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Isotonix opc 3


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  • In this study, the antioxidant capacity of OPC-3 in isotonix form was compared against OPC-3 in tablet form.
  • Isotonix OPC-3 reduces free radicals faster. OPC-3 in tablet form never quite equals antioxidant power of Isotonix OPC-3.
  • Transcript

    • 1. The Health Benefits of Isotonix OPC-3® Mark Lange, Ph.D. James Wilmer, Ph.D. Market America, Inc.
    • 2. Statements have not beenevaluated by the Food and DrugAdministration. This product isnot intended to diagnose, treat, cure or prevent any disease.
    • 3. Primary Benefits Although there are many potential uses for Isotonix OPC-3®, the most common are: Helps maintain normal, healthy circulation Helps promote cardiovascular health.
    • 4. Pharmacological Actions Helps maintain normal blood glucose levels Supports normal platelet activity Powerful free radical scavenger Demonstartes anti-inflammatory action Supports healthy endothelial function
    • 5. Serving SizeThe serving size for a healthy individualfor general health maintenance is given onthe label (one capful per day).Consult with your healthcare providerbefore taking additional servings per day.
    • 6. Duration of UseMost people see the benefit of IsotonixOPC-3® within 8-12 weeks.Given Isotonix OPC-3’s long history of useby thousands of satisfied customers, nolimitation on length of use is indicated.
    • 7. Quality of IngredientsIsotonix OPC-3® is blended using the finestingredients available. Each ingredient isaffirmed GRAS (generally recognized assafe), free of pesticide residue and incompliance with USP and FDArequirements for purity.
    • 8. ® Isotonix OPC-3 Contains ® PycnogenolPycnogenol is a proprietary extract of the Frenchmaritime pine bark.Pycnogenol contains oligomericproanthocyanidins (OPCs) as well as otherbioflavonoids.Only Isotonix products have Pycnogenol inisotonic delivery form.
    • 9. Proanthocyanidins are found ingrape seed extract, pine bark and red wine.
    • 10. How do OPCs Protect Tissue from Free Radical Attack? They donate electrons from the hydroxyl (–OH) group. Donated electron stabilizes (inactivates) free radicals. Then forms a stable intermediate that will not react with tissue. Vitamin C recycles (regenerates) OPCs’ antioxidant capability.
    • 11. OPCs Help Protect Tissues and Cells Lipids, proteins and DNA are targets for free radical attack. Free radicals not only directly cause cell injury, they can also act as signals for pro- inflammatory pathways. Helps prevent oxidative stress in the human body.
    • 12. Human Cells have fat-like and water-like regions; where water-soluble and fat-soluble antioxidants resideLipid bilayer (cell wall)Fat-like region CytoplasmWater-like region
    • 13. OPC-3 and Cardiovascular Health ® Endothelial cells line the inner wall of blood vessels. Endothelial cell health is an important factor in cardiovascular health. The endothelium also helps control blood pressure through vasorelaxation. Pycnogenol stimulates nitric oxide production which promotes normal vasorelaxation (dilation of blood vessels).
    • 14. Accelerated antioxidant bioavailability of OPC-3® bioflavonoids administered as isotonic solution Cesarone et al. Phytotherapy Research 23, 775-777(2009) 10 subjects (5 male, 5 female), 24-45 years, healthy, non-smokers with elevated plasma oxidative stress Subjects took:  OPC-3 first in isotonic form, then 1 week later OPC-3 in tablet form (with equivalent water) Plasma antioxidant effect was monitored over a 4 hour period.
    • 15. Isotonic OPC-3® versus OPC-3® in tablet form. Reduced plasma oxidative stress (increase in plasma radical reduction rate to baseline) within 10 minutes. Plasma free radical values always remained lower throughout the 4 hours. Biphasic absorption noted:  first phase- rapid absorption and antioxidant effect from monomeric and dimeric species.  second phase- may involve absorption of larger molecules, maximizing at 70 mins.
    • 16. OPC-3® isotonic formulation 3.0Plasma radical reduction rate OPC-3® tablet to baseline [units/min] 2.5 2.0 1.5 1.0 0.5 0.0 Start 10 20 30 40 50 60 70 80 90 120 150 180 210 240 Time after consumption [min]
    • 17. In this publication, the authors conclude: “In conclusion the findings demonstrate that the flavonoid mixture provided in isotonic OPC-3® is significantly more bioavailable in humans, in terms of antioxidant activity than an equivalent mixture in tablet form.”
    • 18. Summary Isotonix OPC-3® provides isotonic delivery of Pycnogenol, along with other sources of active bioflavonoids. Isotonix OPC-3® promotes cardiovascular health and normal flood vessel function. Isotonix OPC-3® is a safe, all-natural supplement known for a wide range of health benefits.