Peritonitis in peritoneal dialysis patients

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Peritonitis in peritoneal dialysis patients

  1. 1. Peritonitis in peritoneal dialysis patients Dr Cherelle Fitzclarence Renal GP July 2009
  2. 2. Overview  Peritoneal Dialysis - principles  Anatomy  Physiology  Pathology  Presentations  Management  Key points www.health.com/
  3. 3. Proteinuria CKD ESKD Care plan Care plan Care plan STAGE 1 & 2 STAGE 3 STAGE 4 STAGE 5 PALLIATIVE CARE Proteinuria plus eGFR 60+ eGFR 30-59 eGFR 15-29 eGFR <15 ml/min ml/min ml/min (to determine eGFR over 60, hand MODERATE SEVERE calculate GFR using KIDNEY KIDNEY FAILURE Cockcroft-Gault formula) DAMAGE DAMAGE DIALYSIS HAEMODIALYSIS PERITONEAL DIALYSIS TRANSPLANTATION GFR = (140 - Age) x wt (kg) Chronic se creat (mmol/Lt) End Stage Kidney Kidney Kidney Males = GFR x 1.23 Disease Failure Disease Diagnosis Diagnosis SUPPORTIVE CARE APPROACH
  4. 4. Peritoneal Dialysis  A form of renal replacement therapy for patients with end stage kidney disease  Endeavours to replace some of the functions of the kidney such as  Removing waste products  Removing excess fluid  Correcting acid/base imbalances www.agingdiscodiva.com  Correcting electrolyte imbalances  High maintenance form of therapy requiring meticulous compliance and effort on part of patient
  5. 5. IDEAL BODY WEIGHT IBW  Normotensive (Good BP) 120/70  No signs and symptoms of overload or dehydration  Set by:  Home Training Staff Royal Perth Hospital  Renal Doctor  Dialysis Staff KSDC
  6. 6. FLUID ASSESSMENT  Blood pressure  JVP  Weight  Skin tugor  Chest, SaO2, SOB  Symptoms  Oedema  Nausea,  Ankles vomiting  Back  Diarrhoea  Facial  Dizziness
  7. 7. FLUID RESTRICTION  800 – 1000 mls per day  Weigh patient (will be required daily – SAME SCALES and document which ones)  In hospital, remove jug
  8. 8. Peritoneal Dialysis  Involves the passage of solutes and water across a membrane that separates two fluid containing compartments-blood and dialysate  During dialysis 3 transport processes occur simultaneously  Diffusion  Ultrafiltration  Absorption http://www.dialyse-45.net/int/info/techniques.htm
  9. 9. Peritoneal Dialysis  2 types  CAPD – continuous ambulatory peritoneal dialysis  Involves on average 4 dwells per day of 4-8 hours of 2 – 2.5L each  APD – automated peritoneal dialysis  Involves 3-10 exchanges overnight of varying amounts  Usually but not always a daytime dwell
  10. 10. Peritoneal Dialysis  Anatomy  Serosal membrane lining the gut  Thought to be the same as the body surface area – usually 1-2 m2 in adult  2 parts – visceral peritoneum lining the organs (80% or the peritoneal surface area and the parietal peritoneum lining the walls of the abdominal cavity)  Peritoneal blood flow can’t be measured but indirectly estimated to be between 50-100mls/ min
  11. 11. Peritoneal Dialysis
  12. 12. Horizontal disposition of the peritoneum in the lower part of the abdomen. www.theodora.com/anatomy/the_abdomen.html
  13. 13. Peritoneal Dialysis  Visceral peritoneum blood supply is from the superior mesenteric with venous drainage from the portal system  Parietal peritoneum blood supply is from the lumbar, intercostal and epigastric arteries while the venous drainage is via the IVC  Main lymphatic drainage is via stomata in the diaphragmatic peritoneum which drain into the right lymphatic duct
  14. 14. Three pore model  Peritoneal capillary is the critical barrier to peritoneal transport  Movement of solute and water movement across the capillary is mediated by pores of three different sizes  Large pores 20-40 nm – protein transport  Small pores 4-6nm – small solutes eg urea, creatinine, sodium, potassium, water  Ultrapores (aquaporins) <0.8nm – transport of water
  15. 15. Three pore model of peritoneal transport Kidney International ISSN: 0085-2538 EISSN: 1523-1755 © 2009 International Society of Nephrology
