CURRICULUM VITAE PERSONAL DATA Name: Gregory Roland Dressler ...Document Transcript
Name: Gregory Roland Dressler
Address: BSRB 2049 1606 Cambridge Rd.
109 Zina Pitcher Dr. Ann Arbor, MI 48104
Ann Arbor, MI 48109-2200
1977-1981 University of Pennsylvania, Philadelphia, PA, B.S.E. in Bioengineering and
Chemical Engineering, cum laude.
1982-1986 University of Pennsylvania, Philadelphia, PA; Ph. D. in Genetics and
1987-1989 Postdoctoral Fellow, The Max Planck Institute for Biophysical Chemistry,
Goettingen, Germany, Laboratory of Prof. Peter Gruss.
1990 -1995 Senior Staff Fellow, Unit on Molecular Embryology, Laboratory of
Mammalian Genes and Development, NICHD, Bethesda, MD.
1995-1998 Assistant Investigator, Howard Hughes Medical Institute
1995 Assistant Professor, Dept. of Pathology, University of Michigan
2000 Associate Professor, Dept. of Pathology, University of Michigan
1993 Ad-Hoc Member for Kidney Center Review Study Section, NIDDK
1994 Ad-Hoc Member for Biological Sciences study section for NRSA
1994 Meeting Organizer, ”Antisense Technologies: their uses in development”
March 8-9, NICHD, Bethesda, MD
1995 Abstract Reviewer, ASN Annual Meeting
1997 Ad-hoc Member, General Medicine B Study Section, NIH
1997 Abstract Reviewer, ASN Annual Meeting
1998 General Medicine B Study Section, special session
Editorial Reviews Board, American Journal of Physiology
NIDDK, Renal Program Project Grants, Site visit reviewer
Guest Editor, Developmental Genetics, Renal Development Issue
Polycystic Kidney Research Foundation, Grant Review Study Section
1999 NIDDK Study Group, “Prostate Gene Expression Technology”
Reviewer, ASN Annual Meeting
NIH, Center for Scientific Review, ZRG1 SSS-1, reviewer
2000 NIH General Medicine B Study Section Member
NIH Study Section, ZHD1 RRG-K (08) reviewer
2001 Human Frontiers in Sciences Program, reviewer
NIH General Medicine B Study Section Member
Irish National Research Council, reviewer
2002 NIH General Medicine B Study Section Member
Welcome Trust Reviewer
2003 Editorial Board Member, Developmental Dynamics
NCI Site Visit, Columbia University School of Medicine
NIDDK initiative for the Kidney Gene Expression Atlas
The Faculty of 1000, member
2004 NIH Urological Disease and Kidney Development Study Section member
NIDDK Special Emphasis Panel ZDK1 GRB-7
2005 NIDDK Special Emphasis Panel P30 PKD
NIDDK, MAGUD Advisory Board
American Society of Nephrology, Basic Science Committee
2006 PBMK Study Section, Ad-hoc
2007 Editorial Board Member, J. Amer. Society Nephrology
Co-organizer, Kidney Development and Repair, NIDDK Conference
UKGD Study Section Ad-hoc member
Reviewer for: Mechanisms of Development, Development, Cell, Proceedings of the National
Academy of Sciences, Developmental Dynamics, J. of Biological Chemistry, Nature, American J.
of Physiology, J. of Clinical Investigation, Molecular and Cellular Biology, Genes & Development,
Kidney International, J. of Cell Biology, Cell, Am. J. Pathology, Cancer Research, Nature Genetics,
J. of Cell Science, J. American Society of Nephrology
1982-86 National Institute of Health Training Grant CA09171 to the Wistar
1987-89 Alexander von Humboldt Fellowship
1995-98 Support for salary, personnel, and laboratory supplies provided by the
Howard Hughes Medical Institute, Chevy Chase, MD.
1996-98 Mentor, Welcome Trust postdoctoral fellowship for J. Martin
1995-00 Principal Investigator, R01 DK51043, Pax-2 in Normal and Cystic
Development, $84,596 current year; $440,573 total direct costs
1998-02 Co-Investigator, P50 DK39255 (R. Wiggins, P.I.), Project 3, “Functional
analysis of RET signaling in renal epithelial cells”, approximately
$80,000/year direct costs.
