Your SlideShare is downloading. ×
The History of Pain Medicine
The History of Pain Medicine
The History of Pain Medicine
The History of Pain Medicine
The History of Pain Medicine
The History of Pain Medicine
The History of Pain Medicine
The History of Pain Medicine
The History of Pain Medicine
The History of Pain Medicine
Upcoming SlideShare
Loading in...5

Thanks for flagging this SlideShare!

Oops! An error has occurred.

Saving this for later? Get the SlideShare app to save on your phone or tablet. Read anywhere, anytime – even offline.
Text the download link to your phone
Standard text messaging rates apply

The History of Pain Medicine


Published on

Published in: Health & Medicine
1 Comment
No Downloads
Total Views
On Slideshare
From Embeds
Number of Embeds
Embeds 0
No embeds

Report content
Flagged as inappropriate Flag as inappropriate
Flag as inappropriate

Select your reason for flagging this presentation as inappropriate.

No notes for slide


  • 1. CHAPTER 1 The History of Pain Medicine Winston C. V. Parris and Benjamin Johnson History is a distillation of rumor. sequences of smoking, the trauma associated with THOMAS CARLYLE (1795-1881) automobile accidents, the pathology caused by drug abuse and drug misuse, and the proliferation of viral The management of pain, like the management of illnesses (e.g., acquired immunodeficiency syndrome) disease, is as old as mankind. In the view of Chris- have all contributed further pain and suffering to our tians, the fall of Adam and Eve in the Garden of Eden lot. Therefore any review of history and politics, eco- produced for man (and woman) a long life of suffer- nomics, and social interrelationships of the world is ing disease and pain. This one act allegedly set the inevitably a review of the history of pain. This chapter stage for several disease concepts, including the expe- focuses on some of the major historical events that rience of pain in labor and delivery; the concept that have influenced pain, its development, and its man- hard work is painful; the notion that blood, sweat, agement and highlights the important phases that and tears are needed to produce fruit; the introduc- led to the current conceptualization of pain and its tion of pain and disease to human existence; the treatment as an independent specialty in modern establishment of the fact that hell and its fires are medicine. painful; and the expectation that heaven is pure, delightful, spiritually pleasing, and, of course, pain- PAIN AND RELIGION free. In these concepts, pain is viewed as a negative experience and one that is associated with disease, The early concept of pain as a form of punishment morbidity, and the dying process. Most diseases, from supreme spiritual beings for sin and evil activity including infections, plagues, metabolic disorders is as old as mankind.1 In the book of Genesis, God (e.g., diabetes mellitus), endocrine disorders, hyper- told Eve that following her fall from grace, she would tension, and cancer, of course, afflict mankind spon- endure pain during childbirth: “I will greatly multi- taneously and usually cause significant pain, without ply your pain in childbearing; in pain you shall bring any wrongdoing, negligence, or irresponsibility on forth children, yet your desire shall be for your the part of the afflicted person. husband and he shall rule over you” (Genesis 3:16). As we consider the historical perspective, humans This condemnation led early Christians to accept have deliberately and knowingly inflicted on one pain as a normal consequence of Eve’s action and to another many experiences associated with pain— view this consequence as being directly transferred from the earliest wars to the more recent irrational to them. Thus any attempt to decrease the pain asso- shooting incidents in the Arkansas and Oregon public ciated with labor and delivery was treated by early school systems, from the scourging of Jesus to the Christians with disdain and disapproval. It was not contemporary strife in the Middle East, the Rwandan until 1847, when Queen Victoria was administered genocide, the Irish “religious” fratricide, and the con- chloroform by James Simpson2 for the delivery of her flicts in Bosnia and the Balkans. All wars, including eighth child, Prince Leopold, that contemporary the great wars, World War I and World War II, the Christians, and in particular Protestants, accepted American Civil War, the Korean War, and the the notion that it was not heretical to promote pain- Vietnam War, have all been associated with untold less childbirth as part of the obstetric process. pain, suffering, and death. From the Old Testament, Job has been praised for Although we as human beings have not learned his endurance of pain and suffering. Yet, Job’s friends from these painful episodes and continue to inflict wondered whether these tribulations were an indica- pain on others, the advances and increasing sophis- tion that he had committed some great sin for which tication of the 21st century have brought about new God was punishing him. Their justification for concepts of disease and the painful states that dis- this assumption was based in the book of Proverbs, eases produce. The social illnesses—veneral diseases, which suggested that “no harm befalls the righteous” the pulmonary, cardiovascular, and neoplastic con- (Proverbs 12:21). Notwithstanding, Job was consid- 3
  • 2. 4 General Considerations ered a faithful servant by God and was not guilty of from Georgia into Texas. Although surgical anesthe- any wrongdoing. In fact, he was described as a man sia was well developed by the late 19th century, reli- who was “blameless and upright” and one who feared gious controversy over its use required Pope Pius XII God and turned away from evil.3 to give his approval before anesthesia could be exten- In the 5th century, St. Augustine wrote that “all sively used for surgical procedures.6 Pope Pius XII diseases of Christians are to be ascribed to demons; wrote, “The patient, desirous of avoiding or relieving chiefly do they torment the fresh baptized, yea, even pain, may without any disquietude of conscience, the guiltless newborn infant,” implying that not use the means discovered by science which in them- even innocent infants escaped the work of demons. selves are not immoral.” Today, major typhoons, hurricanes, fires, earth- quakes, volcanoes, tsunamis, floods, droughts, and PAIN AND THE ANCIENT CULTURES fires destroy hundreds, and at times thousands, of innocent, defenseless people. One ponders the ratio- Disease, pain, and death have always been consid- nale of such pain and suffering endured by otherwise ered undesirable. The principles on which medicine good people while seemingly ruthless and evil persons was founded were based on measures to overcome apparently triumph and prosper in an atmosphere of human suffering from disease. Thus pain was usually luxury and comfort. thought of as either emanating from an injury or This paradox can be discouraging at times but is originating from the dysfunction of an internal organ usually upheld by firm Christian belief. In the 1st or system. Traditionally, pain after physical injury century, many people who belonged to the Catholic (e.g., a gunshot wound or spear injury) was not con- Church were rebuked and suffered ruthless persecu- sidered problematic, since as soon