  16. 16. Peritoneal Transport - Diffusion  Diffusion – uraemic solutes and potassium diffuse from peritoneal capillary blood into the dialysate. Glucose, lactate, bicarbonate and calcium diffuse in the opposite direction.  Diffusion depends on concentration gradient (maximal at the start), effective peritoneal surface area, intrinsic peritoneal membrane resistance, molecular weight of the solute (eg small molecules like urea, diffuse more rapidly than larger molecules such as creatinine)
  17. 17. Diffusion www.indiana.edu/.../lecture/lecnotes/diff.html
  18. 18. Peritoneal Transport - Ultrafiltration  Occurs as a consequence of the osmotic gradient between the hypertonic dialysate and the relatively hypotonic peritoneal capillary blood  Driven by high concentration of glucose in dialysate  Depends on;  concentration gradient of the osmotic agent (glucose)  peritoneal surface area  hydraulic conductance of the peritoneal membrane  reflection coefficient for the osmotic agent (how effectively the osmotic agent diffuses out of the dialysate into the peritoneal capillaries (0-1 is normal – the lower the value the faster the osmotic gradient is lost. Gluc is 0.3 as opposed to icodextrin which is close to 1)).  Hydrostatic pressure gradient – cap press around 20mm versus intraperitoneal pressure around 7mm Hg which favours ultrafiltration
  19. 19. Ultrafiltration http://www.dialysistips.com/principles.html
  20. 20. Peritoneal Transport – Ultrafiltration 2  Depends on;  Oncotic pressure gradient which acts to keep fluid in blood, opposing ultrafiltration (low in hypoalbuminaemic patients so ultrafiltration tends to be high)  Sieving – occurs when solute moves along with water across a semipermeable membrane by convection but some of the solute is held back – sieved. The solute concentration in the ultrafiltrate that has passed through the membrane is lower than the source solution. Different solutes sieve differently ranging from 0 (complete sieving) to 1 (no sieving)  Other osmotic agents such as icodextrin with a large reflection coefficient so ultrafiltration is sustained
  21. 21. Ultrafiltration http://www.advancedrenaleducation.com/PeritonealDialysis/Ultrafiltration/HowtoAchieveAdequatePDUF/tabid/229/Default.aspx
  22. 22. Peritoneal Transport – Fluid Absorption  Occurs via the lymphatics at constant rate  Typical values for peritoneal fluid absorption are 1-2 mls/minute  Affected by intraperitoneal hydrostatic pressure  Effectiveness of lymphatics http://www.fmc-ag.com/gb_2006/en/05/glossar.html
  23. 23. Peritonitis  Peritoneal Dialysis is a great form of renal replacement therapy  Peritonitis is a significant complication  Incidence peritonitis episodes varies from 1/9 patient-months to 1/53 patient-months (Grunberg 2005; Kawaguchi 1999)  Our figures pending but are likely to be on the lower end of the scale
  24. 24. Peritonitis in PD pts  Risk Factors  Diabetes  Non caucasian  Obesity  Temperate climate  Depression  Possibly the peritoneal dialysis modality but not proven (Huang 2001; Oo 2005). http:// www.diabetesandrelatedhealthissues.co m/
  25. 25. Peritonitis in PD pts  Significant morbidity  Some mortality - It is estimated that PD- associated peritonitis results in death in 6% of affected patients (Troidle 2006). gymsoap.com
  26. 26. Peritonitis in PD pts  Catheter removal may become necessary if pt is not responding to antibiotics or if infection is fungal. May be temporary or permanent  Ultrafiltration failure can occur both acutely due to increases in capillary permeability (Ates 2000; Smit 2004) and in the longer term resulting in technique failure (Coles 2000; Davies 1996).
  27. 27. Pathogenesis  1. Potential routes of infection  Intraluminal – improper technique; access to bacteria via the catheter lumen  Periluminal – bacteria present on skin surface enter the peritoneal cavity via the catheter tract  Transmural – bacteria of intestinal origin migrate through the bowel wall  Haematogenous – peritoneum seeded via the blood stream  Transvaginal - ??
