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Hemophilia

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Hemophilia

Hemophilia

Published in: Health & Medicine, Technology

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  • 1. Haimo- blood Philia- love
  • 2. a group of hereditary genetic disorders that impair the body's ability to control blood clotting or coagulation  Most common to males  Hemophilia has featured prominently in European royalty and thus is sometimes known as 'the royal disease'. 
  • 3. The first medical professional to describe a disease was Abulcasis during the 10th century.  The term "haemophilia" is derived from the term "haemorrhaphilia" which was used in a description of the condition written by Friedrich Hopff in 1828, while he was a student at the University of Zurich. 
  • 4. Genetic mutation: - genes that code for proteins that are essential in the blood clotting process  The protein involved with hemophilia A is factor VIII (factor 8)  hemophilia B is factor IX (factor 9). 
  • 5. known family history of the condition  series of blood tests    platelet (a blood particle essential for the clotting process)   the prothrombin time (PT) and activated partial thromboplastin time (aPTT) 
  • 6. Mild hemophilia  bleed excessively in response to injury or trauma Severe hemophilia  Heavy bleeding can occur anywhere in the body.
  • 7. Hemarthrosis  Bleeding into the muscles  Bleeding from the mouth or nosebleeds   Bleeding from the gastrointestinal tract   Bleeding from the urinary tract  Intracranial hemorrhage  Increased bleeding after surgery or trauma 
  • 8. Replacement of the blood clotting factors. - purified from human donor blood or made in the laboratory using methods that do not use donor blood - infusing the clotting factor concentrates into a vein  Drug desmopressin   Acetaminophen (Tylenol and others) 
  • 9. Hemophilia is rare, with only about 1 instance in every 10,000 births (or 1 in 5,000 male births) for hemophilia A and 1 in 50,000 births for hemophilia B. About 18,000 people in the United States have hemophilia. Each year in the US, about 400 babies are born with the disorder. It is estimated that about 2500 Canadians have hemophilia A, and about 500 Canadians have hemophilia B.