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Pharmaceutical Cold chain Distribution
Pharmaceutical Cold chain Distribution
Pharmaceutical Cold chain Distribution
Pharmaceutical Cold chain Distribution
Pharmaceutical Cold chain Distribution
Pharmaceutical Cold chain Distribution
Pharmaceutical Cold chain Distribution
Pharmaceutical Cold chain Distribution
Pharmaceutical Cold chain Distribution
Pharmaceutical Cold chain Distribution
Pharmaceutical Cold chain Distribution
Pharmaceutical Cold chain Distribution
Pharmaceutical Cold chain Distribution
Pharmaceutical Cold chain Distribution
Pharmaceutical Cold chain Distribution
Pharmaceutical Cold chain Distribution
Pharmaceutical Cold chain Distribution
Pharmaceutical Cold chain Distribution
Pharmaceutical Cold chain Distribution
Pharmaceutical Cold chain Distribution
Pharmaceutical Cold chain Distribution
Pharmaceutical Cold chain Distribution
Pharmaceutical Cold chain Distribution
Pharmaceutical Cold chain Distribution
Pharmaceutical Cold chain Distribution
Pharmaceutical Cold chain Distribution
Pharmaceutical Cold chain Distribution
Pharmaceutical Cold chain Distribution
Pharmaceutical Cold chain Distribution
Pharmaceutical Cold chain Distribution
Pharmaceutical Cold chain Distribution
Pharmaceutical Cold chain Distribution
Pharmaceutical Cold chain Distribution
Pharmaceutical Cold chain Distribution
Pharmaceutical Cold chain Distribution
Pharmaceutical Cold chain Distribution
Pharmaceutical Cold chain Distribution
Pharmaceutical Cold chain Distribution
Pharmaceutical Cold chain Distribution
Pharmaceutical Cold chain Distribution
Pharmaceutical Cold chain Distribution
Pharmaceutical Cold chain Distribution
Pharmaceutical Cold chain Distribution
Pharmaceutical Cold chain Distribution
Pharmaceutical Cold chain Distribution
Pharmaceutical Cold chain Distribution
Pharmaceutical Cold chain Distribution
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Pharmaceutical Cold chain Distribution

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Pit-Stop express, innovation in distribution, pharmaceutical cold chain. Phase Change Material.

Pit-Stop express, innovation in distribution, pharmaceutical cold chain. Phase Change Material.

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  • Peltier Effect
  • Johns Hopkins Bloomberg School of Public Health
  • Transcript