  28. 28. Pathogenesis  2. Bacteria laden plaque – the intraperitoneal portion of the catheter is covered with a bacteria laden plaque - ? Role in pathogenesis of peritonitis  3. Host defences – peritoneal leucocytes critical in combating bacteria that have entered the peritoneum. Affected by  A. dialysis solution and ph – hypertonic solution inhibits activity  B. Calcium levels – low calcium in dialysate inhibits activity  Peritoneal IgG levels – low levels inhibit activity  HIV – little known effect
  29. 29. Aetiology  Staph aureus  Coag neg staph (S.Epidermidis)  E coli  Pseudomonas  Sternotropomonas  Candida  Atypical TB
  30. 30. Diagnosis  2 of the following 3 conditions  Symptoms and signs of peritoneal inflammation (pain, tenderness, guarding, rebound)  Cloudy peritoneal fluid with increased white cell count (specifically neutrophils)  Demonstration of bacteria on gram stain or culture
  31. 31. Diagnosis – symptoms and signs  Abdo pain most common but in a PD pt suspect peritonitis if general malaise, nausea, vomiting or diarrhoea  Don’t be blinded by the PD  These pts get other pathology  EG. Strangulated hernia, withdrawal from steroids (if they stop taking meds suddenly and they happen to be on steroids), ruptured viscus, ulcers, perforations etc  EXAMINE THE PATIENT
  32. 32. Diagnosis – symptoms and signs Percentage Symptoms Abdo pain 95 Nausea and vomiting 30 Fever 30 Chills 20 Constipation or diarrhoea 15 Signs Cloudy peritoneal fluid 99 Abdo tenderness 80 Rebound tenderness 10-50 Increased temperature 33 Blood leucocytosis 25 CRP 100 but can be delayed Daugirdas JT et al 2007 p 419
  33. 33. Diagnosis – peritoneal fluid  Cloudiness – when cell count greater than 100 x 106  Normal is around 10x106 but always less than 50x106  Mostly cloudiness means peritonitis but be aware of other causes such as fibrin, blood, malignancy, chyle  Don’t write peritonitis off as a diagnosis if everything else fits but the fluid is relatively clear – the changes can lag  Must get a WCC (peritoneal fluid) with specific neutrophil count. Neutrophils required as the total number of white cells can vary according to whether patient dry or wet etc. Normally predominant cells are mononuclears and neutrophils are usually less than 15% of total white cell count  Be aware of mimickers such as PID, ovulation, recent pelvic examination which may affect the cell counts in the peritoneal fluid
  34. 34. Peritoneal fluid culture  Send the whole bag  Label it (preferable with texta – label can sweat off)  Let the lab know it is coming  Ask for urgent gram stain and cell count and ask this to be telephoned to you. Be aware that the gram stain may be negative in 50% of cases of subsequent culture proven peritonitis  Also ask for M/C/S and fungal cultures  Follow up the culture  Do a full septic workup each time – including blood cultures
  35. 35. Peritonitis  Common things occur commonly and peritonitis is unfortunately common in our population of PD patients  BUT  Don’t lose sight of the bigger picture and these patients can suffer from any other pathology – always keep an open mind
  36. 36. Peritonitis Management  Broad spectrum coverage  Vancomycin (2.5g if more than 60kg / 2 g if 60kg or less)  Gentamicin (200mg if more than 60kg / 140mg if 60kg or less)  IP is better than IV (confirmed on large Cochrane review April 2009)  Await culture. If gram positive, then repeat the vanc dose in 1 week. If gram negative then usually ceftriaxone 1g intraperitoneally daily for 14 days  Things to note; if pseudomonas tube is very often lost. May need to consider adding a second antibiotic such as daily ciprofloxacin
  37. 37. PERITONITIS MANAGEMENT Initial symptoms may include; diarrhoea, vomiting, nausea, abdominal pain, mental confusion or feeling unwell COLLECT DRAINED BAG *See additional resources (pink section) for drainage instructions * Send entire bag for urgent MC&S (including WCC differential) and Fungal elements. **** Must ‘cc’ KRSS **** CLEAR BAG CLOUDY BAG Intraperitoneal (IP) Antibiotics (see Procedures) must be able to read newspaper print through Give BOTH the bag Gentamycin – 160mgs if 60kgs or less LOOK FOR OTHER CAUSES (gram –ve organisms) 200mg if > 60kgs Call PD Coordinator or AND Renal GP Vancomycin - 2gms if 60kgs or less (gram +ve organisms) 2.5grams if > 60kgs Give both in a 2L 2.3% bag ATTENTION: the abdomen for minimum 6 hours Dwell in (Consult microbiologist if Vanc or Gent allergy) Vanc and Gent provide some coverage while awaiting sensitivities. ****Further antibiotics WILL be required **** If Staph/gram +ve, give IP Vancomicin again on Day 7 If gram negative, refer to sensitivities, but usually 14 days of IP Ceftriaxone 1gm YOU MUST follow up the MC & S 48 hours after initial IP treatment. A WCC > 100 confirms peritonitis. If the patient is not improving within 24 hrs, or any other concerns, contact PD coordinator
