Actinomycosis

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Actinomycosis

  1. 1. Actinomycetes www.freelivedoctor.com
  2. 2. Actinomycetes (order) <ul><li>Three genera </li></ul><ul><li>Actinomyces species </li></ul><ul><li>Nocardia species </li></ul><ul><li>Streptomyces species </li></ul>www.freelivedoctor.com
  3. 3. Gram Positive Filamentous Bacteria www.freelivedoctor.com GENUS OXYGEN GRANULE ACIDFAST Mycobacteria aerobe no yes Actinomyces ANAEROBE YES no Nocardia aerobe sometime PARTIALLY Streptomyces aerobe YES no
  4. 4. www.freelivedoctor.com
  5. 5. Actinomycosis A chronic suppurative and granulomatous disease of the cervico-facial, thoracic or abdominal areas www.freelivedoctor.com
  6. 6. Actinomycosis www.freelivedoctor.com
  7. 7. Ecological Niche Actinomyces Endogenous (man and animals) www.freelivedoctor.com
  8. 8. www.freelivedoctor.com
  9. 9. CLINICAL SPECIMENS Actinomyces <ul><li>Pus </li></ul>www.freelivedoctor.com
  10. 10. Sulphur granules www.freelivedoctor.com
  11. 11. www.freelivedoctor.com
  12. 12. Drug of Choice <ul><li>Penicillin </li></ul><ul><li>(large doses) </li></ul>www.freelivedoctor.com
  13. 13. Serological Test <ul><li>None available </li></ul>www.freelivedoctor.com
  14. 14. www.freelivedoctor.com
  15. 15. Nocardiosis <ul><li>Subcutaneous infections, pulmonary infections, and brain abscesses </li></ul>www.freelivedoctor.com
  16. 16. Ecological Association Soil Endogenous ? www.freelivedoctor.com
  17. 17. Geographic Distribution <ul><li>World wide </li></ul>www.freelivedoctor.com
  18. 18. Nocardiosis <ul><li>N. asteroides – Pulmonary </li></ul><ul><li>N. brasiliensis - Abscesses </li></ul>www.freelivedoctor.com
  19. 19. www.freelivedoctor.com
  20. 20. www.freelivedoctor.com
  21. 21. Clinical Specimens <ul><li>Sputum </li></ul><ul><li>Pus </li></ul><ul><li>Biopsy tissue </li></ul>www.freelivedoctor.com
  22. 22. www.freelivedoctor.com
  23. 23. Serological Test <ul><li>None available </li></ul>www.freelivedoctor.com
  24. 24. Drug of Choice Sulfamethoxazole-Trimethoprim www.freelivedoctor.com
  25. 25. STREPTOMYCOSIS Streptomyces species www.freelivedoctor.com
  26. 26. Mycetoma <ul><li>Streptomyces species </li></ul>www.freelivedoctor.com
  27. 27. Ecological Association Soil www.freelivedoctor.com
  28. 28. www.freelivedoctor.com
  29. 29. Streptomyces may invade bone www.freelivedoctor.com
  30. 30. Clinical specimens Pus Biopsy material www.freelivedoctor.com
  31. 31. www.freelivedoctor.com
  32. 32. www.freelivedoctor.com
  33. 33. Serological Test None available www.freelivedoctor.com
  34. 34. Treatment <ul><li>Surgical debridement </li></ul><ul><li>Sulfa drugs </li></ul><ul><li>Amphotericin B </li></ul>www.freelivedoctor.com
  35. 35. www.freelivedoctor.com

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