FLUID DISTURBANCES
1
WATER IS
50% OF BODY WEIGHT IN WOMEN
60% IN MEN

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Intracellular fluid (ICF)
• Largest compartment – 60%
• Main cation – potassium
• Anions - phosphates and bicarbonate

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3
ECF = 40%
• Main cation – sodium
• Anions - chloride and bicarbonate

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4
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5
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6
If 1 L of solute-free water is lost from the body, how
much fluid is lost by the ICF compartment?
7

 Water ICF : ECF = 2...
Lose of 1L of iso-osmotic fluid
8

 ECF compartment will decrease by 1 L
 Na+ is largely restricted to the ECF

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Osmolality and osmolarity
9

 Often used interchangeably
 Osmolality
 Number of solutes per mass of water
 Osmolarity
...
Solutes
10

 Extracellular and intracellular solutes (or

osmoles)


Markedly different

 Water
 Moves across cell mem...
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FLUID DISTURBANCES

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FLUID DISTURBANCES

  1. 1. FLUID DISTURBANCES 1 WATER IS 50% OF BODY WEIGHT IN WOMEN 60% IN MEN www.medicinemcq.com
  2. 2. Intracellular fluid (ICF) • Largest compartment – 60% • Main cation – potassium • Anions - phosphates and bicarbonate www.medicinemcq.com 2
  3. 3. www.medicinemcq.com 3
  4. 4. ECF = 40% • Main cation – sodium • Anions - chloride and bicarbonate www.medicinemcq.com 4
  5. 5. www.medicinemcq.com 5
  6. 6. www.medicinemcq.com 6
  7. 7. If 1 L of solute-free water is lost from the body, how much fluid is lost by the ICF compartment? 7  Water ICF : ECF = 2:1 ratio  Solute-free water loss  Twofold greater reduction in the ICF compartment than the ECF compartment  Volume loss  ICF = 667 mL  ECF = 333 mL www.medicinemcq.com
  8. 8. Lose of 1L of iso-osmotic fluid 8  ECF compartment will decrease by 1 L  Na+ is largely restricted to the ECF www.medicinemcq.com
  9. 9. Osmolality and osmolarity 9  Often used interchangeably  Osmolality  Number of solutes per mass of water  Osmolarity  Number of moles of solute in a liter of solution www.medicinemcq.com
  10. 10. Solutes 10  Extracellular and intracellular solutes (or osmoles)  Markedly different  Water  Moves across cell membranes  Distributes between ICF and ECF  Until the osmolality is the same  For rest of the slides visit www.medicinemcq.com Nephrology www.medicinemcq.com

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