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Please collect the PPT on Determination of Antibody titres in adult stray/free roaming & domestic canines against antirabies immunization by by RFFIT

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  1. 1. Determination of antibody titres in adult stray/free roaming and domestic canines against anti-rabies immunization by RFFIT A Preliminary report Pimburage R M S 1 , Gunatilake M 2 , Wimalaratne O 3 , Balasuriya A 4 , Perera K A D N 3 1 Deprtment of Public Health Veterinary Services, Ministry of Health 2 Department of Physiology, Faculty of Medicine, Colombo 08 3 Department of Rabies Research and Vaccine Quality control, Medical Research Institute, Colombo 08 4 Faculty of Medicine, General Sir John Kotelawala Defence University
  2. 2. <ul><li>. Rabies a significant health problem in Sri Lanka </li></ul><ul><li>Involves large investment </li></ul><ul><li>The main reservoir and transmitter in Sri Lanka is the dog </li></ul><ul><ul><li>Introduction </li></ul></ul>
  3. 3. <ul><li>Introduction cont. </li></ul><ul><ul><ul><li>Dog Population in Sri Lanka </li></ul></ul></ul><ul><ul><ul><li>Stray 64-75% </li></ul></ul></ul><ul><ul><ul><li>Domestic 25-36% </li></ul></ul></ul>Recommended Anti Rabies vaccine schedule : Age 6 weeks 3 months Annual Vaccination 1 st dose 1 st booster Annual booster
  4. 4. <ul><li>To determine rabies neutralizing antibody titers in </li></ul><ul><ul><li>unimmunized, adult stray / free roaming dogs </li></ul></ul><ul><ul><li>adult domestic dogs with an annual immunization history </li></ul></ul>Objective
  5. 5. Dogs were recruited from Kalutara district Method
  6. 6. <ul><li>Study population </li></ul>Domestic (n=34) Stray/free roaming(n=29) Representative Sample First Day 30th Day 180th Day 360th Day Collection of blood (D0) Injected ARV Collection of blood (D30) Collection of blood (D180) Collection of blood (D360) Analyzed by RFFIT
  7. 7. Comparison of AB titers Results
  8. 8. Results * Significantly higher (<0.05) than stray population Percentage of Canines with AB titres above 0.5 IU/ml (WHO Recommendation) Group Day 0 Day 30 Day 180 Day 360 Stray/ Free roaming (n=29) 10.3 % 68.9% 89.6% 62.1% Domestic (n=34) 76.5 %* 91.2% 85.3% 82.4%
  9. 9. <ul><li>Conclusions </li></ul><ul><li>Annual revaccination is likely to maintain protective antibody </li></ul><ul><li>titres in domestic dogs </li></ul><ul><li>Immunization of stray / free roaming dogs with a single </li></ul><ul><li>vaccine is not sufficient </li></ul>
  10. 10. Acknowledgment <ul><li>National Science Foundation of Sri Lanka for financial support. </li></ul><ul><li>Dog restrainers, other staff of Public Health Veterinary Services and Medical research Institute for their kind co-operation. </li></ul>
  11. 11. <ul><li>References </li></ul><ul><li>Records of Medical suppliers Division, Ministry of Health. </li></ul><ul><li>Records of Public Health Veterinary Services, Ministry of Health </li></ul><ul><li>M. Gunatilake, O Wimalarathne and K.A.D.N Perera. Determination of </li></ul><ul><li>efficacy and virus neutralizing antibody levels in canines before and after </li></ul><ul><li>immunization with anti rabies vaccine. </li></ul><ul><li>WHO Expert consultation on rabies. First report. Geneva, World Health </li></ul><ul><li>Organization, 2004 WHO Technical Report Series 931. </li></ul><ul><li>Prevention and Control of Rabies in the South-East Asia Region. World </li></ul><ul><li>Health Organization, Regional Office for South –East Asia. New Delhi (July </li></ul><ul><li>2004 ). </li></ul>
  12. 12. Thank You

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