Innovative Molecular Diagnostic Technologies and Emerging Markets
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  • 1. Innovative Molecular Diagnostic Technologies and EmergingMarketsReport Details:Published:November 2012No. of Pages: 1050Price: Single User License – US$23800 The report explores business and technological trends in the US, five major European countries,(France, Germany, Italy, Spain, UK) and Japan; provides 5- and 10-year test volume/salesforecasts; estimates shares of leading competitors; compares features of major analyzers; profilesleading market players; and identifies specific product and business opportunities facinginstrument and consumable suppliers during the next ten years. The molecular diagnostics marketis unquestionably the most rapidly growing segment of the in vitro diagnostics industry. The nextten years will witness significant developments in reagent systems and automation, as well asintroduction of a wide range of new products that will require innovative marketing approaches.The rate of market penetration into routine clinical laboratories, however, will depend on theintroduction of cost-effective and automated systems with amplification methods. In order tosuccessfully capitalize on the opportunities presented by the molecular diagnostics market, manycompanies are already exploiting new DNA probe and biochip technologies as corporate strategicassets, managed in support of business and marketing strategies. Integrating new technologyplanning with business and corporate strategies will be one of the most challenging tasks fordiagnostics companies during the next ten years.Get your copy of this report @http://www.reportsnreports.com/reports/205882-innovative-molecular-diagnostic-technologies-and-emerging-markets.htmlMajor points covered in Table of Contents of this report includeTable of ContentsIntroductionWorldwide Market And Technology OverviewA. DNA Sequencing1. Introduction2. Sequencing Methods
  • 2. 3. Autoradiography4. The Human Genome Project5. Sequencing Automation6. Image Scanners7. Fluorescent Detection8. Gene Profiling9. Gene Expression10. Polymorphism Screening11. Protein Interaction NetworksB. DNA And RNA Probe Technology1. Basic Principles2. Probe Preparation3. The DNA Probe Testa. Sample Preparationb. Hybridizationc. Separationd. Detection/Measurement4. Test Formatsa. Filter Hybridizationb. Southern Blotc. Northern Blotd. In Situ Hybridizatione. Others5. Labeling Techniques6. Amplification MethodsPolymerase Chain ReactionTemperature CyclersPCR VariationsImmuno-PCRQC-PCRDAP-PCRStrand Displacement ActivationTMALigase Chain ReactionBranched DNAHybridization Protection AssayNucleic-Acid Sequence-Based AmplificationSelf-Sustained Sequence ReplicaseOthersAmpliprobeCARCAS
  • 3. CPTDendritic Polymer TechnologyISO-CRLATProbe NetworksRAMPRepair Chain ReactionRolling CirclesSequence Independent Gene AmplificationSequence Initiation ReactionSISPASolid Phase AmplificationC. Detection Technologies1. Radioactive Methodsa. Overviewb. Major IsotopesP-32S-35H-3I-1252. Non-Isotopic Methodsa. Enzymatic Labelsb. Chemical LabelingIndirect Chemical LabelingDirect Chemical Labelingc. Fluorescenced. Chemiluminescencee. Electrical ConductivityD. Instrumentation Review1. Abbott LCx2. Beckman Coulter/Biomek FK3. Becton Dickinson SDA4. Bio-Rad GeneScope5. Gen-Probe Tigris6. Roche Cobas Amplicor7. Tecan LS SeriesE. Biochips: Genosensors, Microarrays, andLabs-on-the-ChipLiquid Transportation and MixingSeparationReactionDetection
