Isotonix Spectrum Multivitamin Qstore99


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Might-a-Mins® Spectrum Isotonix® Multivitamin provides children with the vitamins and minerals they need for optimal health. Many children do not obtain the necessary amounts of vitamins and minerals due to high consumption of processed foods, poor nutrient absorption and exposure to environmental toxins. Might-a-Mins Spectrum Isotonix Multivitamin provides children in need of neurological, metabolic or digestive support with a strong micronutrient foundation which promotes healthy development and supports optimal immune functions.

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  • Thank you, Tanya. Various ingredients that have shown a role in helping those with neurological and digestive health issues. To date, there have been countless studies documenting these effects and, because it is such a hot topic, I am sure new studies are on the horizon. Some of those ingredients include (but are certainly not limited to), Read lists.
  • I’m sure many of you have heard of folic acid, an important B vitamin. The big question is does your child get enough folic acid…leafy greens, like spinach or turnip greens in his diet? Folic acid is a very important vitamin for many processes in the body, specifically for the nervous system. (give some specific examples)Folinic acid is the metabolically active form of folic acid, meaning one less step is required for it’s conversion in the body. Folic acid has to be activated but by using folinic acid, it’s more readily available. Folinic acid aids in the conversion of sulfur-containing compounds to glutathione, and glutathione is an antioxidant found in the body. Studies on folinic acid have shown improvements in sleep, communication, social interaction in those with neurological, metabolic and digestive needs . The Better-Worse ratio is 11:1, meaning supplementation with folic acid caused 11 children to get better for every one that got worse.
  • Another extremely important vitamin is vitamin B6. Food sources include beans, meat, poultry, fish, and some fruits and vegetables . Pyridoxal-5-phosphate is the active form of vitamin B6 and it has been shown that the conversion to P5P is problematic in some children. Some studies have shown a low activity of pyridoxal kinase, which is the enzyme required for the conversion to P5P . For this reason, it is best to only supplement with the P5P form. B6 is involved in the synthesis of neurotransmitters in the brain and peripheral nerve cells, which are critical for the development of language, attention, alertness, etc.
  • B6 also acts as a cofactor for enzymes that degrade oxalates. Oxalates are molecules that are present in many plants and fruits and almost every seed and nut. Becomes more of a problem when the gut is leaky, because higher quantities of oxalates will be absorbed from foods. B6 helps degrade oxalates so they are not absorbed. High oxalates can cause frequent urination, GI pain. Why is this important to this discussion? Because oxalates appear increased in the urine in certain individuals with impaired neurological function.
  • Read Slide - The combination of B6 and magnesium has been described by many as a “breakthrough intervention” for children with increased needs in brain and digestive health. Significant improvements in behavior, better eye contact, fewer tantrums, improved sleep patterns, better speech, etc., have been consistently reported using vitamin B6 and magnesium. You may wonder why does the combination of Vitamin B6 and magnesium have such an effect? B6 improves and supports nerve impulse conduction and blood flow in the brain. By the same token, magnesium, acts as a vasodilator, allowing for better circulation of oxygen and nutrients to the brain. These nutrient almost always lead back to brain health. B6 and magnesium combination has 11:1 B:W ratio
  • Vitamin B12 is naturally found in foods that come from animals, including fish, meat, poultry. It’s vitamin needed for many processes, including nerve cell activity, DNA replication. It’s best to use methylcobalamin, rather than cobalamin, as evidence indicates this form is utilized much more efficiently. Again, this vitamin is necessary for glutathione production. A vitamin B12 deficiency is common in children with neurological, metabolic and digestive needs. evidence for transmethylation defects
  • It’s best to use methylcobalamin, rather than cobalamin, as evidence indicates this form is utilized much more efficiently, especially in children with methylation defects . Every cell in the body expresses the folate/methionine cycle, defects in transmethylation can affect vital biochemical reactions at many places in metabolism. This is important, as some children do have methylation defects. So it makes sense to consume B12 in a form in which it's already metabolically active and maximally reduced, and thereby put less of a strain on our bodies' antioxidative capacity.