1999-03 Principal Investigator, R01 DK54723, Cell Migration, Chemoattraction and
the RET/GDNF Pathway, approximately $144,000/year direct costs
2003-05 Mentor, Polycystic Kidney Disease Foundation fellowship to Dr. Yi Cai,
40,000/year direct costs.
2003-05 Polycystic Kidney Research Foundation, $50,000 Grant-in-Aid
2003-05 Mentor, American Foundation for Urological Disease Fellowship to Dr.
Doyeob Kim, 40,000/year direct costs.
1999-07 Principal Investigator, R01 DK54740, Pax2 Interacting Proteins in
Development and Disease, approximately $175,000/year direct costs
2000-05 Mentor, K08 DK02803 to Dr. Sanjeevkumar Patel, 128,000/year direct costs.
2003-07 Principal Investigator, R01 DK062914, Cell Signaling in Developing
Epithelia, $175,000/year direct costs
2005-07 Principal Investigator, R21 069689, Differentiation of ES cells into renal
epithelia, $90,000/direct costs
2006-11 Principal Investigator, R01 DK073722, Epigenetic Regulation of Kidney
Development, $205,000/ year direct costs.
HONORS AND AWARDS
1981 Graduated cum laude
1987 Received the Alexander von Humbold Fellowship
MEMBERSHIPS AND OFFICES IN PROFESSIONAL SOCIETIES
American Society of Nephrology
Society for Developmental Biology
1995-1997 Lecturer, Anatomy & Cell Biology 580
1995- Lecturer, Biology 421
1996-1997 Lecturer, Biology 405
1997- Organized and Lectured the Center for Organogenesis Short Course
“Organogenesis of a Complex Tissue”
1997-2003 Lecturer, Renal Section, 2nd Year Medical Students
1999 Anatomy and Cell Biology 530, 3h
2000-06 Pathology 581, Dev. Pathology Section, 3h
2000 Cell and Developmental Biology 580, 3h
2000-06 Pathology 582, course director
2000-04 Cell & Developmental Biology 530, 3h
2001 Cell & Developmental Biology 680, 12h
2002 Biology 201, 1h
2004-06 M1 Renal Embryology 2h, Sex Determination 1h
Postdoctoral Fellows Subsequent Position
Uwe W. Rothenpieler, M.D. (1990-1993) Medizinische Poliklinik, University of Munich,
Gabriella Ryan, Ph.D. (1993-1994) Senior Staff Fellow, NIGR, Bethesda, MD
Larry Patterson, M.D. (1992-1994) Bowman Gray School of Medicine, Winston-
Mark S. Lechner, Ph.D. (1995-98) The Wistar Institute, Philadelphia, PA
Eun-Ah Cho, Ph.D. (1995-2000) NIH, Bethesda, MD.
Julie S. Martin, Ph.D. (1996-98) University College London
Yi Cai, M.D., Ph.D. (1998-2006) Pediatric Resident, NY
Patrick Brophy, M.D. (1999-2002) Dept. of Pediatrics, Univ. of Michigan
Sanj Patel, M.D. (1999-2004) Dept. of Medicine, Univ. of Michigan
Doyoeb Kim, Ph.D. (2002-
Hong Xiao, M.D., Ph.D. (2006- )
Kristopher Schwab, Ph.D. (2006- )
Dawn E. Phelps (1992-1994) Dept. of Genetics, The George Washington University,
Jing-Mei Lin (2000-04) Dept. of Pathology, University of Michigan
Marc Prindle (2001- ) Cell and Molecular Biology, University of Michigan
Laura Post, Dept. of Human Genetics, Univ. of Michigan (1996-1999)
Pei-Jiun Chen, Dept. of Biology (1997-2000)
Kristen Coulter, Dept. of Human Genetics, Univ. of Michigan (1997-2002)
Hoonkyu Suh, Dept. of Human Genetics (1998-2002)
Tom Hliang, Dept. of Pathology (2000-2002)
Yue Ge, Cell and Molecular Biology (2000-2002)
Brian Gummow, Physiology (2001-05)
Ira Weiner, MSTP (2002-05)
Brian MacDonald, Human genetics (2001- 04)
Robert Ward, Cell and Molecular Biology (2002- 05)
Collen Doyle, Human Genetics (2003-05)
Jennifer Linn, Cell and Developmental Biology (2006-)
Sara Monroe, Pathology (2006-)
EXTRAMURAL INVITED PRESENTATIONS
1992 The Archibald MacCallum Lecture, Dept. of Biochem., McGill University, Montreal.
Airlie House meeting, sponsored by NICHD, Airlie, VA.