  • 4. F. PharmacogenomicsG. Major Applications1. Microbiology/Infectious Diseasesa. Overviewb. Major Infectious DiseasesAIDSStructure and CompositionClassificationAIDS OriginsAnimal Lentivirus SystemsVirus ReceptorsHIV Infections in HumansPathogenesis and PathologyCD4T Lymphocytes and Memory CellsMonocytes and MacrophagesLymphoid OrgansNeural CellsViral CoinfectionsClinical FindingsPlasma Viral LoadPediatric AIDSNeurologic DiseaseOpportunistic InfectionsCancerImmunityVirus IsolationSerologyViral Nucleic Acid/Antigen DetectionEpidemiologyWorldwide Spread of AIDSUnited StatesRoutes of TransmissionDNA ProbesOverviewQuantitative PCRIn Situ PCRNeeded ImprovementsViral Load/Drug Resistance TestingGenotype and Phenotype TestingBlood Banking ConsiderationsAdenovirusBackground
  • 5. Diagnostic TestsVaccines and DrugsAdeno-Associated Viruses (AAV)Anthrax/Bacillus AnthracisBackgroundDiagnostic TestsVaccines and DrugsBabesiosisBackgroundBEA and Other Bartonella DiseasesBackgroundDiagnostic TestsVaccines and DrugsChagas DiseaseBackgroundCampylobacterBackgroundDiagnostic TestsCulture IdentificationVaccines and DrugsChlamydiaBackgroundChlamydia psittaciChlmaydia pneumoniaeChlamydia trachomatisDiagnostic TestsVaccines and DrugsCreutzfeldt-Jakob’s DiseaseBackgroundBlood TransmissionDiagnostic TestsMajor Commercial and Academic PlayersBayerDisease Sciences/BiTec GlobalImperial College School of MedicineOrtho-Clinical DiagnosticsPallProMetic Life SciencesProteome Sciences/IdexxQ-One BiotechSerono
  • 6. U.S. Agricultural Research ServiceDrugsVaccinesCytomegalovirusBackgroundChorioretinitisGastrointestinalCentral Nervous System DiseaseDiagnostic TestsVaccines and DrugsEbola VirusBackgroundEpidemiologyClinical SyndromesDiagnostic TestsVaccines and DrugsEchoVirusBackgroundAcute Aseptic MeningitisisEncephalitisExanthemsRespiratory DiseaseMyopericarditisNeonatal InfectionsDiagnostic TestsVaccines and DrugsEncephalitisBackgroundDiagnostic TestsVaccines and DrugsEnterovirusesBackgroundDiagnostic TestsViral Isolation and IdentificationAntibody TestsVaccines and DrugsEpstein-Barr VirusBackgroundDiagnostic TestsVaccines and DrugsGonorrheaBackground
  • 7. Diagnostic TestsVaccines and DrugsHepatitisHepatitis AHepatitis BStructure and CompositionReplicationHepatitis CHepatitis D (Delta)Hepatitis EHepatitis GHepatitis Infections PathologyClinical FindingsLaboratory TestsHepatitis AHepatitis BHepatitis CHepatitis DHepatitis EVirus-Host Immune ReactionsEpidemiologyHepatitis AHepatitis BHepatitis CHepatitis D (Delta)Vaccines and DrugsHerpes Simplex VirusBackgroundDiagnostic TestsVaccines and DrugsLegionellaBackgroundDiagnostic TestsVaccines and DrugsLyme DiseaseBackgroundClinical DescriptionClinical Case DefinitionLaboratory Criteria for DiagnosisCase ClassificationDiagnostic TestsVaccines and Drugs
  • 8. MalariaMycoplasmaBackgroundUreaplasma Urealyticum & MycoplasmaHominisDiagnostic TestsVaccines and DrugsPapillomaviruses/HPVBackgroundHPV in CancerCervical NeoplasmDiagnostic TestsVaccines and DrugsPreventionParvovirus B19BackgroundMicrobiologyEpidemiologyClinical SyndromesErythema Infectiosum (Slapped Cheek)Adult PolyarthropathyTransient Aplastic CrisisTransient PancytopeniaRed Cell Aplasia in ImmunocompromisedPerinatal InfectionsDiagnostic TestVaccines and DrugsPneumoniaBackgroundDiagnostic TestsVaccines and DrugsPolyomavirusesBackgroundDiagnostic TestsVaccines and DrugsSalmonellosisBackgroundDiagnostic TestsVaccines and DrugsShigellosisBackgroundDiagnostic Tests
  • 9. Vaccines and DrugsStreptococciBackgroundDiagnostic TestsVaccines and DrugsGroup A StreptococciGroup B StreptococciToxoplasmosisBackgroundDiagnostic TestsVaccines and DrugsTuberculosisBackgroundDiagnostic TestsMicroscopic CharacteristicsCultural CharacteristicsSkin TestsMDRTBVaccines and DrugsWest Nile VirusBackgroundClinical SyndromesDiagnostic TestsVaccines and DrugsYersiniaBackgroundDiagnostic TestsVaccines and Drugsc. Antibiotic Susceptibility2. Cancer Testinga. Overviewb. Major Cancer TypesProstateLungColon and RectumBreastSkinUterineLeukemiaOralc. OncogenesAbl/abl-bcr
