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  • 1. 3-D BIOPRINTERS YESTERDAYS FICTION….. TODAY’S REALITY….. REHAN FAZAL
  • 2. CONTENTS..  INTRODUCTION TO 3D PRINTERS  WORKING OF 3D PRINTERS  BIO PRINTERS  APPLICATIONS  NEED OF BIOPRINTERS  FUTURE PROJECTS  LOOPHOLES  CONCLUSION
  • 3. 3-D PRINTER..TRUE ??  Additive manufacturing or 3D printing is a process of making a three-dimensional solid object of virtually any shape from a digital model.  3D printing is achieved using an additive process, where successive layers of material are laid down in different shapes.  The first working 3D printer was created in 1984 by Chuck Hull of 3D Systems Corp.
  • 4. HOW IT WORKS..???
  • 5. Part I: The Frame Part II: The Y-Axis Part III: The X-Axis Part IV: The Z-Axis Part V: The Extruder Part VI: The Build Platform Part VII: The Electronics
  • 6. MATERIAL USED..
  • 7. SOFTWARE USED…
  • 8. Bioprinter  Yesterday’s Science Fiction is Becoming Today’s Reality in the Medical Field / Image still of characters using supposed “Dermal Regenerator” to heal a cut from an episode of popular Science Fiction series “Star Trek” Photo of Organovo scientist working with the company’s “NovoGen” bioprinter
  • 9. -Uses common inkjet printer technology to spray new skin tissue onto burn wounds instead of grafting skin -Patient’s own healthy cells used to create new skin -Computer uses scanner to create 3D map of wound -Printer sprays skin cells directly onto patient’s wound -Printer could soon be specially modified to be mounted above patient’s bed for use in hospitals Skin Bioprinter Plans for a human sized skin printer Photo of current skin bioprinter model http://inhabitat.com/skin-cell-spraying-bio-printer-can-heal-burn-victims-in-three-weeks/ http://singularityhub.com/2010/11/04/wake-forest-could-print-you-some-new-skin/
  • 10. Application -A camera uses a laser to scan the wound, creating a 3D model -Skin is made up of different layers which contain various types of skin cells -The computer tells the printer which cells to print where for precise application Plans for a human sized skin printer Digital 3D model of wound Example of laser scanning process http://inhabitat.com/skin-cell-spraying-bio-printer-can-heal-burn-victims-in-three-weeks/ http://singularityhub.com/2010/11/04/wake-forest-could-print-you-some-new-skin/ http://www.psfk.com/2010/08/future-of-health-bio-medical-printing.html
  • 11. How It Works -Tissue is printed in alternating layers of biopaper and bioink -Gelatin-like biopaper is biodegradable and mimics a normal cell environment to support the bioink -Bioink droplets are made up of the actual cells, which are printed in specific patterns to create the intended structure -Over time the biopaper dissolves and the individual bioink droplets fuse together to create new tissue Digital rendering of bioprinting process at cellular level with biopaper and bioink http://forgacslab.missouri.edu/bioprinter.html http://forgacslab.missouri.edu/bioprinter.html
  • 12. Beyond Skin -Scientists are working hard to develop systems to not only print flat tissue, but also blood vessels and organs -The current leaders in the field are companies Organovo and Invetech, which have partnered up to produce the first commercial 3D bioprinter -Advanced models of the bioprinter and newly developed systems allow for more complex and precise printing methods and possibilities -Biological material is able to self organize with use of stem cells Sample rendering of possible model for 3D bioprinter http://www.wired.com/rawfile/2010/07/gallery-bio-printing/
  • 13. -The skin bioprinter has already been successful in treating burns on mice -The 3D bioprinter is already capable of growing arteries -Creators claim that these “printed” arteries could be used in heart bypass surgery in as little as 5 years -More complex organs should be possible in the next 10 years -Careful trials already being conducted over the years Advancements and Possibilities Progress comparison of burn healing rates in mice experiments Petri dish containing a vein produced by bioprinter http://singularityhub.com/2010/11/04/wake-forest-could-print-you-some-new- skin/ http://www.wired.com/rawfile/2010/07/gallery-bio-printing/5/
  • 14. Future Potential -If successful, could reduce or eliminate need for donor organs -Virtually eliminate rejection -Repair or replace any organ -May become the newest tool in hospitals Issues -Much research and testing still required for human application -Many burn victims may not have time to wait for own cells to be grown 3D bioprinter diagram http://www.time.com/time/specials/packages/article/0,28804,2029497_2030617_2029812,00.html
  • 15. LINK- http://www.youtube.com/watch? v=9D749wZSlb0