1993 Wistar Institute, Philadelphia, PA.
Dept. of Genetics, The George Washington University, Washington, DC
Dept. of Pathology, University of Michigan, Ann Arbor, MI
1994 Basic Science Symposium, National Kidney Foundation annual meeting, Orlando,
Biogen Corporation, Cambridge, MA.
Molecular Genetics of Tumor Progression and Metastisis, meeting sponsored by the
American Association for Cancer Research, Big Sky, MT.
Airlie House Meeting, sponsored by NICHD, Airlie, VA.
Brookdale Center for Molecular Biology, Mt. Sinai University Medical School, NY.
36th annual Southeast Regional Developmental Biology Conference, Duke
University, Durham, NC.
1995 HHMI Annual Meeting, Chevy Chase, MD.
Midwest Society for Pediatric Research, Annual Meeting, Chicago, IL .
Seventh International Symposium on Basement Membranes, Bethesda, MD.
The Sixth International Workshop on Developmental Nephrology, Airlie, VA.
2nd International Conference on Molecular and Clinical Genetics of Childhood
Renal Tumors, Philadelphia, PA.
Dept. of Nephrology, Columbia University, New York, NY.
1996 Neckers Seminars in Nephrology, The Neckers Hospital, Paris, France.
Hybridon Inc., Worchester, MA.
Renal Developmental Biology, ASN Basic Science Symposium, New Orleans, LA.
Mini Lecture, ASN Annual meeting, New Orleans, LA.
The Max Planck Institute for Developmental Biology, Tuebingen, Germany.
HHMI Annual Meeting, Chevy Chase, MD.
1997 Dept. of Cancer Biology, The Cleveland Clinic, Cleveland, OH.
Penn Center for Molecular Studies of kidney Diseases, University of Pennsylvania,
Dept. of Cell Biology, Duke University, Durham, NC.
International Society of Developmental Biology, annual meeting, Snowbird, UT,
(speaker & session chair).
NIDDK Workshop on Polycystic Kidney Disease, Crystal City, VA.
HHMI Annual Meeting, Chevy Chase, MD
1998 Experimental Biology 98, San Fransisco, CA.
Division of Biological Sciences, University of Edinburgh, Edinburgh, UK.
Dept. of Biochemistry, University of Virginia Medical center, Charlottesville, VA.
Experimental Genetics of the Laboratory Mouse, Jackson Labs, Bar Harbor, ME.
HHMI Annual Meeting, Chevy Chase, MD.
23rd Annual Argenteuil Symposium, Princess Lillian Foundation ,”Kidney
Development has Clinical Impact”, Brussels, Belgium.
1999 Dept. of Biochemistry, LSU Medical Center, New Orleans, LA
Dept. of Anatomy, University of Kansas Medical School, Kansas City, KS
Dept. of Biochemistry, Medical College of South Carolina, Charleston, SC
2000 Division of Developmental Biology, Childrens Hospital, Univ. of Cincinnati, OH
2001 Dept. of Molecular Genetics, Baylor College of Medicine, Houston, TX
Depts. of Pediatrics and Cell and Molecular Biology, Tulane Univ., New Orleans,
8th International Workshop on Developmental Nephrology, Victoria, BC
American Society of Nephrology, Annual Meeting, San Fransisco, CA
German Society for Nephrology, Annual Meeting, Muenster, Germany
Banbury Conference on Epithelial & Endothelial Tube Morphogenesis, Cold Spring
2002 Dept. of Cell Biology, Univ. of Alabama, Birmingham, AL
European Nephrogenesis Workshop IX, Royal College of Physicians, Dublin, Ireland
Dept. of Anatomy, Indiana University School of Medicine, Indianapolis, IN.