  • 10. AIB1BCL-2BRCA1CD44C-fosC-mybC-mycCYP17Erb-BHPC1N-mycP40P51P53PIK3CAPTI-1RasRegSisSrc3. Genetic Diseasesa. Overviewb. Nucleic Acid Amplificationc. Chromosome Imagingd. Genomics Technologiese. Proteomics Technologiesf. Current Pharmacogenomic Testsg. Future Pharmacogenomic Testingh. Major DiseasesAchondroplasiaAutosomal Dominant Polycystic KidneyDiseaseCancerCosmetogenomicsCystic FibrosisDowns SyndromeDuchenne and Becker Muscular DystrophyFactor V (Leiden)Factor IX DeficiencyFragile X SyndromeHeart DiseaseHemochomatosis
  • 11. HemophiliaHuntingtons DiseaseMaternal-Fetal IncompatibilityMultiple Endocrine NeoplasiaPhenylketonuria (PKU)Polycystic Kidney Disease (PKD)Prenatal ScreeningRetinitis PigmentosaRetinoblastomaSickle Cell AnemiaSpinal Muscular AtrophyVitamin B12 Metabolismi. Social Issues and Concerns4. Forensic Testinga. Overviewb. Multilocus and Single Locus ProbesMultilocus ProbesSingle Locus ProbesPCR and RFLPc. The FBId. DNA Profile Data BanksU.S.A.U.K.e. Judicial Implementationf. Major Crime Categoriesg. Factors Contributing tthe DNA ProbeMarket ExpansionTechnology AvailabilityUse of Hair as Evidenceh. Wildlife Forensics5. Paternity Testing/HLA Typing6. Other Applicationsa. Disease Susceptibility Testingb. Cardiovascular Diseasesc. Diabetesd. Alzheimers Diseasee. Periodontal Diseasef. Plasma Purificationg. Organ Transplantationh. Water Contaminationi. OtherH. Competing/complementing Technologies
  • 12. 1. Monoclonal Antibodies/Immunoassays2. RNA Probes3. Two-Dimensional Electrophoresis4. Flow CytometryI. Worldwide Market Overview1. Business Environment2. Market Structure3. Market Size and GrowthFranceA. Executive SummaryB. Business EnvironmentC. Market StructureD. Market Size, Growth And Major Suppliers’Sales And Market SharesGermanyA. Executive SummaryB. Business EnvironmentC. Market StructureD. Market Size, Growth And Major Suppliers’Sales And Market SharesItalyA. Executive SummaryB. Business EnvironmentC. Market StructureD. Market Size, Growth And Major Suppliers’Sales And Market SharesJapanA. Executive SummaryB. Business EnvironmentC. Market StructureD. Market Size, Growth And Major Suppliers’Sales And Market SharesSpainA. Executive SummaryB. Business EnvironmentC. Market StructureD. Market Size, Growth And Major Suppliers’Sales And Market SharesU.K.A. Executive SummaryB. Business EnvironmentC. Market Structure
  • 13. D. Market Size, Growth And Major Suppliers’Sales And Market SharesU.S.A.A. Executive SummaryB. Business Environment1. Health Care Expenditures2. Cost Consciousness3. Reimbursement4. Industry Consolidation5. Managed Carea. PPOb. HMO6. Hospitals7. Admissions8. Length of Stay9. Industry Diversification10. Physician Demographics11. Population Aginga. Chronic Illnessb. Disease Incidencec. Susceptibility tIatrogenesisd. Multiple Illness Cases12. Laboratory Regulations13. FDA ReformC. Market Structure1. Hospitals2. Commercial/Private Laboratories3. Blood BanksD. Market Size, Growth and Major Suppliers’Sales and Market SharesMajor Product Development OpportunitiesA. InstrumentationB. Reagent Kits and Test Systems/panelsC. Computers, Software and AutomationD. Auxiliary ProductsDesign Criteria For Decentralized Testing ProductsAlternative Market Penetration StrategiesA. Internal DevelopmentB. Collaborative ArrangementsC. University ContractsD. Distribution Strategies For Decentralized TestingMarkets
  • 14. 1. Marketing Approaches2. Product Complexity3. Customer Preference4. Established Suppliers5. Emerging Suppliers6. Major Types Of Distributors7. Market SegmentationPotential Market Entry Barriers And RisksA. Market MaturityB. Cost ContainmentC. CompetitionD. Technological Edge And LimitationsE. Patent ProtectionF. Regulatory ConstraintsG. Decentralized Testing Market ChallengesCompetitive ProfilesAbbottAffymetrixAgilentApplied Gene TechnologiesArcaBeckman Coulter/DanaherBecton DickinsonBiokitBioMerieuxBio-RadBiotestCaliperCepheidDecodeDiadexusEikenEnzoExact SciencesFujirebioGen-ProbeHologicIlluminaInnogenetics/SolvayKreatechLi-Cor BiosciencesLife Technologies
