Mutations and Proteins slide

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Mutations and Proteins slide

  1. 1. MUTATION ANDPROTEINS
  2. 2. WARM-UP• Finish the Pre-lab on your Enzyme Lab handout.• Announcements• - 8 days until DNA Exam• - US Geological Survey Paid Internship Program• - Guest Speaker Tomorrow• - Return the UV Light Box – 5 people• - Dissecting Scopes from Jay Vavra – 2 people
  3. 3. MutationsMutations are changes in the genetic material of a cell
  4. 4. MutationsPoint mutations are changes in one base pair of a genea. What would the series of nucleotides in mRNA transcribed from this strand be? AUG UGG GAG CAU UGAa. List the codons from the mRNA coded for by this series of DNA?b. If the sequence of DNA nucleotides above is a complete gene that codes for a protein, what are the amino acids that make this protein? Start(Met) Trp Glu His Stop
  5. 5. Mutations• How are the proteins for each DNA sequence different? They’ re not• This is an example of point mutation called a silent mutation
  6. 6. Mutations• What would the series of nucleotides in mRNA transcribed from this strand be? AUG UGG GUA CAU UGA• List the codons from the mRNA coded for by this series of DNA?• If the sequence of DNA nucleotides above is a complete gene that codes for a protein, what are the amino acids that make this protein? Start(Met) Trp Val His Stop• How are the proteins for each DNA sequence different? Glu into Val• This is an example of a type of point mutation called a missense• The last type of point mutation is called a nonsenseSickle Cell Anemia:http://www.pbs.org/wgbh/evolution/library/01/2/l_012_02.html
  7. 7. MutationsA frame shift mutation is when a certain number of nucleotides areinserted or deleted in the reading frame of a gene…what would the RNA sequence of the original strand and the mutatedstrand be? AUGGGGAACAUUGAIf the sequence of DNA nucleotides above is a complete gene thatcodes for a protein, what are the amino acids that make this protein? Start-Gly-Asn-Ile- vs. Start Trp Glu His StopHow are the proteins for each DNA sequence different?Every single protein is different and there is no stop codonThis type of frameshift mutation is called a(n) deletion
  8. 8. How do Mutations occurDNA replicationMutagens can be physical or chemical - physical: UV or Xrays - chemical: imidazole or EtBr (ethidium bromide)

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