Presentation of Capabilities and Competitive Advantage of Neuromics' umbilical derived human stem cells and MSCGro high performance growth and differentiation media.
H ms cs_capabilities_competitive_analysis_ 7-11-12
1. Potent Human Mesenchymal Stem Cells and Media
Capabilities and Competitive Analysis
www.neuromics.com
2. STEM CELL PRODUCTS
Focus on Mesenchymal Stem Cells-Why MSCs?
• Numerous Clinical Uses:
Joint disease & injury, autoimmunity, stroke, organ failure (heart,
liver, kidney & lung), MS, promotion of HSC engraftment,
regenerative medicine, cancer, hearing loss, etc.
• Readily Available:
Blood, adipose (fat) tissue, bone marrow, teeth, etc
3. GFP-Expressing Human MSCs Catalog Number SC00A4
Image: FITC of Single Human MSC GFP-Expressing Human MSCs
express label in the cytoplasm.
Illustrates morphological detail of human mesenchymal stem cells.
5. Red Fluorescent Human Mesenchymal Stem Cells
Self-Renewal Transfer of label to
chondrocyte (25 mM
PGE2)
6. MSC Growth in Low Serum MSCGro™ Compared to Lonza MSC-GM
MSCGroTM at Day 3 MSCGroTM at Day 4
Lonza at Day 3 Lonza at Day 4
7. Human MSC Growth in MSCGroTM vs Competitors Media:
MSCGroTM results in faster growth & 2-3-fold greater cell recovery
8. 160
Real Time Stability of MSCGro
140 Compared to Competitor's Medium
120
Doubling Time (Hrs)
100 MSCGro at 5% O2
MSCM-ScienCell at 5% O2
80
MSCGro at 20% O2
60 (Adipose MSCs by third party)
40
20
0
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14
o
Months at 2-8 C
10. Differentiation of Human MSCs Cultured in MSC-GroTM Medium
Chondrocyte Stained Adipocytes Stained with Osteoblast Stained
with Alcian Blue Oil Red with Alizarin Red
11. Competitive Advantages of MSCGroTM
• MSC growth rate/cell recovery > Lonza, InVitrogen, Stem Cell
Technologies, ScienCell & ZenBio media.
• MSC quality/potency (Lumenesc™) > Lonza, InVitrogen and Stem Cell
Technologies media.
• Vastly improved real time stability.
• Medium function unaffected by freezing.
• Out-performs competitors at both reduced & ambient O2
• Supports self-renewal of human, rat & mouse MSCs
• Also supports primary cultures: fibroblasts (human & rat); rat
cardiomyocytes & possibly hepatocytes
• Provided complete & ready to use as is.