as the offending tion, including death, because of their belief in Jesus injurious agent was removed or once the conse- as the Messiah. Some who were subsequently de- quences of the offending injury were corrected, the scribed as martyrs endured their suffering with the patient either recovered rapidly or, on occasion, belief that they did it for the love of Christ, and they died.7 On the other hand, pain from disease (e.g., the felt that their suffering identified them with Christ’s pain of an inflamed gallbladder or ruptured appen- suffering on the cross during his crucifixion.4 This dix) was regarded with more mystique, and treat- may be the earliest example of the value of psycho- ment was usually tinged with superstitious tradition. therapy as an important modality in managing pain. The tribal concept of pain came from the belief that Thus many present-day cancer patients with strong it resulted from an “intrusion” from outside the Christian beliefs view their pain and suffering as part body. These “intruders” were thought to be evil of their journey toward eternal salvation. This spirits sent by the gods as a form of punishment. It concept has led to several scientifically conducted was in this setting that the role of medicine men and and government-sponsored studies evaluating inter- shamans flourished, because these were the persons cessory prayer as an effective modality for controlling assigned to treat the pain syndromes associated with cancer pain. internal disease. Because it was thought that spirits To fully appreciate the historical significance of entered the body by different avenues, the rational pain, it is important to reflect on the origins of the approach to therapy was aimed at blocking the par- “pain patient.” The word pain comes from the Latin ticular pathway chosen by the spirit. word poena, which means “punishment.” The word In Egypt, the left nostril was considered the specific patient is derived from the Latin word patior, meaning site where disease entered. This belief was confirmed “to endure suffering or pain.” Thus it is not too out- by the Papyri of Ebers and Berlin,8 which stated that rageous to appreciate that, in ancient days, persons the treatment of headache involved expulsion of the who experienced pain were interpreted to have offending spirit by sneezing, sweating, vomiting, uri- received punishment in the form of suffering that nation, and even trephination. In New Guinea, it was was either dispensed by the gods or offered up to believed that evil spirits entered via a spear or an appease the gods for transgressions.5 arrow that then produced spontaneous pain.7 Thus As epidural anesthesia has developed and the tech- it was common for the shaman to occasionally purge niques have been refined so that mortality and the evil spirit from a painful offending wound and morbidity are negligible, childbirth and delivery are neutralize it with his special powers or his special increasingly considered relatively painless in most medicines. Egyptians treated some forms of pain by developed societies. Unfortunately, in many coun- placing an electric fish from the Nile over the wounds tries neither the personnel nor the technology is in order to control the pain.9 The resulting electrical available and resources to provide such personnel stimulation that produced pain relief actually works and technology are inadequate, making childbirth a by a mechanism similar to transcutaneous electrical primitively painful and at times disastrous event. The nerve stimulation, which is frequently used today to history of anesthesia is full of instances wherein treat pain. attempts to relieve pain were initially met with resis- The Papyrus of Ebers, an ancient Egyptian manu- tance and at times violence. In the mid-19th century, script, contains a wide variety of pharmacologic Crawford Long of Georgia attempted to develop and information and describes many techniques and provide anesthesia, but contemporary Christians of recipes, some of which still have validity.8 The Papyri that state considered him a heretic for his scholarly describe the use of opium for the treatment of pain activity. As a result, he literally had to flee for his life in children. Other concoctions for treating pediatric
  • 3. The History of Pain Medicine 5 pain have included wearing amulets filled with a While these advances were taking place, there were dead man’s tooth (Omnibonus Ferraruis, 1577) as a simultaneous advances in the development of thera- treatment for teething pain. Although early docu- peutic modalities, including the use of drugs (e.g., ments specifically address the management of pain opium) as well as heat, cold, massage, trephining, in children, it is unfortunate that even today the and exercise to treat painful illnesses. These develop- treatment of pediatric pain is far from optimal. This ments brought about the establishment of the prin- glaring deficiency was highlighted in 1977 by Eland, ciples of surgery for treating disease. Electricity was who demonstrated that in a population of children first used by the Greeks of that era as they exploited 4 to 8 years of age, only 50% received analgesics for the power of the electrogenic torpedo fish (Scribonius postoperative pain.3 The results are even more unsat- longus) to treat the pain of arthritis and headache. isfactory for the treatment of chronic pain and cancer Electrostatic generators were used in the late Middle pain in children. It is unfortunate that the observa- Ages, as was the Leyden jar; these developments tions of earlier scholars have been ignored. Two erro- resulted in the reemergence of electrotherapy as a neous assumptions—that (1) children are less sensitive modality for managing medical problems, including to pain and (2) the central nervous system is rela- pain. There was a relative standstill in the develop- tively undeveloped in neonates—are partially respon- ment of electrotherapy as a medical modality until sible for this deficiency. the invention of the electric battery in the 19th Early Native Americans believed that pain was century. Then several attempts were made to revive experienced in the heart, whereas the Chinese identi- its use as an effective medical modality, but these fied multiple points in the body where pain might concepts did not catch on and were largely used originate or might be self-perpetuating.10 Conse- only by charlatans and obscure scientists and prac- quently, attempts were made to drain the body of titioners. Throughout the Middle Ages and the these “pain points” by inserting needles, a concept Renaissance, debate raged regarding the origin and that may have given birth to the principles of acu- processing center of pain. Fortunes fluctuated be- puncture therapy, which is well over 2000 years tween proponents of the brain theory and pro- old.11 ponents of the heart theory, depending on which The ancient Greeks were the first to consider pain theory was favored. to be a sensory function that might be derived from Heart theory proponents appeared to prosper when peripheral stimulation.12 In particular, Aristotle William Harvey, recognized for his discovery of the believed that pain was a central sensation arriving circulation, supported the heart as the focus for pain from some form of stimulation of the flesh, while sensation. Descartes disagreed vehemently