Max Planck Institute for Biophysical Chemistry, Goettingen, Germany
Dept. of Medicine, Vanderbilt University, Nashville, TN.
2003 Dept. of Pathology, Boston University School of Medicine
Dept. of Genetics, St. Jude’s Children’s Research Hospital, Memphis, TN
American Society of Nephrology Annual Meeting, San Diego
2004 Keystone Meeting on Cell Signaling in Development, Santa Fe, NM.
Dept. of Genetics, Cell Biology, and Anatomy, Univ. of Nebraska, Omaha
Third Course on Genetics and Renal Disease, Genoa, Italy
2005 Dept. of Biochemistry & Biophysics, Oregon State Univ., Corvallis
Dept. of Biology, Purdue University Indianapolis, IN.
Division of Nephrology, Brigham and Women’s Hospital, Boston, MA.
Plenary lecture, American Society of Nephrology Annual Meeting, Philadelphia, PA
2006 ICOS Corporation, Bothel, WA.
Maine Medical Center Research Institute, Portland, ME
Dep. of Pediatrics, Hospital for Sick Children, Toronto, Canada
Ottawa Health Research Institute, Ottawa, Canada
Plenary lecture, American Society of Nephrology Annual Meeting, San Diego, CA
International Nephrology Conference, Ann Arbor, MI
Columbus Children’s Research Institute, Columbus, OH
Dept. of Pathology, Northwestern University, Chicago, Il
2007 Dept. of Biology, Univ. of Kentucky, Lexington
Kidney Development and Repair, NIDDK Conference, Alexandria, VA
Forefront Symposium on Nephrogenetics, Danvers , MA
Dept. of Medicine, Vanderbilt University, Nashville, TN
California National Primate Center, UC Davis, CA
International Symposia on Kidney Development and Tissue Engineering, Oulu,
International Developmental Nephrology Workshop, Pecs, Hungary
Dept. of Medicine, University of Cincinnati, OH
Plenary lecture, American Society of Nephrology Annual Meeting, San Fransisco,
COMMITTEE AND ADMINISTRATIVE SERVICE
1996-2005 Organogenesis Symposium Organizing Committee
Reviewer for Organogenesis Training Grant Applications
1997-2007 Interim Co-director, Center for Organogenesis
1998-2007 Graduate Program in Cell and Molecular Biology
1998-2004 Pathology Graduate Program Preliminary Exam Committee
1998-2004 Graduate Program in Biomedical Sciences Admissions Committee
2006- American Society of Nephrology, Basic Science Committee
1. Dressler, G.R. and Fraser, N.W. (1987). DNA Sequences Downstream of the Adenovirus Type
2 Fiber Polyadenylation Site Contain Transcription Termination Signals. J. Virol. 61, 2770-
2. Dressler, G.R., Rock, D.L., Fraser, N.W.(1987). Latent Herpes Simplex Virus Type 1 DNA is
not Extensively Methylated in vivo. J. Gen. Virol. 68, 1761-1765.
3. Chowdhury, K., Dressler, G.R., Breier, G., Deutsch, U., Gruss, P. (1988) The primary structure
of the murine mKr2 gene and its specific expression in adult and developing neurons.
EMBO J. 7, 1345-1353.
4. Breier, G., Dressler, G.R., Gruss, P. (1988) Primary structure and developmental expression
pattern of Hox 3.1, a member of the murine Hox 3 homeobox gene cluster. EMBO J. 7, 1329-
5. Deutsch, U., Dressler, G.R., Gruss, P. (1988) Pax 1, a member of a paired box homologous
murine gene family, is expressed in segmented structures during development. Cell 53, 617-
6. Dressler, G.R. and Gruss, P. (1988) Do multi-gene families regulate vertebrate development?
Trends in Genetics 4, 214-219
7. Dressler, G.R., Deutsch, U., Balling, R., Simon, D., Guenet, J-L., Gruss, P. (1988) Murine genes
with homology to Drosophila segmentation genes. Development 104 supplement, 181-186.
