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Worm timing paper
Worm timing paper
Worm timing paper
Worm timing paper
Worm timing paper
Worm timing paper
Worm timing paper
Worm timing paper
Worm timing paper
Worm timing paper
Worm timing paper
Worm timing paper
Worm timing paper
Worm timing paper
Worm timing paper
Worm timing paper
Worm timing paper
Worm timing paper
Worm timing paper
Worm timing paper
Worm timing paper
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Worm timing paper

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  • 1. Gene transcription is coordinated with, but not dependent on, cell divisions during C. elegans embryonic fate specification! Gautham  Nair,  Travis  Walton,  John  Isaac  Murray,  and  Arjun  Raj   University  of  Pennsylvania  Department  of  Bioengineering   University  of  Pennsylvania  Department  of  GeneDcs  
  • 2. RNA-FISH! 10µm! RNA!
  • 3. Automated Lineaging!
  • 4. Gut genes! Wild type 20C!
  • 5. Transcription is slowed LESS?
  • 6. Transcription is slowed MORE?
  • 7. Transcription is slowed THE SAME?
  • 8. Transcription is slowed THE SAME
  • 9. Transcription is slowed THE SAME - many other genes - clk-1 mutant slowdown
  • 10. Transcription is slowed THE SAME - many other genes - clk-1 mutant slowdown
  • 11. Transcription is slowed THE SAME Total Number of Cells in Embryo
  • 12. Total Number of Cells in Embryo
  • 13. Total Number of Cells in Embryo Transcription is DEPENDENT on cell divisions?
  • 14. emb-29(g52) mutant Total Number of Cells in Embryo Transcription is DEPENDENT on cell divisions? NO
  • 15. Transcription is DEPENDENT on cell divisions? NO - elt-2 in E lineage - hlh-1 and unc-120 in muscle pathway
  • 16. Transcription is DEPENDENT on cell divisions? NO - elt-2 in E lineage - hlh-1 and unc-120 in muscle pathway
  • 17. Transcription is DEPENDENT on cell divisions? NO - elt-2 in E lineage - hlh-1 and unc-120 in muscle pathway
  • 18. Gene transcription is coordinated with, but not dependent on, cell divisions during C. elegans embryonic fate specification!
  • 19. Gene transcription is coordinated with, but not dependent on, cell divisions during C. elegans embryonic fate specification! Funding:     HHMI  Life  Sciences  Research  FoundaDon  Fellowship   Burroughs-­‐Wellcome  Fund   NIH  New  Innovator  Award   Penn  Genome  FronDers  InsDtute   Pennsylvania  Department  of  Health  

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