  • You’re all familiar with vitamin C, also known as ascorbic acid. Food sources include many fruits and vegetables. The vitamin is essential for tissue repair, wound and bone healing, immune function among it’s antioxidant capabilities. Vitamin C is also a cofactor for dopamine production which helps to maintain brain health, as dopamine has important roles in behavior and cognition, motivation and reward, sleep, mood, attention, and learning. It’s also helps elevate glutathione production. B:W Ratio – 19.1!!!
  • Vitamin C supported red blood cell glutathione levels by 50% in college students
  • Zinc is a mineral that can be found in the following food sources…oysters, red meat, beans, nuts and grains etc. is an essential mineral that is a component of more than 300 enzymes needed to repair wounds, synthesize proteins, aid in the development and maintenance of the brain, help cells reproduce, preserve vision, boost immunity, and protect against free radicals, among many other functions. It is a known fact that when zinc levels are down, copper levels are often increased. 90% of children with neurological and digestive needs have this abnormal zinc to copper ratio. Excess copper can lead to copper imbalance in the body and organs and copper imbalance in children is associated with delayed development, anti-social and hyperactive behavior, and learning difficulties. Because zinc helps facilitate the excretion of excess copper, it is important to make sure a multivitamin has an adequate amount of zinc. You should avoid copper-containing supplements for these children. Also, the B:W ratio for zinc is 22:1, even higher than that of vitamin C!
  • I know you’re all familiar with calcium and the many important functions it has in the body. Calcium sources are easy, milk cheese, green leafy veggies. We know calcium is good for everyone as it is an essential component of many processes in the body. Specifically, calcium has been shown to reduce oxalate absorption (oxalates are much higher in people with impaired neurological function). When calcium is taken with foods high in oxalates, the oxalic acid combines with the calcium to form calcium oxalate crystals which can be eliminated in the stool. This excretion through the stool prevents the oxalic acid from being absorbed into the body, binding with the calcium within the blood, forming calcium oxalate crystals there, resulting in urinary problems and pain . Also, calcium deficiency is common among these types children. Many of these individuals are on a casein-free (no milk) diet, so it’s especially important to supplement with calcium. The Better:Worse ratio for calcium is 14:1.
  • Magnesium is another mineral that you’re probably familiar with. Food sources include green vegetables, like spinach and beans and peas, among others. How many of you or your kids eat healthy amounts of spinach? Probably not very many. Magnesium is an essential mineral required by many enzymes to function properly, specifically those enzymes responsible for the production of neurotransmitters in the brain. As mentioned before, magnesium in combination with vitamin B6 has shown remarkable results among certain children, including improved communication and better social interaction. Magnesium in combination with B6 has been described as breakthrough intervention for children with neurological, metabolic and digestive needs.
  • In support of the use of these ingredients for certain children, Adams and others conducted a small pilot study using a strong, balanced multivitamin/multimineral formulation. 20 children ages 3-8 years old with neurological and digestive issues. This formulation included the P5P form of vitamin B6, magnesium, zinc, vitamin C, vitamin B12, calcium, among others. The results clearly indicated statistically significant improvements in sleep and GI health. They also determined a functional need for more B6 and vitamin C in these individuals.
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  • Isotonix Spectrum Multivitamin Qstore99

    1. 1. Isotonix Might-a-Mins ®Spectrum Multivitamin Crystal H. Shelton Research Associate Scientific Affairs
    2. 2. Isotonix Might-a-Mins ® Spectrum MultivitaminThese statements have not been evaluated by the Foodand Drug Administration. This product is not intended todiagnose, treat, cure or prevent any disease.