8. Duprey, P., Chowdhury, K., Dressler, G.R., Balling, R., Simon, D., Guenet, J.-L., Gruss, P.
(1988) A mouse gene homologous to the Drosophila gene caudal is expressed in epithelial cells
from the embryonic intestine. Genes & Develop. 2, 1647-1654.
9. Dressler, G. R. and Fraser, N. W. (1989) The Adenovirus-2 major late transcription termination
region contains multiple functional elements. J. Gen. Virol. 70, 1337-1345.
10. Dressler, G. R. (1989) An update on the vertebrate homeobox. Trends in Genetics 5, 129-131.
11. Dressler, G. R. and Gruss, P. (1989) Anterior boundries of Hox gene expression in mesoderm
derived structures correlate with the linear gene order along the chromosome. Differentiation
12. Püschel, A. W., Balling, R., Dressler, G. R., Gruss, P. (1989) The Hox 1.1 promoter directs
expression to a specific region of the embryo in transgenic mice. in Current Communications in
Molecular Biology: Molecular Genetics of Early Drosophila and Mouse Development. (M. R.
13. Dressler, G.R., Deutsch, U., Chowdhury, K., Nornes, H., Gruss, P. (1990) Pax2 a new murine
paired box containing gene and its expression in the developing excretory system. Development
14. Nornes, H., Dressler, G. R., Knapik, E. W., Deutsch, U., Gruss, P. (1990) Spatially and
temporally restricted expression of Pax2 during murine neurogenesis. Development 109, 797-
15. Schoeller, H., Dressler, G. R., Balling, R., Rohdewold, H., Gruss, P. (1990) Oct4, a germ line
specific transcription factor mapping to the mouse t-complex. EMBO J. 9, 2185-2195.
16. Dressler, G. R. and Douglass, E. C. (1992) Pax-2 is a DNA binding protein expressed in
embryonic kidney and Wilms' tumor. Proc. Natl. Acad. Sci. USA 89, 1179-1183.
17. Pueschel, A. W., Westerfield, M., Dressler, G. R. (1992) Comparative analysis of Pax-2 protein
distributions during neurulation in mice and zebrafish. Mech. Develop. 38, 197-208.
18. Rothenpieler, U. W. and Dressler, G. R. (1993) Pax-2 is required for mesenchyme to epithelium
conversion during kidney development. Development 119, 711-720.
19. Phelps, D. E., Dressler, G. R. (1993) Aberrant expression of Pax-2 in Danforth's short tail (Sd)
mice. Develop. Biol. 157, 251-258.
20. Rothenpieler, U.W. and Dressler, G. R. (1993) Differential Distribution of
Oligodeoxynucleotides in Developing Organs with Epithelial and Mesenchymal Interactions.
Nucleic Acids Res. 21, 4961-4966.
21. Dressler, G. R., Wilkinson, J. E., Rothenpieler, U. W., Patterson, L. T., Williams, L., Westphal,
H. (1993) Deregulation of Pax-2 expression in transgenic mice generates severe kidney
abnormalitites. Nature 362, 65-67.
22. Dressler, G.R. (1994) The pros and cons of c-ret. Current Biol. 4, 354-356.
23. Patterson, L.T. and Dressler, G. R. (1994) Regulation of Kidney Development: new insights
from an old model. Curr. Opin. Genet. Develop. 4, 696-702.
24. Dressler, G. R. (1995) Developmental Control Genes, in Molecular Nephrology (D.
Schloendorff and J. Bonventre eds.) Marcel Dekker, New York, pp1-13.
25. Ryan, G., Steele-Perkins, V., Morris, J., Rauscher, F. J. III, Dressler, G.R. (1995) Repression
ofPax-2 byWT1 during normal kidney development. Development 121, 867-875.
26. Dressler, G. R. (1995) Transcription factors in renal development: the WT1 and Pax-2 story.
Sem. Nephrol. 15, 263-271.
27. Dressler, G. R. (1995) The genetic control of renal development. Curr. Opin. Hyper. Nephrol.
28. Gnarra, J. R. and Dressler, G. R. (1995) Expression of Pax-2 in renal cell carcinoma and growth
inhibition by antisense oligonucleotides. Cancer Research.55, 4092-4098.