with the Plato hypothesized that the brain was the destination Harvey hypothesis, and his description of pain con- of all peripheral stimulation.1 Aristotle advanced the duction from peripheral damage through nerves to notion that the heart was the originating source or the brain led to the first plausible pain theory, that processing center for pain. He based his hypothesis is, the specificity theory.16 It is interesting to note that on the concept that an excess of vital heat was con- the specificity theory followed Descartes’ description ducted by the blood to the heart where pain was by some 2 centuries. Several other theories followed modulated and perceived. Because of his great repu- the specificity theory and contributed to the founda- tation, many Greek philosophers followed Aristotle tion for understanding pain and pain mechanisms. and embraced the notion that the heart was the center for pain processing.13 Another Greek philoso- PAIN AND PAIN THEORIES pher, Stratton, and other distinguished Egyptians, including Herophilus and Eistratus, disagreed with The specificity theory, originally proposed by Des- Aristotle and proposed the concept that the brain cartes, was formally revised by Schiff based on animal was the site of pain perception as suggested by Plato. research. The fundamental tenet of the theory was Their theories were reinforced by actual anatomic that each sensory modality, including pain, was studies showing the connections of the peripheral transmitted along an independent pathway. By and central nervous systems.14 examining the effect of incisions in the spinal cord, Notwithstanding, controversies between the oppos- Schiff16 demonstrated that touch and pain were inde- ing theories of the brain and the heart as the center pendent sensations. Furthermore, he demonstrated for pain continued, and it was not until 400 years that sectioning of the spinal cord deferentially later that the Roman philosopher Galen rejuvenated resulted in the loss of one modality without affect- the works of the Egyptians Herophilus and Eistratus, ing the other. Further work along the same lines by and greatly reemphasized the model of the central Bliz,17 Goldscheider,18 and von Frey19 contributed to nervous system. Although Galen’s work was compel- the concept that separate and distinct receptors ling, he received little recognition for it until the existed for the modalities of pain, touch, warmth, 20th century. and cold. Toward the period of the Roman Empire, steady During the 18th and 19th centuries, new inven- progress was made in understanding pain as a sensa- tions, new theories, and new thinking emerged. This tion similar to other sensations in the body. Develop- period was known as the Scientific Revolution, and ments made in anatomy, and to a lesser extent several important inventions took place, including physiology, helped establish that the brain, not the the discovery of the analgesic properties of nitrous heart, was the center for the processing of pain.15 oxide, followed by the discovery of the local anes-
  • 4. 6 General Considerations thetic agents (e.g., cocaine). The study of anatomy Dryden once wrote, “For all the happiness mankind was also developing rapidly as an important branch can gain is not in pleasure, but in rest from pain.” of science and medicine; most notable was the dis- Thus many fatal nonpainful diseases are not as feared covery of the anatomic division of the spinal cord as relatively trivial painful ones. into sensory (dorsal) and motor (ventral) divisions. Throughout the ages, physicians and healers have In 1840, Mueller proposed that, based on anatomic focused their attention on managing pain. Thus in studies, there was a straight-through system of spe- managing cancer, an important measure of success- cific nerve energies in which specific energy from a ful treatment is the success with which any associ- given sensation was transmitted along sensory nerves ated pain is managed. Although many technologic to the brain.20 Mueller’s theories led Darwin to advances have been made in medicine, it is only propose the intensive theory of pain,21 which main- within the past 10 to 20 years that significant strides tained that the sensation of pain was not a separate have been made to deal with chronic pain as a disease modality but instead resulted from a sensory over- entity per se—one requiring specialized study, spe- load of sufficient intensity for any modality. This cialized evaluation, and specialized therapeutic inter- theory was modified by Erb22 and then expanded by ventions. As better techniques and more effective Goldscheider18 to encompass the roles of both stimu- methods for evaluation and treatment of pain, espe- lus intensity and central summation of stimuli. cially chronic pain, are developed, the management Although the intensive theory was persuasive, the of this disease will be considered more complete and controversy continued, with the result that by the an important supplement to the great strides made mid-20th century, the specificity theory was univer- in other areas of chronic disease management. sally accepted as the more plausible theory of pain. With this official blessing (although it was not PAIN IN THE 20TH CENTURY unanimous) of the contemporary scientific commu- nity, strategies for pain therapy began to focus on General anesthesia was formally discovered by identifying and interrupting pain pathways. This William Morton in 1846; in 1847, Simpson used tendency was both a blessing and a curse. It was a chloroform to provide anesthesia for labor and deliv- blessing in that it led many researchers to explore ery.9 Around the same time, the needle and the surgical techniques that might interrupt pain path- syringe were invented. Many local anesthetic agents ways and consequently relieve pain, but it was a were also discovered in that era. In 1888, Corning curse in that it blind-sided the medical community described the use of a local anesthetic, cocaine, for for more that half a century into believing that pain the treatment of nerve pain. Techniques for local and pathways and their interruption were the total answer regional anesthesia for both surgery and pain disor- to the pain puzzle. This trend was begun in the late ders proliferated rapidly. 