Strategy for Open Innovation in
Sigma Life Science




                               • Rebecca Poon, PhD, MBA
           ...
The Strength of Sigma-Aldrich

• Leading supplier in the life science research
  market

• Known for quality, reliability,...
Sigma-Aldrich Portfolio

             Large                                      Broad
         Product Breadth           ...
World Class Distribution & Logistics
 • Sell into 160 countries from locations in 38 countries
 • 38 production sites in 1...
Sigma-Aldrich Brands
Creating Differentiation Through
Innovation: 2009 - 2011
• Accelerate
  • Build on Successes

  • Focus on Research Biotec...
Business Units and Revenues

                      ($421M)
                         19%
                                  ...
Sigma Life Science Vision


To be a leading destination for life science researchers
 to access biologically rich informat...
Sigma Life Science’s Practice in
Open Innovation
• Patent Licenses, Option licenses, Cross-Licenses (Many)
• Research Coll...
Business Development
Statistics & Philosophy
• Active Licenses: 490
• Oldest Dated: 1983
• No of New Licenses (2007): 28
•...
Case Study 1
TRC -- The Broad Institute

 • 11 world-renowned academic and
   international life sciences companies

 • Ex...
Case Study 2
Human Proteome Resource (HPR)

• Royal Institute of Technology (KTH),

 Stockholm, The Rudbeck Laboratory, an...
Case Study 3
Sangamo Biosciences, Inc.
• Large portfolio of enabling technologies
 aggregated from many institutions

• Zi...
Continuing Outreach Activities


• Campus visits to Office of Technology Licensing


• Sigma Partnering Event (hosted by a...
Strategic Areas in Technology
Scouting
Technology Areas                                Research Areas
• Biomolecules      ...
•Rebecca Poon, PhD, MBA
•Business Development Manager
•314-286-7859
•rebecca.poon@sial.com
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Open Innovation Strategy in Sigma Life Sciences_NCET2 Webinar Oct 09

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Use of open innovation to complement internal R&D function for bandwidth, increased efficiency and risk management with the goal of maintaining leadership in product and technology. Case studies in a life science company.

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Open Innovation Strategy in Sigma Life Sciences_NCET2 Webinar Oct 09

  1. 1. Strategy for Open Innovation in Sigma Life Science • Rebecca Poon, PhD, MBA • Business Development Manager • NCET2 Webinar • Making the Most of U-I Collaborations • 314-286-7859 • rebecca.poon@sial.com
  2. 2. The Strength of Sigma-Aldrich • Leading supplier in the life science research market • Known for quality, reliability, consistency • World-leading customer & technical service • Manufacture over 46,000 products • 1,000,000 customers • 7,900 employees • 2008 Sales: $2.2B • 34 years of continuous growth (Sales & EPS)
  3. 3. Sigma-Aldrich Portfolio Large Broad Product Breadth Customer Base Products – 130,000 Customers – 88,000 accounts Number of products 8% 30,000 35% 26% 31% Chemicals 100,000 Pharmaceutical, Diagnostics, Biotechnology Companies Equipment items (46,000 Chemical & Allied Industrial Companies manufactured) Universities, Government, Not-for-Profit Organizations Hospitals & Commercial Laboratories
  4. 4. World Class Distribution & Logistics • Sell into 160 countries from locations in 38 countries • 38 production sites in 10 countries • Over 15,000 orders received & shipped daily • Global distribution network Service is key
  5. 5. Sigma-Aldrich Brands
  6. 6. Creating Differentiation Through Innovation: 2009 - 2011 • Accelerate • Build on Successes • Focus on Research Biotech • Expand in Faster Growing Geographies • Elevate • Enable Web Strategies: Your Favorite Gene (2009 CIO 100 winner) • Refine Selection & Integration of New Technologies • Innovate • New Ventures Group • SAGE™ Lab
  7. 7. Business Units and Revenues ($421M) 19% 38% ($824M) 28% ($624M) 15% ($332M) Research Specialities Researach Biotech SAFC Research Essentials Research Biotech Customers: Life Scientists Driving Force: Innovation
  8. 8. Sigma Life Science Vision To be a leading destination for life science researchers to access biologically rich information, market leading products and services to help answer their biological questions Lead with Breakthrough Products Supported by Rich Biological Information
  9. 9. Sigma Life Science’s Practice in Open Innovation • Patent Licenses, Option licenses, Cross-Licenses (Many) • Research Collaborations: • Odyssey Program: UVA, NIH, U Chicago, Wash U • Others: Mayo clinic, UNC, UCSD, Fred Hutchinson, U Pittsburgh, UCSF, Columbia • Joint Grant Application (Boston U, Framingham Heart Study, SABre-CVD) • Co-development Agreements • Equity Investment • M&A for Capabilities and Capacity • Alliance with Venture Firms (Prolog Ventures) • Outreach to Consortia (e.g. Protein Quantitation Consortium, Biomarkers, Nanotechnology) • Consultancy / Scientific Advisory Boards (e.g. Stem Cell, Regulatory ncRNA) • University Technology Subscription Program (WARF)
  10. 10. Business Development Statistics & Philosophy • Active Licenses: 490 • Oldest Dated: 1983 • No of New Licenses (2007): 28 • Total License Related Payments (2008): $12.13 M • Product Royalties (2008): $3.4M Equitable risk sharing: • Reward on performance • Milestone payments linked to realized technical and market performance • Royalties based on sales revenue, fixed or tiered Flexibility to meet partners’ different interests: • Options • Carve-outs of IP rights, freedom–to-operate, markets / fields of application
  11. 11. Case Study 1 TRC -- The Broad Institute • 11 world-renowned academic and international life sciences companies • Exclusive license & partnership in functional validation • shRNA library: TRCII – 300,000 clones • Lentivirus particles • Plasmids • Bacterial glycerol stock
  12. 12. Case Study 2 Human Proteome Resource (HPR) • Royal Institute of Technology (KTH), Stockholm, The Rudbeck Laboratory, and Uppsala University, Sweden • Goal: min. one antibody tool to each of 22,000 unique human proteins by 2015 • Exclusive license with Atlas Antibodies • Added over 6,000 antibodies • Most highly characterized, monospecific • Supported by IHC image data (on tissue microarrays) in Human Protein Atlas (HPA)
  13. 13. Case Study 3 Sangamo Biosciences, Inc. • Large portfolio of enabling technologies aggregated from many institutions • Zinc Finger Nuclease License 2007 • CompoZr™ (www.compozrzfn.com/) • Milestone reached 1 year early (Jan 09) • SAGE™ Lab: 12 members, new facility (Aug 21, 09) • SAGEspeed™ (www.sageresearchmodels.com) • Michael J Fox Foundation Award Parkinson Disease Models (Oct 1, 09)
  14. 14. Continuing Outreach Activities • Campus visits to Office of Technology Licensing • Sigma Partnering Event (hosted by a local organization) • Sigma Inventor’s Forum (Webinar) • Networking through UIDP (University-Industry Demonstration Partnership) • Participation in AUTM, LES, BIO conferences • Response to RFPs and fedbizopps.gov
  15. 15. Strategic Areas in Technology Scouting Technology Areas Research Areas • Biomolecules • Stem Cell Biology • Functional Genomics • Epigenetics • Cell Based Assays • Regenerative Medicine • Protein Assays • Oncology • Transgenics • Neuroscience • Cell Signaling • Inflammation Continuously Expand Technology Portfolio to further basic research and the understanding of biology
  16. 16. •Rebecca Poon, PhD, MBA •Business Development Manager •314-286-7859 •rebecca.poon@sial.com

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