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Target research to determine the effect of tobacco cigarette industry waste vermicompost on the growth and production of Cucumis melo L Red Aroma varieties. Randomized block design (RBD) research methods repeated three times with 4 treatments: S1 = vermicompost dose of 1000 kg / ha; S2 = vermicompost dose of 2000 kg / ha; S3 = vermicompost dose of 3000 kg / ha; S4 = vermicompost dose of 4000 Kg / ha, plus S0 = control without treatment vermicompost; observation variable length of plants, number of leaves, leaf area, fruit weight per fruit, fruit volume and fruit brix; statistically analyzed with ANOVA F test. Tools used, meter, scales and refractometer. Materials used vermicompost tobacco waste, Aroma Red Cucumis melo seed varieties. The results turned out tobacco cigarette factory waste can be used as organic fertilizer. It is shown to affect the growth and yield of Cucumis melo L Red Aroma Varieties, namely: plant length, number of leaves, leaf area, fruit weight, fruit volume and sugar content in fruit.