19th century by Letievant, who first described spe- In 1907, Schlosser reported significant relief of cific neurectomy techniques for treating neuralgic neuralgic pain for long periods with alcohol injection pain.23 Afterward, various surgical interventions for of damaged and painful nerves. Reports of similar chronic pain were developed and used, including treatment came from the management of pain result- rhizotomy, cordotomy, leucotomy, tractotomy, my- ing from tuberculous and neoplastic invasion.25 In elotomy, and several other operative procedures 1926 and 1928, Swetlow and White, respectively, designed to interrupt the central nervous system and reported on the use of alcohol injections into tho- consequently reduce pain.24 Most of these techniques racic sympathetic ganglia to treat chronic angina. In were abysmal failures that not only did not relieve 1931, Dogliotti described the use of alcohol injected pain but also on occasion produced much more pain into the cervical subarachnoid space to treat pain than was previously present. A major consequence associated with cancer.26 lingers today—the notion that pain can be “fixed” One consequence of war has been the develop- by a surgical procedure or other modality. ment of new techniques and procedures to manage injuries. In World War I (1914-1918), numerous inju- PAIN AND DISEASE ries were associated with trauma (e.g., dismember- ment, peripheral vascular insufficiency, and frostbite). The cardinal features of disease as recognized by early In World War II (1939-1946), not only peripheral philosophers included calor, rubor, tumor, and dolor; vascular injuries but also phantom limb phenomena, the English translation is heat, redness, swelling, and causalgias, and many sympathetically mediated pain pain. One of the important highlights in the history syndromes occurred. Leriche developed the tech- of pain medicine was the realization that even though nique of sympathetic neural blockade with procaine heat, redness, and swelling may disappear, pain can to treat the causalgic injuries of war.27 John Bonica, continue long after and be unresponsive on occasion himself an army surgeon during World War II, rec- to different therapeutic modalities. When pain con- ognized the gross inadequacy of managing war inju- tinues long after the natural pathogenetic course of ries and other painful states of veterans with the disease has ended, a chronic pain syndrome develops existing unidisciplinary approaches.28 This led him with characteristic clinical features, including depres- to propose the concept of a multidisciplinary, multi- sion, dependency, disability, disuse, drug misuse, modal management for chronic pain. Bonica also drug abuse, and, of course, “doctor shopping.” John highlighted the fact that pain of all kinds was being
  • 5. The History of Pain Medicine 7 undertreated; his work has borne fruit, in that he is on the theory but also to the maturity of pain medi- universally considered the “father of pain,” and he cine as a science.30 As a consequence, the American was the catalyst for the formation of many estab- Pain Society, the American Academy of Pain Medicine, lished national and international pain organizations. the IASP, and the World Institute of Pain (WIP) flour- The clinic he developed at the University of Wash- ish today as serious and responsible organizations ington in Seattle remains a model for the multidisci- dealing with various aspects of pain medicine, includ- plinary management of chronic pain. As a result of ing education, science, certification, and credential- his work, the American Pain Society and the Interna- ing of members of the specialty of pain medicine. tional Association for the Study of Pain (IASP) have been formed, are still active, and continue to lead in PAIN AND THE IMPACT OF PSYCHOLOGY pain research and pain management. Bonica’s lasting legacy is the historic volume The Management of Pain, The history of pain medicine would be incomplete published in 1953. without acknowledging the noteworthy contribu- Anesthesia as a specialty developed but was still tions of psychologists. Their influential research and associated with significant mortality and morbidity. clinical activities have been an integral part of a revo- Anesthesia departments were considered divisions of lution in the conceptualization of the pain experi- surgery, not reaching full autonomy until after World ence.31 For example, in the early 20th century, the War II. Because of morbidity associated with general role of the cerebral cortex in the perception of pain anesthesia and because several new local anesthetics was controversial, due to a lack of understanding of were being discovered, regional anesthesia and its neuroanatomic pathways and the neurophysiologic associated techniques began to flourish in the United mechanisms involved in pain perception.32,33 This States. Bonica also played a major role in advancing controversy largely ended with the introduction of the use of epidural anesthesia to manage the pain the gate control theory by Wall and Melzack in associated with labor and delivery. Regional anesthe- 1965.29 The gate control theory has stood the test of sia suffered a significant setback in the United time, in that subsequent research using modern Kingdom with the negative publicity surrounding brain imaging techniques such as PET, fMRI, and the 1954 cases of Wooley and Roe, who suffered SPECT has also described the activation of mul- serious and irreversible neurologic damage after tiple cortical and subcortical sites of activity in the spinal anesthesia. It took 3 more decades to fully brain during pain perception. Further elaboration of overcome that setback and to see regional anesthesia the psychological aspects of the pain experience widely accepted as safe and effective in the United includes the three psychological dimensions of pain: Kingdom. Several persons contributing significantly sensory-discriminative, motivational-affective, and to the development of regional anesthesia are cognitive-evaluative.34 Corning, Quincke-August Bier, Pitkin, Etherington- Psychological researchers have greatly advanced Wilson, Barker, and Adriani. the field of pain medicine by reconceptualizing both As recent society has developed and as science has the etiology of the pain experience and the treatment prospered, the general public has come to consider strategy. Early pain researchers conceptualized the pain to be unsatisfactory and unacceptable. As a pain experience as a product of either somatic pathol- result, demands have been made that resulted in the ogy or psychological factors. However, psychological development of labor and delivery anesthesia ser- researchers have convincingly challenged this mis- vices, acute pain services, and, more recently, chronic conception by presenting research that illustrates the pain clinics. Bonica’s vision was not only the devel- complex interaction between biomedical and psy- opment of those clinics but also the founding and chosocial factors.35-37 maintenance of national and international pain This biopsychosiocial approach to the pain experi- organizations to promote research and scientific ence encourages the realization that pain is a complex understanding of pain medicine. As a result, a tre- perceptual experience modulated by a wide range of mendous amount of research continues, almost qua- biopsychosocial factors, including emotions, social drupling each year. and environmental contexts, and cultural back- An outstanding contribution in the field of research ground, as well as beliefs, attitudes, and expectations. was the development and publication of the gate As the acutely painful experience transitions into a control theory by Melzack and Wall in 1965.29 This chronic phenomenon, these biopsychosocial abnor- theory, built on the preexisting and prevalent specific- malities develop permanency. Thus, chronic pain ity and intensive theories, provided a sound scientific affects all facets of a person’s functional universe, at basis for understanding pain mechanisms and for great expense to the individual and society. Conse- developing other concepts on which sound hypothe- quently, logic dictates that this multimodal etiology ses could be developed. The gate control theory of pain requires a multimodal therapeutic strategy emphasizes the importance of both of ascending and for opti-mal cost-effective treatment outcomes.38,39 descending modulation systems and laid down a solid Additional contributions from the field of psychol- framework for the management of different pain syn- ogy include therapeutic behavioral modification dromes. The gate control theory almost single-hand- techniques for the management of pain. Such tech- edly legitimized pain as a scientific discipline, leading niques as cognitive behavioral intervention, guided not only to many other research endeavors building imagery, biofeedback, and autogenic training are the
