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Protein
Synthesis
By Blake Bizousky
Cytoplasm

-Ribosomes
Cytoplasm

-Ribosomes
Cytoplasm

-Ribosomes
~~~~~~~~~T A C T T A G C G T A G A T T~~~~~~~~~~
I I I I I I I I I I I I I I I
I I I I I I I I I I I I I I I
~~~~~~~~~A T G A A T C G C A T C T A A~~~~~~~~~~

-Ribosomes
Nucleus

~~~~~~~~~T A C T T A G C G T A G A T T~~~~~~~~~~
I I I I I I I I I I I I I I I
I I I I I I I I I I I I I I I
~~~~~~~~~A T G A A T C G C A T C T A A~~~~~~~~~~

-Ribosomes
Nucleus

~~~~~~~~~T A C T T A G C G T A G A T T~~~~~~~~~~

~~~~~~~~~A T G A A T C G C A T C T A A~~~~~~~~~~
DNA
Molecule

-Ribosomes
Nucleus

~~~~~~~~~T A C T T A G C G T A G A T T~~~~~~~~~~

~~~~~~~~~A T G A A T C G C A T C T A A~~~~~~~~~~
RNA
Polymerase

DNA
Molecule

-Ribosomes
Nucleus

~~~~~~~~~T A C T T A G C G T A G A T T~~~~~~~~~~

~~~~~~~~~A T G A A T C G C A T C T A A~~~~~~~~~~
RNA
Polymerase

DNA
Molecule

-Ribosomes
Nucleus

~~~~~~~~~T A C T T A G C G T A G A T T~~~~~~~~~~

~~~~~~~~~A T G A A T C G C A T C T A A~~~~~~~~~~
RNA
Polymerase

DNA
Molecule

-Ribosomes
Nucleus

~~~~~~~~~T A C T T A G C G T A G A T T~~~~~~~~~~

~~~~~~~~~A T G A A T C G C A T C T A A~~~~~~~~~~
RNA
Polymerase

DNA
Molecule

-Ribosomes
Nucleus

~~~~~~~~~T A C T T A G C G T A G A T T~~~~~~~~~~

~~~~~~~~~A T G A A T C G C A T C T A A~~~~~~~~~~
DNA
Molecule

-Ribosomes
Nucleus

~~~~~~~~~T A C T T A G C G T A G A T T~~~~~~~~~~

~~~~~~~~~A T G A A T C G C A T C T A A~~~~~~~~~~
DNA
Molecule

-Ribosomes
Nucleus
mRNA Strand

~~~~~~~~~T A C T T A G C G T A G A T T~~~~~~~~~~

~~~~~~~~~A T G A A T C G C A T C T A A~~~~~~~~~~

-Ribosomes
Nucleus
mRNA Strand

~~~~~~~~~T A C T T A G C G T A G A T T~~~~~~~~~~

~~~~~~~~~A T G A A T C G C A T C T A A~~~~~~~~~~

-Ribosomes
Nucleus

mRNA Strand
Nuclear
Pore

~~~~~~~~~T A C T T A G C G T A G A T T~~~~~~~~~~

~~~~~~~~~A T G A A T C G C A T C T A A~~~~~~~~~~
DNA
Molecule

-Ribosomes
Nucleus
mRNA Strand

Nuclear
Pore

~~~~~~~~~T A C T T A G C G T A G A T T~~~~~~~~~~

~~~~~~~~~A T G A A T C G C A T C T A A~~~~~~~~~~
DNA
Molecule

-Ribosomes
Nucleus
Nuclear
Pore
~~~~~~~~~T A C T T A G C G T A G A T T~~~~~~~~~~

~~~~~~~~~A T G A A T C G C A T C T A A~~~~~~~~~~
DNA
Molecule

-Ribosomes
Nucleus
Nuclear
Pore
~~~~~~~~~T A C T T A G C G T A G A T T~~~~~~~~~~

~~~~~~~~~A T G A A T C G C A T C T A A~~~~~~~~~~
DNA
Molecule

-Ribosomes
Nucleus
Nuclear
Pore
~~~~~~~~~T A C T T A G C G T A G A T T~~~~~~~~~~

~~~~~~~~~A T G A A T C G C A T C T A A~~~~~~~~~~
DNA
Molecule

-Ribosomes
Cytoplasm
Ribosome

Large unit

AUG

A AU

CGC

Small unit
Start
Condon

Codon
Ribosome

U AC

Large unit

AUG

A AU

CGC

Small unit
Start
Condon

Codon
Ribosome

Large unit

U AC

AUG

A AU

CGC

Small unit
Start
Condon

Codon
Amino acid

Ribosome

tRNA
Molecule

Large unit

Anticodon

U AC
AUG

A AU

CGC

Small unit
Start
Condon

Codon

AUC

U
Amino acid

Ribosome

tRNA
Molecule

Large unit

UU A
Anticodon

U AC
AUG

A AU

CGC

Small unit
Start
Condon

Codon

AUC

U
Amino acid

Ribosome

tRNA
Molecule

Large unit

Anticodon

UU A

U AC
AUG

A AU

CGC

Small unit
Start
Condon

Codon

AUC

U
Peptide bond

U AC

UU A

AUG

A AU

Start
Condon

CGC

Codon

AUC

UAA
Peptide bond

GC G

UU A
AUG

Start
Condon

A AU

CGC

Codon

AUC

UAA
Peptide bond

UU A
AUG

Start
Condon

A AU

GC G
CGC

Codon

AUC

UAA
Peptide bond

U U A GC G
AUG

A AU

CGC

Codon

AUC

UAA
UAG
GC G
AUG

A AU

CGC

Codon

AUC

UAA
GC G
AUG

A AU

UAG

CGC

AUC

Codon

UAA
A AU

GC G

UAG

CGC

AUC

UAA

Stop Codon
Codon
A AU

UAG
CGC

AUC

UAA

Stop Codon
Codon
GC

on

AUC

UAA

Stop Codon
C

UAA

Stop Codon
Amino acid in
tertiary
structure
Protein synthesis begins with transcription inside the nucleus. During
transcription RNA polymerase binds to the DNA molecule at the promoter region
and copies the coding region. RNA polymerase makes a single stranded mRNA copy
of the DNA. RNA polymerase then stops copying at the terminating sequence and
the mRNA strand makes it way out of the nucleus through a nuclear pore. Now in the
cytoplasm, the mRNA strand binds with a ribosome. The ribosomes start reading the
mRNA strand at the start codon. The ribosome brings in the correct anti-codon on a
tRNA molecule which carries the certain amino acids which the codon coded for. The
ribosome then brings in the rest of the tRNA. Between the tRNA molecules the
amino acids form a peptide bond between each other. The tRNA then falls
off, leaving the amino acid with the one which it bonded with. When the ribosomes
has made it through all the codons it will reach the end codon. The end codon tells
the ribosome to stop bringing in tRNA molecules. The polypeptide left behind now
folds up into it’s tertiary form as a protein and goes on to do its function in the cell.

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