1. Reid Rubsamen
HIV/TB CLINICAL RESEARCH
DURBAN

2. PheZulu Safari Park
Zulu Hut Zulu Tribe Performers

3. Caprisa Research and Treatment Clinic
Parallel work on TB and HIV

4. Tour Guides
Ayesha Kharsany
Lulu Nair

5. Caprisa Clinic Intake Waiting Room
All charts are electronic

6. On the Roof
N95 respirator required for clinic tour

7. Neighborhood Across the Street
Ambulance driver training school

8. Caprisa Clinic Placards
Education Facility Safety

9. Sample Collection
TB screening is primarily via sputum collection. PPD not useful in patients over five years
old because of prevalence of BCG vaccination.

10. Counseling Area
Lay counselors enroll patients in VOICE trial.

11. Counseling Session For VOICE Trial
Vaginal gel with anti-viral agents. >30% signal in 600 patient Phase IIb with peri-coital
administration. Sponsor wants daily dosing in Phase III. Quintiles is overseeing the Phase
III study for Conrad Pharmaceuticals.

12. Study Registration
Fingerprint scanner eliminates possibility of co-enrollment (which was a problem with the
VOICE Phase IIb trial).

13. Fingerprint Acquisition
Fingerprint Scanner Reid’s Thumbprint

14. Clinic-Based Data Management
Data-FAX system used.
All HPP data sent to
SHARP
Clinic has read-only
access to OCR
translated CRFs for QC
Fingerprint scanner
eliminates possibility of
unauthorized co-
enrollment

15. Clinical Trial Management
Audits by NIH and Quintiles

16. Caprisa Clinic
Operations Infrastructure Clinic Video

17. The Medical School
Main Entrance

18. Medical School Neighborhood
Looking East Looking West

19. Medical School Facility - HHMRI
Howard Hughes Medical Research Institute under construction. P3 lab will be included for
TB research.

20. Medical School Facility Focus
HIV and TB
Facility Directory Detail

21. Medical School Facility
Caprisa Offices

22. Medical School Facility
Reid and Salim Abdool Karim Slim’s Office Entrance

23. Medical School Facility
News clipping display Bruce walker detail

24. Medical School Facility
Bruce walker Lab corridor

25. HIV Pathogenesis Programme
HPP Entity Poster HPP Process Outline

26. Flow Cytometry
Clinical FACS 4 wavelength FACS machine
Expanded wavelength research FACS in same facility

27. All Positive Samples Frozen

28. Medical School Facility

29. Parallel TB Research
Study in-progress is
evaluating the optimal
timing of co-delivery of
anti infective and anti
viral agents in patients
infected with HIV and
TB

30. HPP Enabled Studies
Systematic tracking of patient cohorts in various HIV infection states allows for wide range
of hypothesis testing