29. Torres, M., Gomez-Pardo, E., Dressler, G. R. and Gruss, P. (1995) Pax-2 controls multiple steps
in urogenital development. Development 121, 4057-4065.
30. Phelps, D.E. and Dressler, G. R. (1996) Identification of NovelPax-2 binding sequences by
chromatin immunoprecipitation. J. Biol. Chem. 271, 7978-7985.
31. Dressler, G. R. (1996) Pax-2, kidney development and oncogenesis. Med. Ped. Oncol. 27, 440-
32. Winyard, P.J.D., Risdon, A.R., Sams, V.R., Dressler, G.R. and Woolf, A.S. (1996) The Pax2
transcription factor is overexpressed in cystic and hyperproliferative dysplastic epithelia in
human kidney malformations. J. Clin. Invest. 98, 451-459.
33. Lechner, M. S. and Dressler, G. R. (1996) Mapping of Pax-2 transcription activation domains.
J.Biol. Chem. 271, 21088-21093.
34. Dehbi, M., Gharemani, M., Lechner, M., Dressler, G. and Pelletier, J. (1996) The paired-box
transcription factor, PAX2, positively modulates expression of the Wilms’ tumor suppressor
gene (WT1). Oncogene 13, 447-453.
35. Vega, Q.C., Worby, C.D., Lechner, M.S., Dixon, J.E. and Dressler, G.R. (1996) Glial derived
neurotrophic factor is a ligand for RET and promotes kidney morphogenesis. Proc. Natl. Acad.
Sci. USA.93, 10657-10661
36. Dressler, G. R. (1997) Genetic control of kidney development. Adv. Nephrol. 26, 1-17.
37. Valentini, R., Brookhiser, W. T., Park, J., Yang, T., Briggs, J., Dressler, G.R., and Holzman,
L.B. (1997) Post-translational processing and renal expression of mouse indian hedgehog
cDNA. J. Biol. Chem. 272, 8466-8473.
38. Lechner, M. S. and Dressler, G. R (1997) The molecular basis of embryonic kidney
development. Mech. Develop. 62, 105-120.
39. Leavey, S.F., Arend, L.J., Dare, H., Dressler, G.R., Briggs, J.P. and Margolis, B.L. (1998)
Expression of Grb7 growth factor receptor signaling protein in kidney development and in the
adult kidney. Am. J. Physiol. 275, F770-F776.
40. Cho, E. A., Patterson, L.P., Brookhiser, W.T., Mah, S., Kintner, C. and Dressler, G.R. (1998)
Expression and function of cadherin-6 in the developing kidney. Development 125, 803-812.
41. Cho, E.A. and Dressler, G.R. (1998) Mouse Tcf-4 binds b-catenin and is expressed in distinct
regions of the developing brain and limbs. Mech. Develop. 77, 9-18.
42. Tang, M.J., Worley, D., Sanicola, M. and Dressler, G.R. (1998) The RET-Glial Cell-derived
Neurotrophic Factor (GDNF) pathway stimulates migration and chemoattraction of epithelial
cells. J. Cell Biol. 142, 1337-1345.
43. Weiss, J.B., Von Ohlen, T., Mellerick, D.M., Dressler, G., Doe, C.Q. and Scott, M.P. (1998).
Dorsoventral patterning in the Drosophila central nervous system: the intermediate neuroblasts
defective homeobox gene specifies intermediate column identity. Genes & Dev. 12, 3591-3602.
44. Yang, Y., Jeanpierre, C., Dressler, G.R., Lacoste, M., Niaudet, P. and Gubler, M.-C. (1999)
WT1 and Pax-2 podocyte expression in Denys-Drash syndrome and isolated diffuse mesangial
scelrosis. Am J. Pathol 154, 181-192.
45. Dressler, G.R. (1999) Kidney development branches out. Dev. Genetics 24, 189-193.
46. Schwarz, M., Alvarez-Bolado, G., Dressler, G., Urbanek, P., Busslinger, M., and Gruss, P.
(1999) Pax2/5 and Pax6 subdivide the early neural tube into three domains. Mech. Dev. 82, 29-
47. Dressler, G. R. and Woolf, A. S. (1999) Pax2 in development and renal disease. Int. J. Dev.
Biol. 43, 463-468.
