Viral infections of Oral Cavity
Upcoming SlideShare
Loading in...5
×
 

Like this? Share it with your network

Share

Viral infections of Oral Cavity

on

  • 1,251 views

A presentation of around sixty slides giving an overview of general viral infections that can occur in oral cavity...

A presentation of around sixty slides giving an overview of general viral infections that can occur in oral cavity...

Statistics

Views

Total Views
1,251
Views on SlideShare
1,251
Embed Views
0

Actions

Likes
3
Downloads
85
Comments
0

0 Embeds 0

No embeds

Accessibility

Categories

Upload Details

Uploaded via as Microsoft PowerPoint

Usage Rights

© All Rights Reserved

Report content

Flagged as inappropriate Flag as inappropriate
Flag as inappropriate

Select your reason for flagging this presentation as inappropriate.

Cancel
  • Full Name Full Name Comment goes here.
    Are you sure you want to
    Your message goes here
    Processing…
Post Comment
Edit your comment

Viral infections of Oral Cavity Presentation Transcript

  • 1. Viral Infections... Dr Ravikumar V, JR II, Dept Of Oral Path, GDC, Kottayam
  • 2. Intro  What is a Virus..?  Basic structure  Sequlae of infection  Classification
  • 3. Herpes Simplex  HSV I and II  Skin, mucosa, eye and CNS
  • 4.  Herpes genitalis  Herpes meningoencephalitis  Herpetic conjunctivitis
  • 5.  Herpetic eczema  Disseminated HS of newborn  Herpetic whitlow  Herpes gladiatorum
  • 6. Primary Herpetic Stomatitis  Infancy and adult  Spread – droplets, contact  Fever, irritation, headache, pain on swallowing, regional lymphadenopathy  Yellow fluid filled vesicles which rupture to form characteristic ulcers
  • 7. Vesicles Erythematous halo Shallow Ulcer with Gray membrane
  • 8.  HSV culture from sites  HSV DNA demonstration in lumbar and trigeminal ganglia  Histology – ballooning degeneration - Lip schutz bodies Diagnosis – clinical, stains, cytology, DNA, PCR Treatment – Antiviral drugs, NSAID
  • 9. Reccurent Herpes Labialis / Stomatitis  Attenuated form of primary disease  Reactivation – ganglion trigger, skin trigger, emotional theory  The viruses spread through nerves and act on epithelial cells and cause inflammation
  • 10.  Lesions may recur at any interval  May occur on lips, intraoral, or along area of distribution of nerve  Preceded by tingling or burning sensation
  • 11.  Vesicles less than a mm appear as clusters which coalasce  Associated pain  Lesions heal by a week
  • 12. Diagnosis  Histology  Viral identification and isolation  Immunofluorescent tests  Immunoperoxide test  RIA and ELISA  Treatment
  • 13. Herpangina  Coxsakie group A virus  Ingestion, contact, droplet  Seen in summer, in young  Symptoms – sore throat, cough, rhinorhea, fever, vomiting and even abdominal pain  Vesicles which rupture to form ulcers  All of these heal by 7 days
  • 14.  No treatment needed as it is self limiting
  • 15. Hand Foot and Mouth Disease  Coxsakie and entero virus  Multiple ulcers with dysphagia  Intracytoplasmic viral inclusions, high antibody titer to Coxsakie  Self limiting
  • 16. RUBEOLA (MEASLES)  produced by a paramyxovirus  Affected individuals are infectious from 2 days before becoming symptomatic until 4 days after appearance of the rash  Incubation period of 8 to 12 days
  • 17.  Pre erutive, eruptive and post eruptive stage  Small red macules or papules appear which enlarge and coalesce to form irregular lesions which blanch on pressure and gradually fade in 4 or 5 days.  Koplik’s Spots  Warthin Finkeldey giant cells