    • 1. Pharmaceutical &
      Bio Cold Chain Conference - 2011
      Behind-The-Scene:Options for Bio Pharma Shipments
      by Capt. Pawanexh Kohli
      Founder, CrossTree techno-visors
    • 2. At 45,000 feet:10°F / -12 C
      ?
      • Ground transport for pick up.
      • 3. Airport loading/handling prior to departure.
      • 4. Air transport - Flight transfers.
      • 5. Airport arrival delay pending release.
      • 6. Ground transport for last leg delivery.
      • 7. Storage option for out of hour arrivals.
      Passive Cooling with safety Margin and
      Qualified packaging to counter extreme
      Ambient Temperature variations in transit.
      Mumbai
      90°F 32°
      Jaipur
      111°F 44°C
      Current Scenario
    • 8. The ChallengesAir mode
      Wide fluctuation in external ambient.
      Dynamic chain of custody.
      Transit time limited due to cold chain system.
      Routing limited via existing airports only.
      Contingency “Plan B” options limited.
      Volatility in air capacity and ATF.
    • 9. Typical Surface Network
      Uses feeder service to consolidate.
      Long haul with transit times extension.
      Optimised routing via various touch points.
      Door step delivery through last mile feeders.
      Low cost option, mixed load option.
    • 10. Surface ModeDistribution Network
    • 11. Surface ModeDistribution Network
      Operating Unit
    • 12. Surface ModeDistribution Network
      Pick-up Point
      Operating Unit
    • 13. Surface ModeDistribution Network
      Pick-up Point
      Operating Unit
    • 14. Surface ModeDistribution Network
      Pick-up Point
      Distribution Centre
      Operating Unit
    • 15. Surface ModeDistribution Network
      Feeder System
      Pick-up Point
      Distribution Centre
      Operating Unit
    • 16. Express Distribution Centre
      Pick-up
      Feeder
      Operating Unit
      Surface ModeDistribution Network
    • 17. OR
      Express Distribution Centre
      OU
      Feeder
      Pick-up
      Feeder
      Operating Unit
      EDC
      Surface ModeDistribution Network
    • 18. OR
      Express Distribution Centre
      Express Connection
      OU
      Feeder
      Pick-up
      Feeder
      Operating Unit
      EDC
      Surface ModeDistribution Network
    • 19. OR
      Express Distribution Centre
      Express Connection
      OU
      Feeder
      Pick-up
      Feeder
      Operating Unit
      EDC
      Surface ModeDistribution Network
    • 20. OR
      Express Distribution Centre
      Express Connection
      OU
      Feeder
      Pick-up
      Feeder
      Networked / Tracked
      Operating Unit
      EDC
      Surface ModeDistribution Network
    • 21. OR
      Express Distribution Centre
      Express Connection
      OU
      Feeder
      Pick-up
      Feeder
      Networked / Tracked
      Operating Unit
      EDC
      Surface ModeDistribution Network
    • 22. Spoke
      Origin - Destination
      HUB
      HUB
      Spoke
      Destination
      Origin
      Spoke
      Networked / Tracked
      HUB
      HUB
      Spoke
      Spoke
      Spoke
      Spoke
      Networked / Tracked
      Spoke
      Surface ModeDistribution Network
    • 23. Advantage Surface Network
      Allows Inclusive logistics in future plant and distribution site planning
      Superior planning of service expansions 
      Establish Quality Agreements between custodial stakeholders
      Limits potential for a logistics logjam and a storage nightmare.
    • 24. Upping the Ante
      It’s not just about developing safe and effective vaccines....
      It’s about getting vaccines to the right place, at the right time, in the right condition.....
      and...that means delivery systems that are as advanced & innovative as the vaccines they support.
    • 25. ‘Pit-Stop’ ExpressRight Cost Solution
    • 26. Pit-Stop Process
      Pickup Point
      Dispatch OU
    • 27. Pit-Stop Process
      Pickup Point
      Dispatch OU
      Enroute Touch Point
    • 28. Pit-Stop Process
      Pickup Point
      Dispatch OU
      Enroute Touch Point
      Waiting/Cooling
    • 29. Pit-Stop Process
      Pickup Point
      Dispatch OU
      Enroute Touch Point
      Waiting/Cooling
      Re-Charge Needed?
    • 30. Pit-Stop Process
      Pickup Point
      Dispatch OU
      Enroute Touch Point
      Waiting/Cooling
      Re-Charge Needed?
      YES
    • 31. Pit-Stop Process
      Pickup Point
      Onward Transit
      Dispatch OU
      Seal Shipper
      Enroute Touch Point
      Replace Chill Packs
      Waiting/Cooling
      Open Shipper
      Re-Charge Needed?
      YES
    • 32. Pit-Stop Process
      Pickup Point
      Onward Transit
      Dispatch OU
      Seal Shipper
      Enroute Touch Point
      Replace Chill Packs
      Waiting/Cooling
      Open Shipper
      Re-Charge Needed?
      YES
    • 33. Pit-Stop Process
      Pickup Point
      Onward Transit
      Dispatch OU
      Seal Shipper
      Enroute Touch Point
      Replace Chill Packs
      Waiting/Cooling
      Open Shipper
      Re-Charge Needed?
      NO
      YES
    • 34. Pit-Stop Process
      Pickup Point
      Onward Transit
      Dispatch OU
      Seal Shipper
      Enroute Touch Point
      Replace Chill Packs
      Waiting/Cooling
      Open Shipper
      Re-Charge Needed?
      Onward Transit
      Receiving OU
      Customer Out Reach Point
      NO
      YES
    • 35. Pit-Stop Process
      Pickup Point
      Onward Transit
      Dispatch OU
      Seal Shipper
      Enroute Touch Point
      Replace Chill Packs
      Waiting/Cooling
      Open Shipper
      Re-Charge Needed?
      Onward Transit
      Receiving OU
      Pit-Stop
      Customer Out Reach Point
      NO
      YES
    • 36. Pit-Stop Process
      Pickup Point
      Onward Transit
      Replace
      • Shipper Chill Packs
      • 37. Shipper Outer Seal
      Dispatch OU
      Seal Shipper
      Enroute Touch Point
      Replace Chill Packs
      Waiting/Cooling
      Open Shipper
      Re-Charge Needed?
      Onward Transit
      Receiving OU
      Pit-Stop
      Customer Out Reach Point
      NO
      YES
    • 38. Pit-Stop Process
      Pickup Point
      Onward Transit
      Replace
      • Shipper Chill Packs
      • 39. Shipper Outer Seal
      Dispatch OU
      Seal Shipper
      Enroute Touch Point
      Replace Chill Packs
      Record