48. Ostrom, L., Tang, M.-J., Gruss, P., and Dressler, G.R. (2000) Reduced Pax2 gene dosage
increases apoptosis and slows the progression of renal cystic disease. Dev. Biol. 219, 250–258
49. Mah, S.P., Saueressig, H., Goulding, M., Kintner, C., and Dressler, G.R. (2000) Kidney
development in cadherin-6 mutants: delayed mesenchymal-to-epithelial conversion and loss of
nephrons. Dev. Biol. 223, 38-53.
50. Lechner, M.S. Levitan, I. and Dressler, G.R. (2000) PTIP, A novel BRCT-domain protein
interacts with Pax2 and is associated with active chromatin. Nucleic Acids Res. 28, 2741-2751.
51. Dressler, G.R. (2001) The Development of the Excretory System. In: Mouse Development (J.
Rossant and P. Tam, eds.) Academic Press, NY, pp395-420.
52. Brophy, P.D, Ostrom, L., Lang, K.M. and Dressler, G.R. (2001) Regulation of Ureteric Bud
Outgrowth by Pax2 Dependent Activation of the Glial Derived Neurotrophic Factor Gene.
Development 128, 4747-4756.
53. Cai, Y., Lechner, M.S., Nihalani, D., Prindle, M., Holzman, L.B. and Dressler, G.R. (2002)
Phosphorylation of Pax2 by the c-Jun N-terminal kinase and enhanced Pax2 dependent
transactivation. J. Biol Chem. 277, 1217-1222.
54. Tang, M.J., Cai, Y., Tsai, S.J., Wang, Y.K. and Dressler, G.R. (2002) Ureteric Bud Outgrowth
in Response to RET Activation is Mediated by Phosphatidylinositol-3 Kinase. Dev. Biol. 243,
55. Silberstein, G. B, Dressler, G.R. and Van Horn, K. (2002) Expression of the Pax2 oncogene in
human breast cancer and its role in progesterone dependent mammary growth. Oncogene 21,
56. Hoffmeister, A., Ropolo, A.,Vasseur, S., Mallo, G.V., Bodeker, H., Ritz-Laser, B., Dressler,
G.R., Vaccaro, M.I., Dagorn, J.C., Moreno, S. and Iovanna, J.L. (2002) The HMG-I/Y-related
protein p8 binds to p300 and Pax2 trans-activation-domain interacting protein to regulate the
trans-activation activity of the Pax2A and Pax2B transcription factors on the glucagon gene
promoter. J. Biol. Chem. 277, 22314-22319.
57. Dressler, G.R. (2002) Tubulogenesis in the developing mammalian kidney. Trends Cell Biol.
58. Cho, E.A. and Dressler, G.R. (2003) The Formation and Development of Nephrons. In: The
kidney: Normal Development to Congenital Abnormalities (P. D. Vize, A. S. Woolf, J. B. L.
Bard, eds) Academic Press, pp195-210.
59. Cho, E.A., Prindle, M.J. and Dressler, G.R. (2003) The BRCT domain protein PTIP is required
for progression through mitosis. Mol. Cell. Biol. 23, 1666-1673
60. Cai, Y., Brophy, P., Levitan, I. and Stefano, S. and Dressler, G.R. (2003) Groucho suppresses
Pax2 transactivation by inhibition of JNK mediated phosphorylation. EMBO J.22, 5522-5529
61. Brophy, P.D., Lang, K.M., and Dressler, G.R. (2003) The secreted frizzled related protein
SFRP2 is a target of the Pax2 transcription factor. J. Biol. Chem. 278, 52401-52405.
62. Patel, S. R. and Dressler, G.R. (2004) Expression of Pax2 in the intermediate mesoderm is
regulated by YY1. Dev. Biol. 267, 505-516.
