: 0.0U ACT to proceed, ESC to back up TARGET RANGE 1 12:00A mg / dL 80 – 100

18. BG Above Target Range Positive Correction Insulin Calculated Example BG Above Programmed Range BG: 160 mg/dL SF = 30 Carbs: 60 gms ICR = 15 60 = 4.0 15 gm 160 – 100 = + 2.0U 30 NOTE: Corrects to highest end of set range. Food: Correction: Est total: Estimate Details Est total: 6.0U Food intake: 60 gm BG: 82 Food: 4.0U Correction: 2.0U Active ins: 0.0U ACT to proceed, ESC to back up TARGET RANGE 1 12:00A mg / dL 80 – 100

19. Adjustable Active Insulin Can be Individualized MiniMed Edit Settings Wizard: Carb units: Carb Ratios: BG Units: Sensitivity: BG Target: Active Insulin Time: on grams 15 mg/dL 50 100 – 100 6 hrs. Active Insulin Time: Can be adjusted in 1 hour increments from 2-8 hours. Press

20. Adjustable Active Insulin Default is set to 6 hours 6 hrs. is the length of time that most closely mimics the published information on insulin pharmacodynamics. ACTIVE INSULIN TIME 12:00A hr 6

21. Adjustable Active Insulin Curves

23. Basal Menu No Changes 0.05 Delivery 0.05 Delivery Paradigm 512 / 712 Paradigm 515 / 715 Exactly the same Features as found on 512 / 712 MiniMed BASAL MENU Set / Edit Temp Basal Set / Edit Basal Basal Review Max Basal Rate Patterns Temp Basal Type BASAL MENU Set / Edit Temp Basal Set / Edit Basal Basal Review Max Basal Rate Patterns Temp Basal Type

24. Prime Menu Simplified Choices Contains Only Options Specific to Reservoir Change “ Insulin Change” (Insulin type) Option has been removed. Paradigm 512 / 712 Paradigm 515 / 715 Insulin Change PRIME MENU Fixed Prime Rewind Prime History Insulin Change MiniMed PRIME MENU Fixed Prime Rewind Prime History Insulin Change

25. Utilities Menu Lock Keypad User Settings Daily Totals Expanded data management 2 New Optional Features 2 New Optional Features MiniMed UTILITIES MENU Alarm Daily Totals Time/Date Alarm Clock Remote Option Meter Options Block Selftest Clear Pump Language UTILITIES MENU Lock Keypad Alarm Daily Totals Time/Date Alarm Clock Meter Options Remote Options Block Selftest User Settings Language Press

28. User Settings Allows Patient to Save Basal Rates & all Bolus Wizard ™ Settings User Settings UTILITIES MENU Lock Keypad Alarm Daily Totals Time/Date Alarm Clock Meter Options Remote Options Block Selftest User Settings Language Press

29. User Settings Allows Patient to Save Settings This screen appears if ACT is pressed from the Utilities Menu. Press & The “User Settings” screen is only accessible when the & are pressed simultaneously. This feature is not normally accessible. To access, consult your User Guide.

31. User Settings Feature Pump Settings can be Cleared Clear Settings No Beep Beep Beep Beep Beep CLEAR CANCELLED User settings will NOT be cleared CONFIRM No Yes USER SETTINGS Save Settings Restore Settings Clear Settings History Press

33. User Settings Feature Pump Settings can be Restored Restore Settings SETTINGS RESTORED User settings have been restored PLEASE CHECK SETTINGS USER SETTINGS Save Settings Restore Settings Clear Settings History Press Press Press ACT to restore settings saved on 20APR2004 at 9:41A ESC to CANCEL

35. Backlight Always Available Paradigm ® Insulin Pump Enhancements USER SETTINGS Save Settings Restore Settings Clear Settings History USER SETTINGS Save Settings Restore Settings Clear Settings History The backlight can be turned on from any menu by pressing & simultaneously.

36. On-Pump Data Management Provides additional BG and insulin delivery data Daily Totals UTILITIES MENU Lock Keypad Alarm Daily Totals Time/Date Alarm Clock Meter Options Remote Options Block Selftest User Settings Language Press

37. On-Pump Data Management Provides MORE Information Detail can be viewed by day or by averages 26JUL 112.30U DAILY TOTALS Daily Average Today 0.00U 26JUL 112.30U Press

45. Medtronic CareLink  Therapy Management System for Diabetes Quick View Summary Report Trends Summary Report Modal Day Periods Report 8 Customizable Reports (3 samples displayed below)