QUANTIFYING MY GENETICS: <ul><li>WHY I AM BANNED FROM CAFFEINE </li></ul>CHIA HWU @CHIAH QUBOP INC. QUANTIFIED SELF EUROPE CONFERENCE AMSTERDAM, NETHERLANDS 2011
CAFFEINE METABOLISM <ul><li>MARKER: SNP RS762551 ON CHROMOSOME 15 </li></ul>
"People with the slower version of the CYP1A2 enzyme who also drank at least two to three cups of coffee per day had a significantly increased risk of a non-fatal heart attack ...fast metabolizers, on the other hand, may have actually reduced their heart attack risk by drinking coffee." Cornelis MC et al. (2006) . “Coffee, CYP1A2 genotype, and risk of myocardial infarction.” JAMA 295(10):1135-41.
CAFFEINE EFFECTS: SUBJECTIVE VS. OBJECTIVE CUPS OF COFFEE (DECAF) DEGREE OF AGITATION
ALCOHOL FLUSH REACTION <ul><li>MARKER: SNP RS671 ON CHROMOSOME 12 </li></ul>
"The ALDH2 gene encodes a protein ...responsible for the second step of ethanol processing: the conversion of the highly toxic acetaldehyde to the harmless acetic acid (vinegar)...Having two copies of this version results in an extremely unpleasant experience when drinking"
ALCOHOL EFFECTS: SUBJECTIVE VS. OBJECTIVE NUMBER OF DRINKS DEGREE OF INTOXICATION & ILLNESS (VIOLENT NAUSEA)
ALCOHOL EFFECTS: RECOVERY TIME NUMBER OF DRINKS DAYS TO NORMALCY
<ul><li>This process makes a person so sensitive to alcohol that it can be used to treat alcoholics. </li></ul>