In this study, the antioxidant capacity of OPC-3 in isotonix form was compared against OPC-3 in tablet form.
Isotonix OPC-3 reduces free radicals faster. OPC-3 in tablet form never quite equals antioxidant power of Isotonix OPC-3.
The Health Benefits of Isotonix OPC-3® Mark Lange, Ph.D. James Wilmer, Ph.D. Market America, Inc.
Statements have not beenevaluated by the Food and DrugAdministration. This product isnot intended to diagnose, treat, cure or prevent any disease.
Primary Benefits Although there are many potential uses for Isotonix OPC-3®, the most common are: Helps maintain normal, healthy circulation Helps promote cardiovascular health.
Pharmacological Actions Helps maintain normal blood glucose levels Supports normal platelet activity Powerful free radical scavenger Demonstartes anti-inflammatory action Supports healthy endothelial function
Serving SizeThe serving size for a healthy individualfor general health maintenance is given onthe label (one capful per day).Consult with your healthcare providerbefore taking additional servings per day.
Duration of UseMost people see the benefit of IsotonixOPC-3® within 8-12 weeks.Given Isotonix OPC-3’s long history of useby thousands of satisfied customers, nolimitation on length of use is indicated.
Quality of IngredientsIsotonix OPC-3® is blended using the finestingredients available. Each ingredient isaffirmed GRAS (generally recognized assafe), free of pesticide residue and incompliance with USP and FDArequirements for purity.
® Isotonix OPC-3 Contains ® PycnogenolPycnogenol is a proprietary extract of the Frenchmaritime pine bark.Pycnogenol contains oligomericproanthocyanidins (OPCs) as well as otherbioflavonoids.Only Isotonix products have Pycnogenol inisotonic delivery form.
Proanthocyanidins are found ingrape seed extract, pine bark and red wine.
How do OPCs Protect Tissue from Free Radical Attack? They donate electrons from the hydroxyl (–OH) group. Donated electron stabilizes (inactivates) free radicals. Then forms a stable intermediate that will not react with tissue. Vitamin C recycles (regenerates) OPCs’ antioxidant capability.
OPCs Help Protect Tissues and Cells Lipids, proteins and DNA are targets for free radical attack. Free radicals not only directly cause cell injury, they can also act as signals for pro- inflammatory pathways. Helps prevent oxidative stress in the human body.
Human Cells have fat-like and water-like regions; where water-soluble and fat-soluble antioxidants resideLipid bilayer (cell wall)Fat-like region CytoplasmWater-like region
OPC-3 and Cardiovascular Health ® Endothelial cells line the inner wall of blood vessels. Endothelial cell health is an important factor in cardiovascular health. The endothelium also helps control blood pressure through vasorelaxation. Pycnogenol stimulates nitric oxide production which promotes normal vasorelaxation (dilation of blood vessels).
Accelerated antioxidant bioavailability of OPC-3® bioflavonoids administered as isotonic solution Cesarone et al. Phytotherapy Research 23, 775-777(2009) 10 subjects (5 male, 5 female), 24-45 years, healthy, non-smokers with elevated plasma oxidative stress Subjects took: OPC-3 first in isotonic form, then 1 week later OPC-3 in tablet form (with equivalent water) Plasma antioxidant effect was monitored over a 4 hour period.
Isotonic OPC-3® versus OPC-3® in tablet form. Reduced plasma oxidative stress (increase in plasma radical reduction rate to baseline) within 10 minutes. Plasma free radical values always remained lower throughout the 4 hours. Biphasic absorption noted: first phase- rapid absorption and antioxidant effect from monomeric and dimeric species. second phase- may involve absorption of larger molecules, maximizing at 70 mins.
In this publication, the authors conclude: “In conclusion the findings demonstrate that the flavonoid mixture provided in isotonic OPC-3® is significantly more bioavailable in humans, in terms of antioxidant activity than an equivalent mixture in tablet form.”
Summary Isotonix OPC-3® provides isotonic delivery of Pycnogenol, along with other sources of active bioflavonoids. Isotonix OPC-3® promotes cardiovascular health and normal flood vessel function. Isotonix OPC-3® is a safe, all-natural supplement known for a wide range of health benefits.