Your SlideShare is downloading. ×
0
Microencapsulation ppt by Riteksha
Microencapsulation ppt by Riteksha
Microencapsulation ppt by Riteksha
Microencapsulation ppt by Riteksha
Microencapsulation ppt by Riteksha
Microencapsulation ppt by Riteksha
Microencapsulation ppt by Riteksha
Microencapsulation ppt by Riteksha
Microencapsulation ppt by Riteksha
Microencapsulation ppt by Riteksha
Microencapsulation ppt by Riteksha
Microencapsulation ppt by Riteksha
Microencapsulation ppt by Riteksha
Microencapsulation ppt by Riteksha
Microencapsulation ppt by Riteksha
Microencapsulation ppt by Riteksha
Microencapsulation ppt by Riteksha
Microencapsulation ppt by Riteksha
Microencapsulation ppt by Riteksha
Microencapsulation ppt by Riteksha
Microencapsulation ppt by Riteksha
Microencapsulation ppt by Riteksha
Microencapsulation ppt by Riteksha
Microencapsulation ppt by Riteksha
Microencapsulation ppt by Riteksha
Microencapsulation ppt by Riteksha
Microencapsulation ppt by Riteksha
Microencapsulation ppt by Riteksha
Microencapsulation ppt by Riteksha
Microencapsulation ppt by Riteksha
Upcoming SlideShare
Loading in...5
×

Thanks for flagging this SlideShare!

Oops! An error has occurred.

×
Saving this for later? Get the SlideShare app to save on your phone or tablet. Read anywhere, anytime – even offline.
Text the download link to your phone
Standard text messaging rates apply

Microencapsulation ppt by Riteksha

691

Published on

Microencapsulation, …

Microencapsulation,
Definition
Need of Microencapsulation
Advantages
Fundamental consideration
Techniques
Applications

Published in: Education, Technology, Business
1 Comment
4 Likes
Statistics
Notes
No Downloads
Views
Total Views
691
On Slideshare
0
From Embeds
0
Number of Embeds
0
Actions
Shares
0
Downloads
0
Comments
1
Likes
4
Embeds 0
No embeds

Report content
Flagged as inappropriate Flag as inappropriate
Flag as inappropriate

Select your reason for flagging this presentation as inappropriate.