    3. 3. Important Ingredients for Neurological, Metabolic and Digestive Support Folic Acid  Vitamin A Vitamin B6 (P5P)  Zinc Vitamin B12  Calcium Vitamin B3  Magnesium Vitamin C
    4. 4. Folinic Acid Food sources include:  Essential for numerous  Leafy green vegetables processes in the body and (like spinach and turnip supports the normal greens), fruits (like citrus fruits and juices), and development of the nervous dried beans and peas are system all natural sources of folate  Folinic acid (tetrahydrofolic acid)is the metabolically active form of folic acid, high bioavailability
    5. 5. Folinic Acid Supports the conversion of sulfur-containing compounds to glutathione, studies show low glutathione due to abnormalities in methionine pathway  Antioxidant  Detoxification Because of folic acid’s critical role in neurological function, it can help to maintain healthy sleep quality, and help facilitate the normal development of communication and social interaction skills 11:1
    6. 6. Vitamin B6 (P5P or Pyridoxine-5-Phosphate) Food sources include:  B6 is critical for the normal  Beans, meat, poultry, fish, development of language, attention, alertness, etc. and some fruits and vegetables  To be used by the body, B6 must be converted to P5P in Master vitamin for numerous the liver metabolic pathways in the body Pyridoxal-5-phosphate is the active form of vitamin B6
    7. 7. B6 and Oxalates Acts as a cofactor for enzymes that degrade oxalates  Molecules present in many plants and fruit, all seeds and nuts, grains  When the gut is leaky higher quantities of oxalates are absorbed from foods
    8. 8. Vitamin B6 (P5P or Pyridoxine-5-Phosphate) Vitamin B6 is the most studied nutrient among children with neuroglogical, metabolic and digestive issues and is often given in combination with magnesium. B6 naturally requires extra magnesium to be effective 11:1
    9. 9. Methylcobalamin (Vitamin B12) Food sources include:  Promotes normal  Naturally found in foods that conversion of sulfur- come from animals, including containing compounds to fish, meat, poultry, eggs, milk, glutathione (antioxidant and milk products and detox) A water-soluble vitamin  Vitamin B12 deficiency is that supports normal commonly found in nerve cell activity, DNA children with neurological, replication, and metabolic and digestive production of the mood- needs affecting substance SAMe (S-adenosyl-L- methionine)
    10. 10. Methylcobalamin (Vitamin B12) Methylated form of B12,  The most highly evidence indicates reduced form of vitamin methylcobalamin is utilized B12 possible more efficiently than cobalamin  Why Methylcobalamin?  Already metabolically Methylcobalamin doesnt active have to engage the bodys resources to convert it into  Maximally reduced coenzyme form  Less of a strain on our bodies antioxidant capacity Methylcobalmin is closely  4:1 allied with the folic acid biochemical pathway and promotes normal detoxification
    11. 11. Vitamin B3 (Niacin/Niacinamide) Food sources include:  A water-soluble vitamin  Beets, brewers yeast, beef necessary for numerous liver, beef kidney, pork, metabolic pathways in the turkey, chicken, veal, fish, body tuna, peanuts  Involved in pathways that sustain and renew the body’s tissues  10:1
    12. 12. Vitamin C Water-soluble vitamin, also  Cofactor for dopamine known as ascorbic acid production, helps maintain brain health Food sources include:  Vitamin C also promotes  Oranges, green peppers, glutathione levels, another strawberries, other fruit, important antioxidant in the tomatoes, broccoli body Promotes normal tissue  19:1 repair, bone healing, immune function among other things Proven antioxidant
    13. 13. Vitamin C A large study by James et al. confirmed low glutathione levels in children and associations with abnormalities in their methionine pathway, i.e. increased oxidative stress  153 children studied for transmethylation and transulfuration issue and 565 children evaluated for common polymorphic variants known to modulate these pathways  James et al. Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism. American Journal of Medical Genetics. 141B(8):947-56, 2006. Vitamin C supported red blood cell glutathione levels in college students  Johnston et al. Vitamin C elevates red blood cell glutathione in healthy adults. American Journal of Clinical Nutrition. 58(1):103-5, 1993.