  38. 38. Peritonitis Mx  CAPD/APD  Drain abdomen and send bag off with path request as above  Change the transfer set completely following usual aseptic techniques  Load 2.3% 2 litre dialysate bag (use 1.5% bag if patient hypotensive) with Vancomycin and Gentamicin as per above guideline  Infuse bag into peritoneum  6 hour dwell
  39. 39. Peritonitis – fungal infection  If fungal organisms are seen on gram stain, or cultured, it is unlikely you will be able to save the tube  Once the tube is colonized, the only cure is removal of tube, peritoneal rest (pt on Haemodialysis for a few months) and then start from scratch
  40. 40. Peritonitis  If you think that the patient has peritonitis but you think they have life threatening sepsis eg hypotension, tachycardia, fever (or no fever as may not be able to mount an immune response), altered conscious state etc, your patient is likely to require IV broad spectrum antibiotics. Ring the microbiologist on call. Don’t wait to get IP regime in. That can go in while you are making calls and obtaining results.  Antibiotics must be given within 1 hour of presentation – it is an emergency.  I usually ring SCGH as they maintain a 24 hour consultant micro roster 93463333 but remember all our patients who require transfer must go to Royal Perth Hospital as they are under the RPH consultant
  41. 41. Peritonitis  Patients can have dual pathology  Eg it is not uncommon for patients to have peritonitis, delay treatment, splint their abdomen and get pneumonia. This needs to be treated as per the normal guidelines for pneumonia
  42. 42. Peritonitis  Additives to bags  Vancomycin, aminoglycosides and cephalosporins are safe to mix in the same bag  Aminoglycosides are incompatible with penicillins  Vancomycin is stable for 28 days in dialysate (normal room temp)  Cefazolin is stable for 8 days  Gentamicin is stable for 14 days  Heparin added decreases duration of stability
  43. 43. Peritonitis  Often get formation of fibrin clots which increases risk of catheter block  May need to add 500units of heparin to 1 or 2 bags a day until fibrin clots decrease  Constipation is common – you may need to stop the calcium based phosphate binders temporarily but better off using aperients early and preventing the need to alter routine meds
  44. 44. Peritonitis  Fluid regimes  Depends whether patient is overloaded or underloaded  Can usually continue normal regime but tailor to patient  If BP low, use 1.5% bags x 4 a day  If BP high use 2.3% bags, minimum of 4 a day  Aim for BP 120/  APD pts can continue on APD or if needed can convert temporarily to CAPD – in Broome with resources this should not be necessary
  45. 45. Peritonitis  Can get changes in the permeability of the peritoneal membrane  Permeability to water, glucose and proteins is increased  Rapid glucose absorption from the dialysis solution reduces amount of ultrafiltration and can result in fluid overload  May need high glucose concentration dialysate with shorter dwells  Hyperglycaemia is common  Protein loss is increased in peritonitis so patients will need high protein supplements
  46. 46. Peritonitis  Don’t forget secondary causes of peritonitis  Perforated gastric or duodenal ulcer  Pancreatitis  Appendicitis  Diverticulitis  PID  Talk to the surgeon if you are not sure
  47. 47. Peritonitis  You don’t necessarily have to admit the patient  Admission dictated by symptoms and distress and often social circumstances up here cms.ich.ucl.ac.uk/website/imagebank/images blogs.southshorenow.ca/louise/
  48. 48. Peritonitis - bugs  Staph – Vancomycin and repeat in 1 week  Patients should have nasal carriage treated with mupirocin bd for 5 days and then once a week of bd for 5 days once a month  Gram Negs – IP Ceftriaxone for 2 weeks and consider repeating the dose of gentamicin after a week or adding oral ciprofloxacin to the regime  Pseudomonas difficult to treat  Sternotrophomonas – usually requires 2 antibiotics and usually for 4 weeks  Campylobacter not that common – responds to gentamicin
  49. 49. Peritonitis  Multiple organisms  Have a high index of suspicion for secondary peritonitis  If not secondary peritonitis have 60% chance of curing with appropriate antibiotics  If one of the organisms is clostridium or bacteroides – likely intra-abdominal abscess or perforated abdominal viscus but exclude appendicitis, perforated ulcer, pancreatitis and any other cause of secondary peritonitis  Occurrence of abdominal catastrophe in PD patient has a high mortality  Talk to the surgeon  Add metronidazole  Ship south
