Your SlideShare is downloading. ×
0
Factor XII Plasma Prekallikrein Plasma kallikrein HMW  Kininogen Bradykinin Kininases (ACE) Inactive  Fragments LMW  Kinin...
Kinins <ul><li>Pharmacological effects </li></ul><ul><li>Vasodilation + ↑ capilary permeability </li></ul><ul><li>Extravas...
Role in the Kidney – Control of Na Excretion BN-Ki BN-Ka BN-Ki BN-Ka www.freelivedoctor.com
○  BN-Kitasoco ●  BN-Katholiek Influence of NaCl load on systolic BP in 2 strains of rats Influence of various  Na diets a...
www.freelivedoctor.com
www.freelivedoctor.com
Ebelactone B Ebelactone B Systolic Blood  Pressure (mmHg) Age (weeks) Age (weeks) BN-Ki BN-Kath Veh EbelB www.freelivedoct...
Kinins ACE Degradation ACE Inhibitor B2 Icatibant IP 3 ↑   Ca ++ PLA 2 PGI 2 L-arginine NO ↑ cAMP AC GC ↑ cGMP Relaxation ...
Blood Pressure (mmHg) LV Weight (mg/100gBW) R2 R1 V C R1 +H R2 +H R2 R1 V C R1 +H R2 +H Effect of orally administered rami...
Saline Losartan Ramipril + HOE 140 Ramipril www.freelivedoctor.com
Neointimal/Total artery Area (%) Saline  Losartan  HOE 140  Ramipril  Ramipril  + HOE 140 Effect of various treatments on ...
Effect of various treatments on neointima formation  in the carotid artery 2 weeks after  balloon injury Saline L-NAME Ram...
www.freelivedoctor.com
www.freelivedoctor.com
LVP LV  dP/dt HR CF LDH CPK Lactate Lactate Glycogen ATP CP Bradykinin Ramiprilat % Change vs. Control Cardiodynamic Venou...
LVP LV  dP/dt HR CF LDH CPK Lactate Lactate Glycogen ATP CP Cardiodynamic Venous Effluent Myocardial tissue Ramipril Ramip...
Control PC PC+Icat. Icat. BK+Icat. BK Role of Bradykinin in the cardioprotective effects of Ischemic preconditioning on my...
Infarct Size Heart:Body Weight Ratio Moexepril Effect of Chronic Treatment with Moexipril±Icatibant  and Losartan on Infar...
HOE 140 Enalapril Control Enalapril HOE 140 HOE/Enal mg/day Urinary Albumin Excretion Rate in Diabetic Rats www.freelivedo...
ACE Inhibitor AII Receptor Blocker Blocks formation of AII incompletely Blocks Kininase II ↑   Kinins ↓   AII effects  & a...
Potential Uses of Kinin Antagonists <ul><li>Asthma and bronchoconstriction </li></ul><ul><li>Septic Shock </li></ul><ul><l...
Upcoming SlideShare
Loading in...5
×

Kinins

819

Published on

0 Comments
1 Like
Statistics
Notes
  • Be the first to comment

No Downloads
Views
Total Views
819
On Slideshare
0
From Embeds
0
Number of Embeds
1
Actions
Shares
0
Downloads
30
Comments
0
Likes
1
Embeds 0
No embeds

No notes for slide

Transcript of "Kinins"