    14. 14. Vitamin A (Beta-Carotene) Essential vitamin –  Powerful antioxidant  Beta-Carotene → retinal form of vitamin A → retinol  Vitamin A deficiency is Food sources include: commonly found in children  Yellow and orange fruits with neurological, metabolic (carrots, papaya. mangos), and digestive needs green leafy veggies (spinach)  19:1 Supports normal cell growth and differentiation, especially in tissues of the gut and brain, helps maintain vision and immune functions
    15. 15. Zinc Food sources include:  Copper imbalance in children  Oysters, red meat, beans, is also associated with delayed nuts, certain seafood, whole development, anti-social and grains hyperactive behavior, learning difficulties An essential mineral  Because zinc helps facilitate When zinc levels are down, the excretion of excess copper levels are often copper, it is important to make increased sure a multivitamin has an adequate amount of zinc Children who need neurological or digestive  Avoid copper-containing support often have an supplements abnormal zinc to copper ratio  22:1
    16. 16. Calcium Food sources include:  Calcium supplementation  Dairy, milk, yogurt, cheese, may help to promote green leafy vegetables normal oxalate absorption  Bind to dietary calcium and is removed through the This mineral promotes digestive tract and not normal: absorbed  bone health nerve transmission It’s especially important to    muscle contraction  vasodilation supplement calcium in  enzyme reactions those on a casein-free  respiration diet  among many others  14:1
    17. 17. Magnesium Food sources include:  Combination of B6 and  Green vegetables (spinach), magnesium legumes (beans and peas), nuts and seeds  4.6:1 and 11:1 (combination) Essential mineral Supports the proper functioning of many enzymes, including those responsible for the production of neurotransmitters in the brain
    18. 18. Recent Multivitamin Research A small pilot study found that a strong, balanced multi- vitamin/mineral supplement resulted in improvements in sleep and promoted normal gut function in children, and possibly in other areas  20 children ages 3-8 years old  Given a multivitamin/multimineral supplement for 3 months  Based on parental assessment, there were statistically significant improvements in sleep and supported GI comfort  Also determined a functional need for more vitamin B6 and vitamin C  Adams J et al. Pilot study of a moderate dose multivitamin/mineral supplement for children with autistic spectrum disorder. Journal of Alternative and Complementary Medicine. 10(6):1033-1039, 2004.
    19. 19. Conclusion• The need for increased support in the areas of neurology, metabolism and digestion is more prevalent in our society than ever before, but there are proven nutritional approaches that may help:  Recap of important ingredients:  Folinic acid  P5P (Vitamin B6)  Methylcobalamin  Vitamin C  Zinc  Calcium  Magnesium
    20. 20. Isotonix Might-a-Mins ® Spectrum Multivitamin  $54.95  FreeShipping 
    21. 21. Isotonix Might-a-Mins ® Spectrum Multivitamin Helps to promote normal levels of vitamins and minerals in individuals who need neurological, digestive or metabolic support Helps maintain the normal production of neurotransmitters Promotes/supports a healthy nervous system Helps maintain brain health Promotes a healthy development of sensory and communication skills.
    22. 22. Isotonix Might-a-Mins ® Spectrum Multivitamin Provides strong antioxidant defense Combats free radicals Promotes normal tissue and cell growth Provides nutrients essential for numerous processes in the body Supports optimal immune functions Supports skeletal health and growth Supports healthy teeth and gums Supports growth and strength of teeth and bones Supports cognitive health and development Supports healthy vision and eyes Supports a healthy heart
    23. 23. References Kidd P. Autism, an extreme challenge to integrative medicine. Part II: medical management. Alternative Medicine Review. 7(6):472-499, 2002. Adams J. Summary of Biomedical Treatments for Autism. Autism Research Institute Publication. 40 (April), 2007. Adams J et al. Pilot study of a moderate dose multivitamin/mineral supplement for children with autistic spectrum disorder. Journal of Alternative and Complementary Medicine. 10(6):1033-1039, 2004. Megson M. Is autism a G-alpha protein defect reversible with natural vitamin A? Medical Hypotheses. 54(6):979-983, 2000. Lelord G et al. Effects of pyridoxine and magnesium on autistic symptoms: initial observations. Journal of Autism Developmental Disorders. 11(2):219-229, 1981. Martineau J et al. Effects of vitamin B6 on averaged evoked potential in infantile autism. Biological Psychiatry. 16(7):627-641, 1981. Martineau J et al. Vitamin B6, magnesium, and combined B6-Mg: therapeutic effects in childhood autism. Biological Psychiatry. 20(5):467-478, 1985. Lonsdale D et al. Treatment of autism spectrum children with thiamine tetrahydrofurfuryl disulfide: A pilot study. Neuroendocrinology Letters. 23(4):303- 308, 2002. Rimland B et al. The effect of high doses of vitamin B6 on autistic children: a double-blind cross-over study. American Journal of Psychiatry. 135(4):472, 1978. Rimland B. Vitamin B6 (and magnesium) in the treatment of autism. Autism Research Review International. 1(4), 1987.