  • 6. 8 General Considerations direct results of using the concepts presented in the chronic pain assessment and management especially gate control theory. In addition, neuromodulatory in developing countries. Cancer pain awareness and therapeutic modalities such as transcutaneous elec- its management have been noteworthy contributions trical nerve stimulation (TENS), peripheral nerve of the IASP. stimulation, spinal cord stimulation, and deep brain Special interest groups (SIGs) within the IASP have stimulation are also logical offspring of the concepts successfully promoted research, understanding, edu- presented in the gate control theory. cation, and enhanced pain management of the par- The evaluation of candidates for interventional ticular special interest. Areas of interest include pain medical procedures is another valuable historical in children, neuropathic pain, herbal medicine, and contribution from the field of psychology. Not only neuropathic pain, among others. The IASP also pro- is the psychologist’s expertise in the identification of motes and administers Chronic Pain Fellowship pro- appropriate patients valuable for the success of thera- grams for deserving candidates all over the world. peutic procedural interventions in the management of pain, but his or her expertise is helpful in identify- The American Pain Society ing patients who are not appropriate candidates for procedural interventions. Thus, psychologists have Spurred by a burgeoning public interest in pain man- contributed positively toward the cost-effectiveness agement and research as well as the formation of the and usefulness of diagnostic and therapeutic pain Eastern and Western USA Chapters of the IASP, the medicine. American Pain Society (APS) was formed in 1977 as a result of a meeting of the Ad Hoc Advisory Com- PAIN AND PAIN INSTITUTIONS mittee on the Formation of a National Pain Organiza- tion. The need for a national organization of pain The International Association for the Study of Pain professionals was realized as growth of the IASP con- tinued. The APS became the first national chapter of The IASP is the largest multidisciplinary international the IASP, and has constituent regional and state association in the field of pain. Founded in 1973 chapters. The APS has its own journal, The Journal of by John J. Bonica, MD, the IASP is a nonprofit Pain, and holds national meetings. Its main function professional organization dedicated to furthering is to carry out the mission of the IASP on a national research on pain and improving the care of patients level. experiencing pain. Membership is open to scientists, physicians, dentists, psychologists, nurses, physical Commission on the Accreditation of therapists, and other health professionals actively Rehabilitation Facilities engaged in pain, and to those who have special inter- est in the diagnosis and treatment of pain. The IASP As pain clinics developed, it became clear that there has members in more than 100 national chapters. was a need for credentialing, not only of pain centers The goals and objectives of IASP are to foster and and pain clinics, but also of pain clinicians. In 1983, encourage research of pain mechanisms and pain the Commission on Accreditation of Rehabilitation syndromes, and to help improve the management of Facilities (CARF) was the first to offer a system of patients with acute and chronic pain by bringing accreditation for pain clinics and pain treatment together scientists, physicians, and other health pro- centers. The CARF model was based on the rehabilita- fessionals of various disciplines and backgrounds tion system, and it quickly became clear that the who have interest in pain research and management. orientation of CARF would be physical and psycho- The goals of the IASP also include mandates to social rehabilitation of patients suffering pain in con- promote education and training in the field of pain, trast to modality treatment to reduce pain sensation. as well as to promote and facilitate the dissemination CARF standards mandated that multidisciplinary of new information in the field of pain. One of the pain management programs offer medical, psycho- instruments of dissemination is sponsorship of the logic, and physical therapy modalities for pain man- journal Pain. In addition, the IASP promotes and agement. Pain clinicians were not accredited by sponsors a highly successful triennial World Con- CARF, and it quickly became apparent that one could gress as well as other meetings. IASP encourages the have an accredited pain center without having development of national chapters for the national accredited pain clinicians. The CARF model gained implementation of the international mission of the modest acceptance among insurance carriers and IASP. The IASP also encourages the adoption of a third-party payers, primarily because of its emphasis uniform classification, nomenclature, and definition on accountability and program evaluation. Its major regarding pain and pain syndromes. The develop- goals included such objective measures as increased ment of a uniform records system in regard to infor- physical function, reduced medication intake, and mation relating to pain mechanisms, syndromes, and return-to-work issues. management is also a stated goal of the IASP, and education of the general public to the results and The American Academy of Pain Medicine implications of current pain research is another mission of the IASP. As CARF gained prominence, many pain clinicians The IASP has partnered with the World Health realized that neither CARF nor the APS completely Organization (WHO) in providing guidelines for met their practice and professional needs. Further-
  • 7. The History of Pain Medicine 9 more, it became obvious that there was a major defi- for eligible physicians. Among the many criteria, ciency in evaluating the competence of pain the minimum criterion is that candidates be ABMS physicians, in that there were no uniform standards board-certified in their primary specialty. for training and credentialing of these pain clini- 3. The establishment of The Clinical Journal of Pain, cians. Thus in 1983, at a meeting of the APS in which initially served as the official journal of Washington, DC, a group of physicians (of whom AAPM and has now been replaced with the journal chapter author Winston Parris was privileged to be a Pain Medicine. member) formed the American Academy of Algology Additional goals include an attempt to establish (the term algology is derived from the word algos uniform practice parameters and outcome measures [Greek for “pain”], and logos [Greek for “study”]). The for different pain modalities. name was changed 2 years later to the American Academy of Pain Medicine (AAPM), a name that is The American Board of Pain Medicine more acceptable