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Polyneuropathy

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  • 1. Peripheral Neuropathy
  • 2. Peripheral Neuropathy DEFINITION:It is inflammation and degeneration of the peripheral nerves and/or the cranial nerves resulting in impairment of the conductivity of these nerves
  • 3. Classification of Neuropathy1- Mononeuropathy:2- Mononeuropathy multiplex:3- Polyneuropathy:
  • 4.  CAUSES OF MONONEUROPATHY:1- Trauma: wrong injection into a nerve, callus compression.2- Infective: leprosy, herpes zoster.3- Vascular: polyarteritis nodosa.4- Metabolic: diabetes mellilus.
  • 5. CAUSES OF POLYNEUROPATHYI-Heridofamilial:1- Hypertrophic interstitial polyneuropathy.2- Peroneal muscle atrophy.3- Refsums disease.
  • 6. Clinical Picture of polyneuropathyA- Motor:
  • 7. B- Sensory:
  • 8. GloveHypothesia Stock
  • 9. C-Autonomic: Vasomotor: coldness and cyanosis of the limbs. Cutaneous: loss of hair, brittle nails, trophic ulcers.
  • 10. Specific Types of PolyneuropathyI- PERONEAL MUSCLE ATROPHY
  • 11. Peroneal muscle AtrophyInverted Champagne-bottle appearance
  • 12. Diabetic Neuropathy Pathogenesis: Diabetic microangiopathy of the vasa nervosa. Ischaemia of the nerves, 2ry to atherosclerosis of the vasa nervosa.
  • 13. Treatment of Diabetic Neuropathy Proper management of diabetes: diet, oral hypoglycaemic drugs or insulin. VilaminsB1 100 mg daily, B6 200 mg daily, B12 1000 mg daily.
  • 14. Acute Infective Polyneuropathy Landary-Guillan-Barre Syndrome  Aetiology:It is due to an allergic or auto-immune reaction secondary to a previous non- specific virus infection.
  • 15. Clinical Picture1-Febrile stage:2-Latent stage:
  • 16. 3-Paralytic stage:
  • 17. PN Testing fordiagnosis The EMG test itself:  Nerve Conduction Studies (NCS)  EMG (Needle portion)
  • 18. Treatment of Guillain Barre Syndrome
  • 19. Thank you