      • Shipper Contents
      • 40. Pit-stop Checklist
      Waiting/Cooling
      Open Shipper
      Re-Charge Needed?
      Onward Transit
      Receiving OU
      Pit-Stop
      Customer Out Reach Point
      NO
      YES
    • 41. Pit-Stop Process
      Pickup Point
      Onward Transit
      Replace
      • Shipper Chill Packs
      • 42. Shipper Outer Seal
      Dispatch OU
      Seal Shipper
      Enroute Touch Point
      Replace Chill Packs
      Record
      • Shipper Contents
      • 43. Pit-stop Checklist
      Waiting/Cooling
      Open Shipper
      Re-Charge Needed?
      • Cargo Onward
      • 44. Recharge Chill Packs
      Dispatch
      Onward Transit
      Receiving OU
      Pit-Stop
      Customer Out Reach Point
      NO
      YES
    • 45. Value added - Advantages
      Multi-modal and risk managed movement.
      More consistent ambient exposure; reduced risk.
      Tight chain of custody, enhanced traceability.
      Trained experienced operators – SOPs & GDP.
      Option to store off-site, shorter lead time to market.
      Single source shipping & tracking solutionprovider.
      Optimise the transport mode; right cost distribution.
      Ahead in reach to remote markets; increase capture.
      Min/max or Online monitoring options.
      Improved contingency planning & assured options.
    • 46.
      • Centrally located hub function
      • 47. Multi Modal Connectivity
      • 48. Documentation and routing
      • 49. Consolidation of handling
      • 50. Air Express for fast track.
      • 51. ‘Pit-Stop’ Express: Surface mode
      • 52. Milk-run Express: Reefer Fleet.
      • 53. Active cooled Boxes remote loads
      • 54. Optimised Routing, multi-modal options.
      • 55. Both innovative & conventional modes.
      • 56. Single connected Chain of Custody.
      • 57. Brand Assurance and Quality Assurance.
      • 58. Life cycle Management.
      Bio-Pharma ExpressMulti-modal
    • 59. Bio-Pharma ExpressMulti-modal
      First level bulk evacuation from Production unit to a cold storage Facility.
      Break Bulk facility for onward dispatch per demand pull.
      Dispatch to receivers; optimise modes of transport:
      via Air only for urgent shipments.
      via Surface with Ice Bank replenishments; ‘Pit-stops’.
      via Surface using mobile reefer boxes; Active boxes.
      Via Reefer Fleet; Milk-run or Point to Point.
      Delivery direct to stockist premise.
      Demand mapping and forecasting.
      Unified chain of custody in total supply chain.
      Direct access storage for all pan-India orders.
      Inventory management through product’s life cycle.
    • 60. Pharma Industry
      Volumetric growth in last decade including Bio-pharma
      Implications
      Storage:
      Greatly increased need for +2°C to + 8°C storage.
      Storing and handling vaccines in secondary packaging will become increasingly impractical.
      Move towards palletized storage.
      Distribution:
      Move towards bulk distribution containers or refrigerated trucks.
      Management:
      Strengthen logistics management and QA procedures.
    • 61. Pharma Talk
      Need for Change in Packing
      Introduce an un-insulated tertiary pack:
      Insulated shipping containers take up too much space (Bulking factor 3.5 to 7.5 times secondary packaging).
      Existing secondary packs are too small for mechanical handling at primary level.
      Therefore: Some form of tertiary packaging is needed:
      A carton containing multiple secondary packs, ideal.
      Shrink-wrapped secondary pack not robust enough.
    • 62. Distribution technology
      First stage distribution:
      Traditional cold boxes will be phased out.
      Refrigerated trucks may be OK in countrieswith good infrastructure and good roads.
      But insulated passive bulk containers will solve the problem in many settings.
      Other implications:
      PCM / chilled packs will require refrigeration.
      Larger pallet-enabled delivery vehicles will be required.
      Tail lifts and/or dock levellers will be needed.
    • 63. Associated operational changes
      Order picking at primary level:
      Wherever possible orders will be picked in large packs. Bulk breaking will be minimized.
      Orders pre-assembled into passive containers and kept inside the cold room until the delivery date.
      Packed crates/cartons may be bar-coded to assist with order tracking down to intermediate store level.
      Inventory Management:
      Stock in pallet stores cannot readily be inspected. Professionally developed and supported inventory control software, with accurate pallet location data will be essential.
    • 64. Components of latent heat storage
      Energy cannot be destroyed or created
      – it can only change from one form to another.
    • 65. Energy to Change Phase
      • Heat of Fusion
      • 66. Make/Break Molecular Bonding.
      • 67. Solid to Liquid – Endothermic
      • 68. Absorbs Energy (Heat).
      • 69. Liquid to Solid – Exothermic
      • 70. Releases Energy (Heat).
      In case of Melting Ice: the ice-water mix remains at 0 ºC until all phase change completes
    • 71. How/What PCM?Harnessing the Force of the Molecule
      Four Phases of Matter.
      (4th phase is plasma – atomic forces)
      Control the temperature zone when a material makes or breaks the Molecular Force of attraction.
      PCM can be Organic and synthetic mixtures.
      Is a method to store energy at differing desired levels.
    • 72. Thermal Inertia
      • The tendency to retain or resist any energy level change.
      • 73. Maintains a desired steady state temperature profile.
      • 74. Energy stored and output from 170 KJ to 300 KJ per kg.
      • 75. Offers a wide array of thermal applications.
      When water freezes, energy is released to surroundings.
      When ice melts, energy is absorbed from surroundings.
      PCM is like ‘ICE’ at controlled, desired temperature levels (example: ice that melts at +20 ºC)
    • 76. Other Innovation
    • 77. Actively Cooled or
      Passive Cooled
      inner city distribution
      Other Innovation
      Active Boxes
    • 78. Thank You
      Fini
      “An ideal supply chain is one that ensures that the limits of science are not constrained by the limits of systems.” — Dr Orin Levine

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