  • 15. Monogram BiosciencesMyriad GeneticsNanogen/ElitechNovartisOrchid CellMarkOrtho-Clinical DiagnosticsProteome SciencesQiagenRocheScienionSequenomShimadzuSiemensSierra MolecularTakara BioTecan GroupAppendixesAppendix I: Major Universities and Research CentersDeveloping Molecular DiagnosticTechnologyAppendix II: Glossary of TermsAppendix III: Currency Exchange RatesList of TablesMajor Companies Developing or Marketing AIDS MolecularDiagnostic And Other Direct Identification TestsMajor Companies Developing or Marketing AdenovirusMolecular Diagnostic And Other DirectIdentification TestsMajor Companies Developing or Marketing CampylobacterMolecular Diagnostic And Other DirectIdentification TestsMajor Companies Developing or Marketing ChlamydiaMolecular Diagnostic And Other DirectIdentification TestsMajor Companies Developing or Marketing CMV MolecularDiagnostic And Other Direct Identification TestsMajor Companies Developing or Marketing EBV MolecularDiagnostic And Other Direct Identification TestsMajor Companies Developing or Marketing GonorrheaMolecular Diagnostic And Other Direct
  • 16. Identification TestsMajor Companies Developing or Marketing HepatitisMolecular Diagnostic And Other DirectIdentification TestsMajor Companies Developing or Marketing HerpesMolecular Diagnostic And Other DirectIdentification TestsMajor Companies Developing or Marketing LegionellaMolecular Diagnostic And Other DirectIdentification TestsMajor Companies Developing or Marketing LymeDisease Molecular Diagnostic And Other DirectIdentification TestsMajor Companies Developing or Marketing MycoplasmaMolecular Diagnostic And Other DirectIdentification TestsMajor Companies Developing or Marketing PapillomaVirus Molecular Diagnostic And Other DirectIdentification TestsMajor Companies Developing or Marketing PneumoniaMolecular Diagnostic And Other DirectIdentification TestsMajor Companies Developing or Marketing SalmonellaMolecular Diagnostic And Other DirectIdentification TestsMajor Companies Developing or Marketing ShigellaMolecular Diagnostic And Other DirectIdentification TestsMajor Companies Developing or Marketing StreptococciMolecular Diagnostic And Other DirectIdentification TestsMajor Companies Developing or Marketing ToxoplasmosisMolecular Diagnostic And Other DirectIdentification TestsMajor Companies Developing or Marketing TuberculosisMolecular Diagnostic And Other DirectIdentification TestsOncogenes Potential Application in Cancer DiagnosisMajor Companies Developing or Marketing CancerMolecular Diagnostic TestsMajor Companies Developing or Marketing MolecularDiagnostic Test For Genetic Diseases
  • 17. Worldwide, Laboratories Performing DNA SequencingBy CountryWorldwide, Molecular Diagnostics Market PotentialLaboratory Universe by CountryWorldwide, Molecular Diagnostic Test Volume ForecastBy CountryWorldwide, Molecular Diagnostics MarketForecast by CountrySummary Table France, Molecular Diagnostic Test VolumeAnd Sales Forecast by Major ApplicationFrance, Laboratories Performing DNA SequencingBy Market SegmentFrance, Molecular Diagnostics Market PotentialLaboratory Universe by Market SegmentFrance, Molecular Diagnostic Test Volume ForecastBy Major ApplicationFrance, Major Infectious Disease MolecularDiagnostics Test Volume ForecastFrance, Infectious Disease ScreeningNAT Volume ForecastFrance, Molecular Diagnostics Market ForecastBy Major ApplicationFrance, Infectious Disease Screening NAT ReagentMarket Forecast by TestFrance, Molecular Diagnostics MarketBy Major SupplierFrance, HIV/Hepatitis NAT Market Reagent SalesBy Major SupplierSummary Table Germany, Molecular Diagnostics Test VolumeAnd Sales Forecast by Major ApplicationGermany, Laboratories PerformingDNA Sequencing by Market SegmentGermany, Molecular Diagnostics MarketPotential Laboratory Universe by Market SegmentGermany, Molecular Diagnostics Test Volume ForecastBy Major ApplicationGermany, Major Infectious Disease MolecularDiagnostics Test Volume ForecastGermany, Infectious Disease ScreeningNAT Volume ForecastGermany, Molecular Diagnostics Market ForecastBy Major Application
