• Share
  • Email
  • Embed
  • Like
  • Save
  • Private Content
Valvular heart disease
 

Valvular heart disease

on

  • 3,585 views

 

Statistics

Views

Total Views
3,585
Views on SlideShare
3,583
Embed Views
2

Actions

Likes
2
Downloads
211
Comments
1

2 Embeds 2

http://freelivedoctor.com 1
http://www.slideshare.net 1

Accessibility

Categories

Upload Details

Uploaded via as Microsoft PowerPoint

Usage Rights

© All Rights Reserved

Report content

Flagged as inappropriate Flag as inappropriate
Flag as inappropriate

Select your reason for flagging this presentation as inappropriate.

Cancel

11 of 1 previous next

  • Full Name Full Name Comment goes here.
    Are you sure you want to
    Your message goes here
    Processing…
  • Thank you for sharing your valuable information.this information very useful for online learners

    heart valvular disease
    Are you sure you want to
    Your message goes here
    Processing…
Post Comment
Edit your comment

    Valvular heart disease Valvular heart disease Presentation Transcript

      • VALVULAR HEART DISEASE
      • Causes
      • a) stenosis
      • i) “narrowing” and failure of forward flow
      • b) insufficiency (regurgitation, incompetence)
      • i) failure of valve to close completely
      • - allowing reverse flow
      www.freelivedoctor.com
    • www.freelivedoctor.com
    • www.freelivedoctor.com
    • www.freelivedoctor.com
    • c) Pure i) stenosis or regurgitation d) mixed i) stenosis and regurgitation coexist in same valve - usually 1 defect predominates e) isolated i) 1 valve f) combined i) more than 1 valve dysfunctional www.freelivedoctor.com
    • g) flow anomalies through valves produce turbulent flow patterns i) murmurs h) acquired valvular heart disease **ii) students should be able to match various heart valve diseases with both the specific valve involved and whether the disease is a stenosis, regurgitation or both www.freelivedoctor.com
    • iii) most frequent causes: - AS  calcification of congenitally deformed valve - AI  dilation of ascending aorta (e.g., hypertension and aging) - MS  RHD - MI  mitral valve prolapse (myxomatous degeneration) www.freelivedoctor.com
      • Calcification
      • valves subjected to  repetitive
      • stresses
      • a) at hinge points of cusps and leaflets
      • i) 75 bpm x 60 mins = 4500 bph
      • ii) 4500 bph x 24 hrs = 108,000 bpd
      • iii) 108,000 bpd x 365 days = ~40 million bpy
      • iv) 40 million bpy x 75 yrs = 3 billion bp your life !
      www.freelivedoctor.com
    • b) deformations during each beat c) pressures on valves in closed phase i) 120 mmHg  mitral valve ii) 80 mmHg  aortic valve d) the factors listed above (a,b,c) contribute to valvular damage seen by calcium deposits (Calcium Phosphate) i) 1 0 dystrophic calcification (different from atherosclerosis) - calcific AS - mitral annular calcification www.freelivedoctor.com
      • Calcific Aortic Stenosis
      • a) most common of all valvular abnormalities
      • i) geriatric (“wear and tear”)
      • of normal valve or congenital bicuspid aortic valve
      • b) incidence  due to  age
      • c)  incidence of RF in No. America
      • i) < 10% of acquired stenosis
      • d) 6-7 th decades (bicuspid valve)
      • e) 8-9 th decades (normal valve)
      • i) “senile calcific aortic stenosis”
      www.freelivedoctor.com
    • f) Clinical: i) LV outflow obstruction - LV compensates by  LVP to ~ 200 Hg  develops - LV concentric hypertrophy (pressure overload !!): CHF - ischemic myocardium  - angina may appear - systolic and diastolic impairment (e.g., syncope) ii) the S & S above indicate decompensation (poor progno.) www.freelivedoctor.com
      • g) 50% die within 5 yrs with angina
      • h ) 50% die within 2 years with CHF
      • i) patients w/out symptoms have excellent outcome
      • i) symptoms are critical factors
      • in management and outcome !!
      • Calcific stenosis of Congenitally
      • Bicuspid Aortic Valve
      • a) frequency ~ 1.5% live births
      • b) NOT symptomatic at birth or
      • through early life