  • 18. RUBELLA (GERMAN MEASLES)  capacity to induce birth defects  Forchheimer spots- small discrete dark-red papules that develop on the soft palate and may extend onto the hard palate
  • 19.  The classic triad of CRS consists of deafness, heart disease, and cataracts
  • 20. Molluscum Contagiosum  Caused by virus of pox group  Considered tumor like  Occur as single or multiple discrete elevated nodules with central crustation  Cowdry A inclusion bodies  Henderson Paterson inclusions
  • 21. Varicella
  • 22.  Oral lesions
  • 23. Herpes Zoster  James Ramsay Hunt’s syndrome
  • 24.  Tzank smear
  • 25. Mumps
  • 26. Non Specific Mumps  C/c Non Specific Sialadenitis  Acute Post operative Parotitis  Nutritional Mumps  Chemical Mumps  Miscellaneous
  • 27.  Human Immuno Deficiency Virus  Etiologic agent of Acquired Immunodeficiency Syndrome (AIDS).  Characterized by severe depletion of CD4 cells.
  • 28. MODES OF TRANSMISSION  Sexual transmission  Blood or blood products  Maternal-fetal  Infected needles
  • 29.  Transmission routes 
  • 30. CLASSIFICATION OF CLINICAL MANIFESTATIONS  Group I : Acute Infection  Group II : Chronic Asymptomatic Infections  Group III : Persistent Generalized Lymphadenopathy  Group IV : Aids Related Complex
  • 31. CHRONIC ASYMPTOMATIC INFECTIONS  Most dangerous group  Seropositive pt who is apparently healthy capable of infection  Enlarged axillary glands  Hematological & immunological abnormalities
  • 32. PERSISTENT GENERALISED LYMPHADENOPATHY  LYMPHADENOPATHY in 2 or more extrainguinal sites persisting for more than 3 months
  • 33. AIDS RELATED COMPLEX  OPPORTUNISTIC INFECTIONS -Pneumonia, Cryptococcosis, Viral Infections, Toxoplasmosis, TB etc.  NEOPLASMS - KS, Lymphoma, SCC
  • 34.  NEUROLOGIC DISEASES - Meningocephalitis  OTHERS - Encephalopathy, Purpura, Thrombocytopenia
  • 35.  Oral lesions in HIV...
  • 36. Candidiasis PSEUDOMEMBRANOUS ERYTHEMATOUS ANGULAR CHEILITIS
  • 37. HISTOPLASMOSIS  Histoplasma capsulatum Nodules over the mucosa which undergoes ulceration Gingiva, tongue, palate, buccal mucosa
  • 38. LINEAR GINGIVAL ERYTHMA Very fine red band along gingival margin and attached gingiva with profuse bleedin
  • 39. NECROTIZING ULCERATIVE PERIODONTITIS Advanced destruction of peridontium, rapid bone loss, loss of PDL
  • 40. Oral Hairy Leukoplakia
  • 41. WART (HPV)1 Painless papule or nodule with papillary projections or rough surface Pedunculated or Sessile
  • 42. APHTHOUS ULCER (MINOR) Single or multiple recurrent ulcers with whitish pseudomembrane & surrounded b Erythamatous halo mostly seen on cheek, tongue, soft palate, tonsils.
  • 43. APHTHOUS ULCER (MAJOR)
  • 44. KAPOSI’S SARCOMA  Predominantly in homosexuals.  lesions are vascular, angiomatous neoplasms that begin as red macule & progress to large tumefactive red & purple lesions.  Oral lesions: multifocal & typically seen on palate & gingiva
  • 45. LYMPHOMA  Most are of B cell origin and Epstein-Barr virus occurs in cells from several cases.  Lymphoma can occur anywhere in the oral cavity & there may be soft tissue involvement with or without involvement of underlying bone.
  • 46. Diagnosis of HIV  Viral Culture  PCR  P24 antigen detection  ELISA  Western Blot Treatment - HAART
  • 47. TREATMENT  Haart - zidovudine, stavudine, lamivudine, didanosine  Symptomatic treatment  Precautions
  • 48. Thank u...