Cancel
No notes for slide

Transcript

  • 1. PRESENTED BY: Riteksha Patel M.Pharma (pharmaceutics)
  • 2.  Definition  Need of Microencapsulation  Advantages  Fundamental consideration  Techniques  Applications  References
  • 3. DEFINITION: A process by which solid , droplets of liquid and dispersion can be enclosed in microscopic particle by the formation of thin coating of wall material around the substance. INTRODUCTION Core material Wall material Coating
  • 4. NEED OF MICROENCAPSULATION: Entrapment of a material inside microparticles for  immobilized it  protect it  release it  structure it
  • 5.  To Increase of bioavailability.  To alter the drug release.  To produce a targeted drug delivery.  To protect the core from outside environment.  To decrease evaporation rate of the volatile core material.  To convert liquid into solid form.  To mask the core taste.  Protects the GIT from irritant effects of the drug.
  • 6. FUNDAMENTAL CONSIDERATION: Core material Coating material Vehicle Solid Liquid Microencapsulation Polymers Waxes Aqueous No aqueous Resins Proteins Polysaccharides
  • 7.  The material to be coated.  It may be liquid or solid in nature.  Liquid core may be dissolved or dispersed material. COMPOSITION OF CORE MATERIAL:  Drug or active constituent  Additive like diluents CORE MATERIAL:
  • 8. IDEAL CHARACTERISTICS:  Capable of forming a film cohesive with core material.  It should be compatible with the core material.  It Should be stable, non reactive.  Provide desired coating properties like strength, flexibility& impermeability. COMPOSITION OF COATING:  Inert polymer  Plasticizer  Coloring agent COATING MATERIAL:
  • 9. 1. MICROENCAPSULATION TECHNIQUES: 1. Air suspension technique (Wurster) 2. Coacervation-Phase separation process 3. Spray drying & spray congealing 4. Multiorifice Centrifugation Process 5. Pan coating 6. Solvent evaporation 7. Polymerization 8. Nozzle vibration technology 9. Jet cutter technology 10. Extrusion 11. Single & double emulsion techniques 12. Supercritical fluid anti solvent method (SAS)
  • 10. 10 MICROENCAPSULATION PROCESSES & THEIR APPLICABILITIES:
  • 11. 1.WURSTER PROCESS:
  • 12. Polymeric Membrane Droplets Homogeneous Polymer Solution Coacervate Droplets PHASE SEPARATION MEMBRANE FORMATION 1.Formation of three immiscible phases 2.Deposition of coating 3.Rigidization of coating
  • 13.  Used for large size particles i.e. 600-5000 μm size.  Coating pan is used for this operation.  Coating solution is applied as a solution or atomized spray on sugar pellets (Non-pareil sugar seeds).  Warm air is passed to remove the coating solvent.
  • 14. Polymer + Volatile organic solvent Organic Polymeric Phase Formation of Oil-in-Water Emulsion Solvent Evaporation Particle Formation by Polymer Precipitation RECOVERY OF POLYMERIC MICROPARTICLES Temperature increase Active Ingredient Addition into an aqueous phase (+o/w stabilizer) 5.SOLVENT EVAPORATION:
  • 15. 6.SPRAY DRYING & CONGEALING : Spray drying : spray = aqueous solution / Hot air Spray congealing : spray = hot melt/cold air
  • 16. 7.POLYMERIZATION: Method developed by Chang Interfacial polymerization.. Aliphatic diamine Dicarboxilic acid halide Liq- Liq. interface polymerization Microspheres
  • 17. (D) Vibration technology •This technology is based on an ancient principle (Lord Rayleigh, in the late 19th century) which shown that a laminar liquid jet breaks up into equally sized droplets by a superimposed vibration. The parameters are the frequency, the velocity of the jet and the nozzle diameter. •To guarantee the production of uniform beads or capsules and to avoid large size distributions due to coalescence effects during the flight, the droplets pass through an electrostatic field to be charged. As a result these droplets don’t hit each other during the flight and will be spread over a larger surface of the gelation bath thus resulting in monodisperse beads.
  • 18. (E) JetCutter technology The JetCutter is a simple technology for bead production that meets the requirement of producing monodisperse beads originating from low up to high viscous fluids with a high throughput `
  • 19. APPLICATION OF MICROENCAPSULATION:
  • 20. ADVANTAGE OF MICROENCAPSULATION • administered dose of a drug is subdivided into small units that are spread over a large area of the gastrointestinal tracts, which may enhance absorption by diminishing local drug concentration • Micro-K ExtenCaps
  • 21.  Its costly process, not economical.  More skill is required.  It is difficult to get continuous & uniform film.
  • 22. 1.Microcapsules: The active agent forms a core surrounded by an inert diffusion barrier. 2.Microspheres: The active agent is dispersed or dissolved in an inert polymer.
  • 23.  Stability testing  Size of microcapsules- Sieving Method  Amount of drug present In microcapsules  Dissolution test- Invitro drug release
  • 24.  Leon, L., Herbert A. L., Joseph, L. K; “ The Theory And Practice Of Industrial Pharmacy”, 3rd edition (1990), Varghese Publishing House, Page no. 412-428.  Vyas S.P, Khar R.K; “Targeted & Controlled drug delivery ’’ Novel carrier systems,1st edition (2002),CBS publisher & distributors New delhi, page no.418-455.  Wise D.L, “Handbook of pharmaceutical controlled release technology”1st edition , Marcel Dekker New York, page no. 271-286,

×