      • c) 2 leaflets. 1 is larger
      www.freelivedoctor.com
    • i) larger leaflet increases calcification ii) once stenosis occurs, progression is similar to normal aortic valve d) bicuspid aortic valves may be acquired (RHD)  fused leaflets e) other causes of bicuspid aortic valve incompetence i) aortic dilation ii) cusp prolapse iii) infective endocarditis www.freelivedoctor.com
    • A . Acquired bicuspid aortic valve with secondary calcification. At the center of the conjoined cusp (lower center) are elements of two preexisting cusps, now fused. B. Congenital bicuspid valve. The characteristic raphe of the congenital bicuspid aortic valve appears at the lower portion of the figure. C. Senile type. None of the commissures is fused, but there is a major intrinsic calcification of the three cusps. D. Unicuspid, unicommissural congenital aortic stenosis with secondary calcification. A B C D www.freelivedoctor.com
    • Calcific aortic stenosis occurring on a congenitally bicuspid valve. One cusp has a partial fusion at its center, called a raphe (arrow). www.freelivedoctor.com
      • Mitral Annular Calcification
      • a) calcific nodules arounf fibrous annular ring of mitral valve
      • b) usually does not affect valvular function
      • i) rare cases:
      • - stenosis
      • - regurgitation
      • - sudden death (Ca ++ dependent)
      • - thrombus formation (stroke) and infections
      www.freelivedoctor.com
    • www.freelivedoctor.com
      • c) women > 60 yrs,  LVP, mitral valve prolapse, hypertrophic cardiomyopathy
      • Myxomatous Degeneration of Mitral
      • Valve (Mitral Valve Prolapse)
      • ballooning back during systole
      • one of most common valvular heart
      • diseases
      • a)  incidence in women
      • b) usually presents as incidental finding on physical exam
      www.freelivedoctor.com
    • c) affected leaflets are thickened i) due to mucoid deposits (“ Myxomatous ”) ii) cords are usually elongated thinned and often ruptured iii) annular dilation characteristic - leaflets balloon - rare in other mitral insufficiencies iv) thrombi formation - behind ballooned cusps (on leaflets) www.freelivedoctor.com
    • www.freelivedoctor.com
    • www.freelivedoctor.com
    • d) clinical: i) most asymptomatic - midsystolic “click” ii) ~3 % develop complications: - infective endocarditis - mitral insufficiency (requiring surgery) - stroke - arrhythmias (atria & ventricular - - “sudden death”) iii) if complications  surgery www.freelivedoctor.com
      • Rheumatic Fever and Heart Disease
      • RF is acute inflammation
      • a) within weeks following group A streptococcal pharyngitis
      • i) cross reaction of Ab directed at M proteins of Strep. proteins with glycoprotein Ag in heart, etc.
      • b) acute carditis (RF) may develop to chronic RHD
      www.freelivedoctor.com
    • c) consequence of RF is chronic valvular deformities (fibrosis) i) mitral and aortic - mainly mitral stenosis - permanent www.freelivedoctor.com
      • Pathology :
      • a) RF  focal inflammatory lesions
      • i) “Aschoff” bodies
      • - swollen eosinophilic collegen
      • - found is any layer of the heart (“pancarditis”
      • - in pericardium  fibrinous or serofibrinous exudate
      • ii) “Anitschkow” cells
      • - swollen macrophages and/or plasma cells
      www.freelivedoctor.com
    • www.freelivedoctor.com
    • b) RHD – chronic i) organized acute inflammation - fibrosis  ii) leaflet thickening iii) commissure fusion (stenosis) - “buttonhole” or “fishmouth” stenoses iv) cord fusion / thickening v) Aschoff bodies replaced with fibrous scar www.freelivedoctor.com
    • Stenotic mitral Valve seen from left atrium. Both commissures are fused; the cusps Are severely thickened.The left atrium is huge. The valve is both incompetent and stenotic www.freelivedoctor.com
    • www.freelivedoctor.com
    • Opened stenotic mitral valve showing thickening distorted cusps, adherent commissures with calcification and thrombus deposition, and thickening, fusion and shortening of chordae tendinae www.freelivedoctor.com