in mainstream medicine. This academy was formed to meet the needs and The ABPM is the examination division of the AAPM, aspirations of pain physicians in the United States. Its which serves the public by improving the quality of major focus was to address the specific concerns of pain medicine through certification of pain special- pain physicians and to enhance, authenticate, develop, ists. It evaluates candidates who voluntarily appear and lead to the credentialing of pain medicine special- for examination after a credentialing process and cer- ists. As a medical specialty society, the academy is tifies them as diplomates in pain medicine if they suc- involved in education, training, advocacy, and cessfully pass the examination process. This mission research in the specialty of pain medicine. The prac- serves the public by helping ensure that the physi- tice of pain medicine is multidisciplinary in approach, cians passing the examination have an approved incorporating modalities from various specialties to level of expertise and currency of knowledge in pain ensure the comprehensive evaluation and treatment medicine. More than 2000 physicians have become of the pain patient. AAPM represents the diverse scope diplomates of the ABPM. of the field through membership from a variety of origins, including such specialties as anesthesiology, The American Society of Regional Anesthesia internal medicine, neurology, neurologic surgery, and Pain Medicine orthopedic surgery, physiatry, and psychiatry. The goals of the AAPM include the promotion of quality The American Society of Regional Anesthesia (ASRA) care of both patients experiencing pain as a symptom is the preeminent society on regional anesthesia. The of a disease and patients with the primary disease of society is based in the United States; other societies pain through research, education, and advocacy, and on regional anesthesia are based in Europe, Asia, and the advancement of the specialty of pain medicine. Latin America. Cognizant of the fact that anesthe- As we enter the managed care era, it is clear that siologists comprise the majority of pain medicine issues such as reimbursement, contract negotiations, practitioners and interventional pain physicians and fee scheduling, practice management, mergers, acqui- perform translational and clinical research, the ASRA sitions, and other business-related matters are becom- started another annual meeting dealing exclusively ing increasingly important to pain practitioners. The with pain medicine. The annual meeting of the ASRA political and business arms of the American Academy that deals with regional anesthesia is held in the of Pain Medicine are becoming instrumental in spring, whereas their annual meeting on pain medi- helping guide physicians through the murky waters cine is held in the fall. To better fulfill its mission, of managed care and pain medicine. the ASRA has changed its name to the American In an attempt to provide creditable credentialing Society of Regional Anesthesia and Pain Medicine in pain medicine, the AAPM sponsored the American and the name of their highly cited journal, Regional College of Pain Medicine (ACPM), which organized, Anesthesia, to Regional Anesthesia and Pain Medicine. developed, and administered the first credentialing The journal is the official publication of the examination in 1992. Successful candidates received American, European, Asian and Oceanic, and Latin the Fellowship of the American College of Pain Medi- American Societies of Regional Anesthesia. cine. In the process of attempting to receive recogni- tion of the American Board of Medical Specialties The American Society of Interventional (ABMS), the name was changed on the recommenda- Pain Physicians tion of the ABMS to the American Board of Pain Medicine (ABPM). The American Society of Interventional Pain Physi- Since the development of AAPM, most of the orga- cians (ASIPP) is a national organization representing nization’s goals have been met: the interests of interventional pain physicians in the 1. The successful lobbying for a seat for pain medicine United States. The society was founded in 1998 by in the House of Delegates of the American Medical Dr. Laxmaiah Manchikanti and associates for the Association (AMA). purpose of improving the delivery of interventional 2. The successful establishment of a credentialing pain management services to patients across the body, the American Board of Pain Medicine United States, whether in hospitals, ambulatory sur- (formerly the American College of Pain Medicine), gical centers, or medical offices. The ASIPP has an which offers annual credentialing examinations active political action committee, which has been
  • 8. 10 General Considerations instrumental in achieving numerous legislative vic- ship and an online University of Integrated Studies tories benefiting its constituents and their patients. that offers graduate-level online courses for health The goals of the ASIPP include the preservation practitioners. In addition, there are various levels of of insurance coverage, coverage for interventional pain credentialing available depending on the level pain procedures, the advancement of patient safety, of education of the student/practitioner. advancement of cost-effectiveness, and establish- ment of accountability in the performance of inter- American Society for Pain Management Nursing ventional procedures. Also included in the goals of the ASIPP are the pursuit of excellence in education Founded in 1990, the American Society for Pain in interventional pain management, the improve- Management Nursing (ASPMN) is an organization of ment of practice management, the enhancement of professional nurses dedicated to promoting and pro- regulatory compliance, and the elimination of fraud viding optimal care of individuals with pain through and abuse. The ASIPP journal is indexed and called education, standards, advocacy, and research. Their Pain Physician. goals include providing access to specialized care for patients experiencing pain, providing education of The American Academy of Hospice and the public regarding self-advocacy for their pain Palliative Medicine needs, and providing a network for nurses working in the pain management field. This society also spon- The American Academy of Hospice and Palliative sors educational conferences and is formulating a Medicine (AAHPM) was founded in 1988 to advance means of adding compensational value to the spe- the specialty of hospice medicine in the United cialty of pain management nursing. States. The academy’s goals include providing educa- tion and clinical practice standards, fostering research, The National Headache Foundation facilitating personal and professional development, and sponsoring public policy advocacy for the termi- Founded in 1970, the National Headache Foundation nally ill and their families. The academy’s philoso- (NHF) works to create an environment in which phy includes the belief that the proper role of the headaches are viewed as a legitimate health problem. physician is to help the sick, even when cure is not The foundation’s goals include the promotion of possible. In addition, the academy aims to help research into the causes and treatment of headache, patients achieve an appropriate and easy passage to and the education of the public regarding