63. Dressler, G. R. (2004) Cell Lineages and Stem cells in the Embryonic Kidney. In: Handbook of
Stem Cells, Vol.1: Embryonic Stem Cells (R. Lanza, ed.) Elsevier Science, San Diego, CA,
64. Lin, J., Patel, S.R., Cheng, X., Cho, E. A., Levitan, I., Ullenbruch, M., Phan, S.H., Park, J.M.
and Dressler, G.R. (2005) Kielin/Chordin-like protein (KCP), a novel enhancer of BMP
signaling attenuates renal fibrotic disease. Nature Medicine, 11, 387-393 (featured in news and
65. Kim, D. and Dressler, G.R. (2005) Nephrogenic factors promote differentiation of mouse
embryonic stem cells into renal epithelia. J. Am. Soc. Nephrol. 16, 3527-3534.
66. Patel, S. R. and Dressler, G. R. (2005) BMP signaling in development and disease. Trends in
Mol. Med. 11, 512-518.
67. Dressler, G. R. (2006) Cell lineages and stem cells in the embryonic kidney. In: Essentials of
Stem Cell Biology (R. Lanza, ed.) Elsevier Science, San Diego, CA, p227-236.
68. Lin, J., Patel, S. R., Wang, M. and Dressler, G.R. (2006) The cysteine rich domain protein KCP
suppresses TGF- /Activin signaling in renal epithelia. Mol. Cell. Biol. 26, 4577-4585.
69. Dressler, G. R. (2006) The cellular basis of kidney development. Ann. Rev. Cell Dev. Biol. 22,
70. Self, M., Lagutin, O., Bowling, B., Hendrix, J., Cai, Y., Dressler, G. R. and Oliver, G. (2006)
The Six2 gene is required for suppression of inductive signals and progenitor cell renewal in the
developing kidney. EMBO J, 25, 5214-5228.
71. Clarke, J. C., Patel, S. R., Raymond, R. M., Andrew, S., Robinson, B. G., Dressler, G. R. and
Brophy, P. D. (2006) Pax2 regulates the expression of c-Ret during branching morphogenesis in
the mammalian kidney. Hum. Mol. Genetics, 15, 3420-3428.
72. Dressler, G.R. (2007) Stem cells in kidney development and regeneration. Prog. Tissue Eng., in
73. Kim, D, Wang, M., Cai, Q., Brooks, H. and Dressler, G.R. (2007) The Pax2 Interacting Protein
PTIP is Required for Urine Concentration and Osmotolerance in Collecting Duct Epithelia. J.
Am. Soc. Nephrol. 18, 1458-1465.
74. Kim, D. and Dressler, G. R. (2007) PTEN modulates GDNF/RET mediated chemotaxis and
branching morphogenesis in the developing kidney. Dev. Biol.,307, 209-299.
75. Cho, Y.W., Hong, T., Hong, S.H., Yu, H., Kim, D., Guszczynski, T., Dressler, G.R., Copeland,
T., Kalkum, M. and Ge, K. (2007) PTIP associates with MLL3 and MLL4 containing histone
H3 lysine 4 methyltransferase complex. J. Biol Chem. 282, 20395-20406.
76. Gong, K.Q., Yallowitz, A.R., Sun, H., Dressler, G.R. and Wellik, D.M. (2007) Physical
association of a Hox-Eya-Pax complex at enhancer sequences regulates expression of early
patterning genes in the developing kidney. Mol. Cell Biol. in press.
77. Viana, R., Batourina, E., Hunag, H., Dressler, G.R., Behringer, R.R., Kobayashi, A., Shapiro,
E., Hensle, T. and Mendelsohn, C. (2007) The development of the bladder trigone, the center of
the anti-reflux mechanism. Development, in press
78. Patel, S.R., Kim, D., Levitan, I. and Dressler, G.R. (2007) The BRCT-domain containing protein
PTIP interacts with a histone H3 lysine 4 methyltransferase complex to regulate development.
79. Feng, M and Dressler, G.R. (2007) Drosophila PTIP interacts with the Polycomb/Trithorax
pathways and is essential for development. submitted.
80. Kim, D. and Dressler, G.R. (2007) An essential role for PTIP in maintaining embryonic stem
cell pluripotency. submitted.
81. Prindle, M., Patel, S.R., and Dressler, G.R. (2007) Characterization of cell growth and the DNA
damage response in PTIP mutant fibroblasts. submitted.