    • vi) major cause of mitral stenosis - ~ 99% - mitral valve alone ~ 70% - mitral / aortic valve ~ 25% c) etiology unknown i) believed to result from connective tissue defects -  in Marfan Syndrome www.freelivedoctor.com
      • Clinical:
      • a) migratory polyarthritis
      • i) large joints
      • b) carditis
      • c) s.c. nodules
      • d) erythema marginatum
      • e) Chorea movements (CNS)
      • (Sydenham Chorea)
      • (“St. Vitus Dance”)
      www.freelivedoctor.com
    • s.c. nodule   www.freelivedoctor.com
      • Infective Endocarditis
      • Most cases are bacterial
      • Classification based on clinical grounds
      • a) acute
      • i) destructive (necrotic, ulcerative) valvular infections
      • ii) highly virulent
      • iii) frequently of healthy valve
      • iv) ~ 50% lethal: days to weeks
      • - despite antibiotics/surgery
      www.freelivedoctor.com
    • www.freelivedoctor.com
      • b) Subacute
      • i) low virulence
      • ii)  recovery with antibiotic Tx
      • iii) vegetative growths show signs of healing
      • Etiology and Pathogenesis
      • a) may develop on normal valves
      • b) most develop as result of:
      • i) RHD
      • ii) myxomatous mitral valve
      • - most common today
      www.freelivedoctor.com
    • iii) other factors - calcific stenosis - prosthetic valves - bicuspid aortic valve - immunodeficiency - neutropenia - diabetes - alcohol c) causative organisms i) Strep viridans (50-60%) - previously damaged native valve www.freelivedoctor.com
    • ii) Staph aureus (10-20%) - found on skin -  virulence - attack normal or damaged valves - i.v. drug users !! iii) HACEK group - H aemophilus - A ctinobacillus - C ardiobacterium - E ikenella - K ingella www.freelivedoctor.com
      • iv) Prosthetic valves
      • - Staph epidermidis
      • - Staph aureus
      • v) gram (-) bacilli and fungi
      • Seeding of blood with microbes main
      • cause
      • a) dental or surgical procedures, etc
      • Aortic and mitral valves most common
      • a) right sided valves in i.v. drug abusers
      • Clinical:
      • a) rapid fever (acute IE)
      www.freelivedoctor.com
    • i) chills ii) weakness iv) immune mediated GN v) murmurs (~90%) - left side lesions b) subacute (mild or absent T o ) - fatigue - flu-like symptoms - weight loss www.freelivedoctor.com
    • www.freelivedoctor.com Common Manifestations of Infective Endocarditis . Splinter hemorrhages (Panel A) are normally seen under the fingernails. Panel B shows conjunctival petechiae. Osler's nodes (Panel C) are tender, subcutaneous nodules, often in the pulp of the digits or the thenar eminence. Janeway's lesions (Panel D) are nontender, erythematous, hemorrhagic, or pustular lesions, often on the palms or soles.
      • Non Infective Endocarditis
      • Nonbacterial Thrombotic Endocarditis
      • (NBTE)
      • a) sterile, nondestructive
      • b) small masses of fibrin, platelets, etc.
      • i) on leaflets of cardiac valves
      • c) often seen in debilitated pts
      • i) cancer
      • d) may produce emboli
      • i) stroke in brain, heart, etc.
      www.freelivedoctor.com
    • e) frequently occur with DVT and PE i) common origin with hypercoagulable states - may be related to some underlying disease, such as pancreatic cancer, leukemia, burns and sepsis, DIC - indwelling catheters (SG) induce right valve lesions www.freelivedoctor.com
      • Libman-Sacks Disease
      • a) associated with the autoimmune disease SLE
      • i) mitral and aortic valves
      • - mitral more common
      • - underneath valves
      • - on cords
      • b) sterile vegetations
      • c) regurgitation
      www.freelivedoctor.com
    • www.freelivedoctor.com
      • Carcinoid Heart Disease
      • a) associated with systemic syndrome caused by carcinoid tumors
      • i) ~ 50% of patients with carcinoid syndrome
      • - flushing of skin
      • - cramps
      • - vomitting
      • - diarrhea
      • i) endocardium
      • ii) valves of right heart (~90%)
      • b) serotonin correlate with severity
      www.freelivedoctor.com