  1. 1. Factor XII Plasma Prekallikrein Plasma kallikrein HMW Kininogen Bradykinin Kininases (ACE) Inactive Fragments LMW Kininogen Kallidin Tissue kallikrein Tissue Prekallikrein Negatively charged particle glass, LPS, collagen Clotting/fibrinolysis pathway Biological effect thru B2 receptor mainly Plasmin by liver by exocrine glands Factor XIIa Trypsin by liver www.freelivedoctor.com
  2. 2. Kinins <ul><li>Pharmacological effects </li></ul><ul><li>Vasodilation + ↑ capilary permeability </li></ul><ul><li>Extravascular smooth muscle contraction (bronchioles, GI slow rhythmic contraction) </li></ul><ul><li>Stimulation of nerve endings – pain </li></ul><ul><li>Increase in Na excretion in kidney </li></ul><ul><li>Physiological and Pathophysiological Role </li></ul><ul><li>Renal and Cardiovascular Regulation </li></ul><ul><li>Inflammatory Response and Pain </li></ul><ul><li>? Role in the effects of ACE Inhibitors </li></ul>www.freelivedoctor.com
  3. 3. Role in the Kidney – Control of Na Excretion BN-Ki BN-Ka BN-Ki BN-Ka www.freelivedoctor.com
  4. 4. ○ BN-Kitasoco ● BN-Katholiek Influence of NaCl load on systolic BP in 2 strains of rats Influence of various Na diets at week 7 Influence of 2% NaCl diet from 7-11 weeks www.freelivedoctor.com
  5. 5. www.freelivedoctor.com
  6. 6. www.freelivedoctor.com
  7. 7. Ebelactone B Ebelactone B Systolic Blood Pressure (mmHg) Age (weeks) Age (weeks) BN-Ki BN-Kath Veh EbelB www.freelivedoctor.com
  8. 8. Kinins ACE Degradation ACE Inhibitor B2 Icatibant IP 3 ↑ Ca ++ PLA 2 PGI 2 L-arginine NO ↑ cAMP AC GC ↑ cGMP Relaxation Anti-ischemic Anti-proliferative Anti-atherosclerotic + Smooth muscle cell Endothelial cell www.freelivedoctor.com
  9. 9. Blood Pressure (mmHg) LV Weight (mg/100gBW) R2 R1 V C R1 +H R2 +H R2 R1 V C R1 +H R2 +H Effect of orally administered ramipril and coadministration of HOE 140 (BK antagonist) on mean BP and LVW in rats with aortic banding C: sham operation V: control + vehicle R1: ramipril 1 mg/kg R1+H: Ramipril 1mg + HOE 140 R2: ramipril 10 µg/kg R2+H: Ramipril 10µg + HOE 140 www.freelivedoctor.com
  10. 10. Saline Losartan Ramipril + HOE 140 Ramipril www.freelivedoctor.com
  11. 11. Neointimal/Total artery Area (%) Saline Losartan HOE 140 Ramipril Ramipril + HOE 140 Effect of various treatments on neointima formation in the carotid artery 2 weeks after balloon injury www.freelivedoctor.com
  12. 12. Effect of various treatments on neointima formation in the carotid artery 2 weeks after balloon injury Saline L-NAME Ramipril Ramipril + L-NAME Neointimal area/Total artery area % * # + # * P<0.05 vs Saline; +:P<0.05 vs. Ramipril; #: P<0.05 vs. L-NAME www.freelivedoctor.com
  13. 13. www.freelivedoctor.com
  14. 14. www.freelivedoctor.com
  15. 15. LVP LV dP/dt HR CF LDH CPK Lactate Lactate Glycogen ATP CP Bradykinin Ramiprilat % Change vs. Control Cardiodynamic Venous Effluent Myocardial tissue www.freelivedoctor.com
  16. 16. LVP LV dP/dt HR CF LDH CPK Lactate Lactate Glycogen ATP CP Cardiodynamic Venous Effluent Myocardial tissue Ramipril Ramipril + Icatibant Reversal by Kinin Antagonist of Cardioprotective Effect of ACE Inhibitor www.freelivedoctor.com
  17. 17. Control PC PC+Icat. Icat. BK+Icat. BK Role of Bradykinin in the cardioprotective effects of Ischemic preconditioning on myocardial infarct size in the rabbit. PC: 5 min occlusion followed by 10 min reperfusion followed by 30 min occlusion. Similar protection achieved with exogenous BK. Infarct Size www.freelivedoctor.com
  18. 18. Infarct Size Heart:Body Weight Ratio Moexepril Effect of Chronic Treatment with Moexipril±Icatibant and Losartan on Infarct Size and Cardiac Mass Moexepril +Icatibant Losartan Moexepril Moexepril +Icatibant Losartan www.freelivedoctor.com
  19. 19. HOE 140 Enalapril Control Enalapril HOE 140 HOE/Enal mg/day Urinary Albumin Excretion Rate in Diabetic Rats www.freelivedoctor.com
  20. 20. ACE Inhibitor AII Receptor Blocker Blocks formation of AII incompletely Blocks Kininase II ↑ Kinins ↓ AII effects & aldosterone PROTECTION Blocks AT-1R AT-2R Free More complete Inhibition of AII effects Preserve Anti- proliferative effect www.freelivedoctor.com
  21. 21. Potential Uses of Kinin Antagonists <ul><li>Asthma and bronchoconstriction </li></ul><ul><li>Septic Shock </li></ul><ul><li>Hypotension due to pancreatitis </li></ul><ul><li>Inflammation and pain </li></ul><ul><li>Rhinovirus symptoms </li></ul>www.freelivedoctor.com
  1. A particular slide catching your eye?

    Clipping is a handy way to collect important slides you want to go back to later.

×