  • 18. Germany, Infectious Disease ScreeningNAT Reagent Market Forecast by TestGermany, Molecular DiagnosticsMarket by Major SupplierGermany, HIV/Hepatitis NAT Market ReagentSales by Major SupplierSummary Table Italy, Molecular Diagnostics Test VolumeAnd Sales Forecast by Major ApplicationItaly, Laboratories PerformingDNA Sequencing by Market SegmentItaly, Molecular Diagnostics Market PotentialLaboratory Universe by Market SegmentItaly, Molecular Diagnostics Test Volume ForecastBy Major ApplicationItaly, Major Infectious Disease MolecularDiagnostics Test Volume ForecastItaly, Infectious Disease ScreeningNAT Volume ForecastItaly, Molecular Diagnostics Market ForecastBy Major ApplicationItaly, Infectious Disease ScreeningNat Reagent Market Forecast by TestItaly, Molecular Diagnostics MarketBy Major SupplierItaly, HIV/Hepatitis NAT MarketBy Major SupplierSummary Table Japan, Molecular Diagnostics Test VolumeAnd Sales Forecast by Major ApplicationJapan, Laboratories PerformingDNA Sequencing by Market SegmentJapan, Molecular Diagnostics Market PotentialLaboratory Universe by Market SegmentJapan, Molecular Diagnostics Test Volume ForecastBy Major ApplicationJapan, Major Infectious Disease MolecularDiagnostics Test Volume ForecastJapan, Infectious Disease ScreeningNAT Volume ForecastJapan, Molecular Diagnostics Market ForecastBy Major ApplicationJapan, Infectious Disease Screening Nat ReagentMarket Forecast by Test
  • 19. Japan, Molecular Diagnostics MarketBy Major SupplierJapan, HIV/Hepatitis NAT MarketReagent Sales by Major SupplierSummary Table Spain, Molecular Diagnostics Test VolumeAnd Sales Forecast by Major ApplicationSpain, Laboratories PerformingDNA Sequencing by Market SegmentSpain, Molecular Diagnostics Market, PotentialLaboratory Universe by Market SegmentSpain, Molecular Diagnostics Test VolumeForecast by Major ApplicationSpain, Major Infectious Disease MolecularDiagnostics Test Volume ForecastSpain, Infectious Disease ScreeningNAT Volume ForecastSpain, Molecular Diagnostics Market ForecastBy Major ApplicationSpain, Infectious Disease Screening NatReagent Market Forecast by TestSpain, Molecular Diagnostics MarketBy Major SupplierSpain, HIV/Hepatitis NAT Market ReagentSales by Major SupplierSummary Table U.K., Molecular Diagnostics Test VolumeAnd Sales Forecast by Major ApplicationU.K., Laboratories PerformingDna Sequencing by Market SegmentU.K., Molecular Diagnostics Market PotentialLaboratory Universe by Market SegmentU.K., Molecular Diagnostics Test Volume ForecastBy Major ApplicationU.K., Major Infectious Disease MolecularDiagnostics Test Volume ForecastU.K., Infectious Disease ScreeningNAT Volume ForecastU.K., Molecular Diagnostics Market ForecastBy Major ApplicationU.K., Infectious Disease Screening NAT ReagentMarket Forecast by TestU.K., Molecular Diagnostics Market by Major SupplierSummary Table U.S.A., Molecular Diagnostics Test Volume
  • 20. And Sales Forecast by Major ApplicationU.S.A., Laboratories PerformingDNA Sequencing by Market SegmentU.S.A., Molecular Diagnostics Market, PotentialLaboratory Universe by Market SegmentU.S.A., Molecular Diagnostics Test Volume ForecastBy Major ApplicationU.S.A., Major Infectious Disease MolecularDiagnostics Test Volume ForecastU.S.A., Infectious Disease ScreeningNAT Volume by Test ForecastU.S.A., Molecular Diagnostics Market ForecastBy Major ApplicationU.S.A., Infectious Disease Screening Nat ReagentMarket Forecast by TestU.S.A., Molecular Diagnostics Market by Major SupplierU.S.A., HIV/Hepatitis C NAT Market Reagent SalesBy Major SupplierU.S.A., West Nile Virus NAT Market Reagent SalesBy Major SupplierContact: sales@reportsandreports.com for more information.