    24. 24. References Dolske M. et al. A preliminary trial of ascorbic acid as supplemental therapy for autism. Progress in Neuropsycho-pharmacology and Biological Psychiatry. 17(2):765-774, 1993. Rimland B. Vitamin C in the Prevention and Treatment of Autism. Autism Research Review International. 12:3, 1998. Martineau J et al. Brief report: an open middle-term study of combined vitamin B6- magnesium in a subgroup of autistic children selected on their sensitivity to this treatment.  Journal of Autism and Developmental Disorders. 18:435-447, 1988. Martineau J et al. Electrophysiological effects of fenfluramine or combined vitamin B6 and magnesium on children with autistic behavior. Developmental Medicine and Child Neurology. 31:728-736, 1989. Audhya T. (2002, October). Laboratory indices of vitamin and mineral deficiency in autism.  Paper presented at the Defeat Autism Now! Conference, San Diego, California. Angley M et al. Children and autism--Part 2--management with complementary medicines and dietary interventions. Australian Family Physician. 36(10):827-30, 2007. Levy S et al. Novel treatments for autistic spectrum disorders. Mental Retardation and Developmental Disabilities Research Reviews. 11(2):131-42, 2005. Review. Rimland B. Controversies in the treatment of autistic children: vitamin and drug therapy. Journal of Child Neurology. 3 Suppl:S68-72, 1988. Pfeiffer S et al. Efficacy of vitamin B6 and magnesium in the treatment of autism: a methodology review and summary of outcomes. Journal of Autism and Developmental Disorders. 25(5):481-93, 1995. Kleijnen J and Knipschild P. Niacin and vitamin B6 in mental functioning: a review of controlled trials in humans. Biological Psychiatry. 29(9):931-41, 1991.
    25. 25. References Kotsanis C et al. Autism – A multidisciplinary approach to treatment. Study Profile, DFW Ear, Nose & Throat Associates. Grapevine TX. No date given. Levy A and Hyman S. Use of complementary and alternative treatments for children with autistic spectrum disorders is increasing. Pediatric Annals. 32:685- 91, 2003. Werbach M. Nutritional treatments for autism - nutritional influences on illness. Townsend Letter for Doctors and Patients. October 2003. Autism Research Institute. Accessed May and June 2008. Osendarp S et al. Effect of a 12-mo micronutrient intervention on learning and memory in well-nourished and marginally nourished school-aged children: 2 parallel, randomized, placebo-controlled studies in Australia and Indonesia. American Journal of Clinical Nutrition. 86(4):1082-93, 2007. Mousain-Bosc M et al. Improvement of neurobehavioral disorders in children supplemented with magnesium-vitamin B6. Magnesium Research. 19(1):53-62, 2006. Moretti P et al. Cerebral folate deficiency with developmental delay, autism, and response to folinic acid. Neurology. 64(6):1088-90, 2005. Marlow M et al. Decreased magnesium in the hair of autistic children. Journal of Orthomolecular Psychiatry. 13(2):117-122, 1984.
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