the legiti- death as one of the most important and rewarding macy of headaches as a biologic disease. services that a physician can provide. The academy endorses the philosophy that the medical profession The World Institute of Pain should attend to all the needs of the dying patient and family, and should encourage and promote The World Institute of Pain (WIP) is an international patient autonomy. organization that aims to promote the best practice of pain medicine throughout the world. Its goals are The American Academy of Orofacial Pain to educate and train personnel of member pain centers by the utilization of local hands-on training The American Academy of Orofacial Pain (AAOP) is international seminars and exchange of clinicians. an organization of health care professionals dedi- Updating member pain centers with state-of-the-art cated to the alleviation of pain and suffering through pain information via newsletters, scientific seminars, education, research, and patient care in the field of and journal and book publications are additional orofacial pain and associated disorders. Goals of the goals. One of the most important goals of WIP is to AAOP include the establishment of acceptable crite- develop an international examination process for ria for the diagnosis and treatment of orofacial pain testing and certifying qualified interventional pain and temporomandibular disorders, sponsorship of physicians. Showing proficiency in both general pain annual meetings and a medical journal, and en- knowledge and the safe performance of interven- couragement for the study of orofacial pain and tional procedures, the successful candidates are tempo-romandibular disorders at undergraduate and awarded the designation of fellow of interventional postgraduate levels of dental education. pain practice (FIPP). The journal of the WIP, Pain Practice, is indexed. The American Academy of Pain Management The World Society of Pain Clinicians The American Academy of Pain Management (AAP Management), founded in 1988, is an inclusive inter- The World Society of Pain Clinicians (WSPC) is an disciplinary organization serving clinicians who treat international organization whose goals are to bring people with pain through advocacy and education, together clinicians with a common interest in the and by setting standards of care. The AAP Manage- treatment of pain. Also, the goals are to stimulate ment is open to a diverse group of pain clinicians, education and learning in the field of pain, and to and emphasizes inclusivity of all health care special- encourage the dissemination of information on pain ties. The organization boasts a large, diverse member- throughout the world. The WSPC also endorses and
  • 9. The History of Pain Medicine 11 encourages the audit and scientific research on all PAIN AND THE HOSPICE MOVEMENT aspects of pain, especially treatment. The WSPC sponsors a biannual international congress of clinical Hospice is a medieval term representing a welcome aspects of pain and has its own journal, Pain Clinic. place of rest for pilgrims to the Holy Land. The concept of hospice dates back to the reign of Emperor Julian The International Spine Interventional Society the Apostate when Fabiola, a Roman matron, created a place for sick and healthy travelers and cared for The International Spine Interventional Society (ISIS) the dying.40 Hospitals in general were regarded as is a society of physicians interested in the develop- Christian institutions, and in medieval times, most ment, implementation, and standardization of per- hospitals were used as hospices and vice versa.41 cutaneous techniques for precision diagnosis of During the 11th century, several hospices were spinal pain. The organization sponsors forums for based in and operated by monasteries. The 17th exchange of ideas, encourages research undertaking, century Catholic priest St. Vincent DePaul founded and holds public lectures. The mission of ISIS includes the Sisters of Charity in Paris as a home for the poor, the consolidation of developments in diagnostic the sick, and the dying. St. Vincent DePaul’s work for needle procedures, the identification and resolution the poor and the sick created a significant impact not of controversies, the public dissemination of devel- only on the Catholic Church but also on other con- opments, and the recommendation of standards of temporary religions. The Protestant pastor Fliedner practice based on scientific data. was so influenced that he founded Kaiserwerth 100 years later. Nuns from the Sisters of Charity and The International Neuromodulation Society Kaiserwerth accompanied Florence Nightingale to Crimea to care for wounded soldiers and other citi- Founded in 1989, the International Neuromodula- zens who were either sick or dying.42 tion Society (INS) is a multidisciplinary international In 1902, the Irish Sisters of Charity founded St. society promoting therapeutic neuromodulation at a Joseph’s Hospice, staffed by Cecily Saunders 50 years clinical and scientific level. The primary means of later. Dr. Saunders was the first full-time hospice exchanging knowledge consist of regular scientific medical officer, and she was regarded as the founder meetings and the journal Neuromodulation. The first and medical director of St. Christopher’s Hospice in national chapter of the INS was the American Neu- England. She was initially trained as a nurse and romodulation Society. served in the Second World War. After she became injured, she received training as a medical social worker. She subsequently developed a keen interest American Pain Foundation in terminal cancer patients and underwent training in medical school to become a physician. She empha- Founded in 1997 by three past presidents of the APS, sized the importance of taking the patient at his or the American Pain Foundation (APF) is an indepen- her word during pain assessment and scheduling the dent, nonprofit, grassroots organization serving dosing of opioids on a time-contingent basis as com- people with pain through information, advocacy, pared to an as-needed dosing schedule. She also and support. Its goals include serving as an informa- advocated the need for frequent pain assessments so tion clearinghouse for people with pain, promoting as to effectively manage cancer patients’ pain. In recognition of pain as a critical health issue, and addition, she sought to convince the medical com- advocating for changes in professional training regu- munity that it was totally unnecessary and inhu- latory policies and health care delivery systems to mane for cancer patients to die in pain.43 For all her ensure that people with pain have access to proper efforts and leadership, she is regarded as the “mother medical care. The APF was the first pain organization of palliative care” and was knighted for her contribu- specifically formed to serve the interests of people tions to the hospice movement and the care of the experiencing pain associated with diverse disorders dying cancer patient. Dame Saunders’ views and associated with the presence of significant pain. works are widely taught in medical and nursing schools today and form the basis of palliative care. The National Pain Foundation Founded in 1998, the National Pain Foundation PAIN AND THE FUTURE (NPF) seeks to advance the recovery of persons in pain through education, information, and support. Pain medicine has come a long way. A review of the The NPF empowers patients by helping them become history of pain demonstrates that until the time of actively involved in the design of their treatment Bonica, pain management was considered to be uni- plan. The organization’s website has interactive fea- modal, unidisciplinary, and largely managed haphaz- tures that encourage patients to identify the informa- ardly and without any clear structural organization. tion that they need to manage their pain in the most Today, new drugs, innovative techniques, and cre- understandable way. The NPF strives to fill the gap ative procedures have expanded the scope of pain in the understanding, awareness, and accessibility of medicine. In addition, new research is contributing pain treatment options. daily to modern concepts of pain and its manage-