  50. 50. Peritonitis  Culture negative disease  If cell count less than 50 x 106…unlikely to peritonitis  If higher white cell count, then repeat empiric therapy  Make sure lab is doing cultures for AFB’s and fungus  If not improving consider legionella, campylobacter, ureaplama, mycoplasma, enteroviruses, fungus, histoplasma capsulatum
  51. 51. Peritonitis  Fungal peritonitis  Predisposing factors  Prior antibiotic use especially if not full treatment  Immunosuppressive therapy  HIV  Malnutrition  Low albumin  Diabetes
  52. 52. Peritonitis  Fungal peritonitis  We tend to try and save the tube by giving antifungals but guidelines recommend prompt removal of catheter, conversion to haemodialysis for a few weeks and then start from scratch  Penetration of antifungals to peritoneum other than with IP administration, is poor
  53. 53. Peritonitis  Refractory disease  Defined as disease that is treated with appropriate antibiotics for 5 days without improvement  Catheter removal necessary to reduce morbidity and preserve peritoneum  Increased with gram neg bugs
  54. 54. Peritonitis  Relapsing disease  Peritonitis with the same organism within 4 weeks of stopping therapy  Usually Staph epidermidis or a gram negative organism  If pseudomonas or gram negatives, remove the catheter  If staph, may be able to rescue with repeat vancomycin weekly for a month or may be able to remove the tube and simultaneously insert a new tube (as opposed to any other organism where a 2 month peritoneal rest is required)  Sometimes can use urokinase to strip the biofilm (bacteria entrapped in fibrin in the peritoneal membrane) in relapsing disease – last resort but worth a go
  55. 55. Peritonitis  20% of episodes temporally associated with exit site and tunnel infections (Piraino et al 2005)  Treat exit site infections if red and purulent  Swab it  Start Flucloxacillin empirically and change or add ciprofloxacin if gram neg  Exit sites are another whole topic
  56. 56. Peritonitis  Prevention  Good technique  Hygiene  Mupirocin  Exit site care  Anchor tape
  57. 57. Cochrane Review 2009  Implications for practice• At the present time broad spectrum antibiotics should be initiated at the time a diagnosis of peritonitis is made. When choosing antibiotics the side-effect profile, local drug resistance patterns and previous antibiotic use and infection history in the individual concerned should be considered. In cases of recurrent peritonitis dialysis catheters should be removed rather than using intraperitoneal urokinase. •  Currently available evidence from RCTs is inadequate in many areas of clinical practice important in the management of PD-associated peritonitis. This is a limiting factor in the provision of definitive treatment guidelines.
  58. 58. Cochrane Review 2009  Implications for research• Further studies are required to establish the most effective treatment for peritoneal dialysis- associated peritonitis. An essential feature of such studies is inclusion of enough patients to ensure adequate power to assess meaningful long and short term outcomes. Short term outcomes should extend beyond whether cure is achieved without catheter removal, for example duration of systemic inflammation. Study of long-term outcomes should include permanent transfer to haemodialysis, development of ultrafiltration failure patient death and late recurrent episodes of peritonitis beyond four weeks from the original episode. • Specific interventions that would be of value include early versus late catheter removal. Studies designed to study infections due to specific organisms would also be valuable. An example is a study of glycopeptide versus cephalosporin therapy in peritonitis due to coagulase negative Staphylococcal species. The majority of studies have included patients on CAPD rather than APD hence studies designed to test the efficacy of antibiotics in APD are required. This is particularly applicable to studies of intermittent versus continuous dosing when cycler dwell times may well influence pharmacokinetics. • Future research should be conducted using standard definitions, with inclusion of information about factors that may influence the response to therapy such as prophylaxis regimens and dialysis solutions used. Current ISPD guidelines provide a comprehensive list of requirements for future studies that should be referred to when designing studies.
  59. 59. Take home points •Have a high index of suspicion •Use the remote area manual •Always let KRSS know of episode •Copy all results to KRSS •Don’t hesitate to ask if you are not sure – KRSS team, KRSS GP, Renal GP, Nephrologist www.learningradiology.com
  60. 60. Acknowledgements  Thanks to Daugirdas et al 2007 – Handbook of dialysis  http://mrw.interscience.wiley.com/cochrane/ clsysrev/articles/CD005284/frame.html
  61. 61. Thank you  Questions  renalgp@kamsc.org.au

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