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According to new research, the cosmetic application of Botox seems to lower symptoms of depression in some patients, possibly because it inhibits frowning. Previous research has demonstrated that physically expressing an emotion first can trigger subsequent feelings and that people who laugh or smile regularly can improve their mood. Studies have also shown that people find jokes funnier when a pencil is placed between their teeth lengthwise, which forces a smile, than when they hold it pointing outwards, which doesn’t. This is the second study to compare Botox to placebo. Although the results have not yet been thoroughly reviewed enough for publication in a scientific journal, the findings suggest that it may hold promise.