  • 10. 12 General Considerations ment; these concepts are having positive effects on 11. Veith I: Huang Ti Ne Ching Su Wen. Baltimore, William & the development of pain medicine. Wilkins, 1949. 12. Bonica JJ: Evolution of pain concepts and pain clinics. In The contributions of the IASP, the WSPC, the Brena SF, Chapman SL (eds): Clinics in Anesthesiology: AAPMed, the APS, and the many other international, Chronic Pain: Management Principles 1985;3:1. national, regional, state, and local organizations 13. Bonica JJ: The Management of Pain. Philadelphia, Lea & devoted to pain and pain management are all having Febiger, 1953. 14. Rey R: Antiquity. In History of Pain. XIII. Paris, Editions la a significant impact on the dissemination of knowl- Decouverte, 1993, p 19. edge, promotion of research, and realization of net- 15. Keele KD: Anatomies of Pain. Oxford, Blackwell Science, working on local, national, and international levels. 1957. Pain practitioners and investigators are no longer 16. Schiff M: Lerbuch der Phusiologie der Muskel, und Nerven- isolated, and a flurry of published manuscripts physiologie, Schavenburg, Lahr, 1848. 17. Bliz M: Experimentelle Beitrag zur Lösung der Frage uber die and textbooks now cover a wide array of pain medi- spezifische Energie der Hautnerven. Z Biol 1884;20:141. cine topics. Credentialing is well on its way, and 18. Goldscheider A: Die spezifische Energie der Gefuhlsnerven der two credible organizations are responsible for creden- Haut. Monatsschrift Prakt Germatol 1884;3:282. tialing pain physicians in the United States. They 19. von Frey M: Ber Verhandl Konig Sachs Ges Wiss. Beitr Zur Physiol des Schmerzsinnes 1894;45:185. include the diploma offered by the ABPM and the 20. Mueller J: In Baly W (transl) Handbuch der Physiologie des Certificate of Added Qualification by the American Menschen. London, Taylor and Walton, 1840. Board of Anesthesiology. Diplomas are offered by 21. Darwin E: Zoonomia, or the Laws of Organic Life. London, examination. J Johnson, 1794. With the change in medical dynamics and the 22. Erb WH: Krankheitender peripherischen cerebrosphinalen Nerven. In Luckey G: Some recent studies of pain. Am J realities created by managed care and the different Psychol 1895;7:109. health maintenance organizations, pain medicine 23. Letievant E: Traites des Sections Nerveuses. Paris, JB Bailliere, has had to redirect its strategies for effective delivery 1873. and fair reimbursement for services rendered. Many 24. White JC, Sweet WH: Pain and the Neurosurgeon: A Forty-Year Experience. Springfield, Ill, Charles C Thomas, 1969. groups are dealing with these issues, and it is clear 25. Raj PP (ed): History of pain management. In Practical Manage- that the scientific community concerned with pain ment of Pain. Chicago, Year Book Medical Publishers, 1986, must develop reliable and reproducible outcome p 3. measures to maintain high quality and competence 26. Dogliotti AM: Traitement des syndromes douloureqx de la in the management of chronic pain. peripherie par alcoholisation sub-arachnoidienne. Presse Med 1931;39:1249. The training of pain specialists is being given 27. Leriche R: Surgery of Pain. Baltimore, William & Wilkins, serious consideration, and it is likely that in addition 1939. to the current 1-year pain medicine fellowships, 28. Bonica JJ (ed): Cancer pain. In The Management of Pain (3rd attempts will be made to establish residencies in pain ed.). Philadelphia, Lea & Febiger, 1990, p 400. 29. Melzack R, Wall PD: Pain mechanisms: A new theory. Science medicine. It is clear that, in addition to offering these 1965;150:971. postgraduate measures, the administrators of medical 30. Abram SE: Advances in chronic pain management since gate schools must reevaluate their educational programs control. Reg Anesth 1993;18:66. and must make their curricula more inclusive of pain 31. Turk DC, Okifuji A: Psychological factors in chronic pain: medicine. With such changes taking place, the future Evolution and revolution. J Consult Clin Psychol 2002;70: 678. of pain medicine looks bright as a result of the major 32. Head H, Holmes G: Sensory disturbances from cerebral lesions. contributions at all levels by dedicated and commit- Brain 1911;34:102. ted pain clinicians and researchers. 33. Marshall J: Sensory disturbances in cortical wounds with special reference to pain. J Neurol Neurosurg Psychiatry 1951; 14:187. References 34. Melzack R, Casey KL: Sensory, motivational and central control determinants of pain: A new conceptual model. In Kenshalo 1. Procacci P, Maresca M: Evolution of the concept of pain. In D (ed): The Skin Senses. Springfield, Ill, Charles C. Thomas, Sicuteri F (ed): Advances in Pain Research and Therapy, vol. 1968, pp 423-443. 20. New York, Raven Press, 1984, p 1. 35. Fordyce WE: Psychological factors in the failed back. Int 2. Raj PP: Pain relief: Fact or fancy? Reg Anesth 1990;15:157. Disabil Stud 1988;10:29. 3. Unruh AM: Voices from the past: Ancient views of pain in 36. Fordyce WE: Behavioural science and chronic pain. Postgradu- childhood. Clin J Pain 1992;8:247. ate Med J 1984;60:865. 4. Caton D: The secularization of pain. Anesthesiology 1985; 37. Fordyce WE: Behavioral factors in pain. Neurosurg Clin N Am 62:93. 1991;2:749. 5. Warfield C: A history of pain relief. Hosp Pract 1988;7:121. 38. Turk DC: Clinical effectiveness and cost-effectiveness of treat- 6. Jaros JA: The concept of pain. Crit Care Nurs Clin North Am ments for patients with chronic pain. Clin J Pain 2002; 1991;1:1. 18:355. 7. Procacci P, Maresca M: Pain concepts in Western civilization: 39. Turk DC: Chronic non-malignant pain patients and health A historical review. In Benedetti C (ed): Advances in Pain economic consequences. Eur J Pain 2002;6:353. Research and Therapy, vol. 7. Recent Advances in the Manage- 40. Craven J, Wald FS: Hospice case for dying patients. Am J Nurs ment of Pain. New York, Raven Press, 1984, p 1. 1993;75:1816. 8. Todd EM: Pain: Historical perspectives. In Aronoff GM (ed): 41. Allan N: Hospice to hospital in the near east: An instance of Evaluation and Treatment of Chronic Pain. Baltimore, Urban continuity and change in late antiquity. Bull Hist Med and Schwarzenberg, 1985, p 1. 1990;64:446. 9. Castiglioni A: A History of Medicine. New York, Alfred A 42. Campbell L: History of the hospice movement. Cancer Nurs Knopf, 1947. 1986;9:333. 10. Lin Y: The Wisdom of India. London, Joseph, 1949. 43. Saunders C: The last stages of life. Am J Nurs 1965;65:70.