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1  B  Actino
1  B  Actino
1  B  Actino
1  B  Actino
1  B  Actino
1  B  Actino
1  B  Actino
1  B  Actino
1  B  Actino
1  B  Actino
1  B  Actino
1  B  Actino
1  B  Actino
1  B  Actino
1  B  Actino
1  B  Actino
1  B  Actino
1  B  Actino
1  B  Actino
1  B  Actino
1  B  Actino
1  B  Actino
1  B  Actino
1  B  Actino
1  B  Actino
1  B  Actino
1  B  Actino
1  B  Actino
1  B  Actino
1  B  Actino
1  B  Actino
1  B  Actino
1  B  Actino
1  B  Actino
1  B  Actino
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1 B Actino

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  • 1. Actinomycetes Page 3
  • 2. Actinomycetes (order) <ul><li>Three genera </li></ul><ul><li>Actinomyces species </li></ul><ul><li>Nocardia species </li></ul><ul><li>Streptomyces species </li></ul>
  • 3. Gram Positive Filamentous Bacteria no YES aerobe Streptomyces PARTIALLY sometime aerobe Nocardia no YES ANAEROBE Actinomyces yes no aerobe Mycobacteria ACIDFAST GRANULE OXYGEN GENUS
  • 4. &nbsp;
  • 5. Actinomycosis A chronic suppurative and granulomatous disease of the cervico-facial, thoracic or abdominal areas
  • 6. Actinomycosis Actinomyces israelii
  • 7. Ecological Niche Actinomyces Endogenous (man and animals)
  • 8. &nbsp;
  • 9. CLINICAL SPECIMENS Actinomyces <ul><li>Pus </li></ul>
  • 10. Sulphur granules
  • 11. &nbsp;
  • 12. Drug of Choice <ul><li>Penicillin </li></ul><ul><li>(large doses) </li></ul>
  • 13. Serological Test <ul><li>None available </li></ul>
  • 14. &nbsp;
  • 15. Nocardiosis <ul><li>Subcutaneous infections, pulmonary infections, and brain abscesses </li></ul>
  • 16. Ecological Association Soil Endogenous ?
  • 17. Geographic Distribution <ul><li>World wide </li></ul>
  • 18. Nocardiosis <ul><li>N. asteroides – Pulmonary </li></ul><ul><li>N. brasiliensis - Abscesses </li></ul>
  • 19. &nbsp;
  • 20. &nbsp;
  • 21. Clinical Specimens <ul><li>Sputum </li></ul><ul><li>Pus </li></ul><ul><li>Biopsy tissue </li></ul>
  • 22. &nbsp;
  • 23. Serological Test <ul><li>None available </li></ul>
  • 24. Drug of Choice Sulfamethoxazole-Trimethoprim
  • 25. STREPTOMYCOSIS Streptomyces species
  • 26. Mycetoma <ul><li>Streptomyces species </li></ul>
  • 27. Ecological Association Soil
  • 28. &nbsp;
  • 29. Streptomyces may invade bone
  • 30. Clinical specimens Pus Biopsy material
  • 31. &nbsp;
  • 32. &nbsp;
  • 33. Serological Test None available
  • 34. Treatment <ul><li>Surgical debridement </li></ul><ul><li>Sulfa drugs </li></ul><ul><li>Amphotericin B </li></ul>
  • 35. &nbsp;

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