Prostate Cancer Institute presentation

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Prostate Cancer Institute, NUI Galway

Presentation on Prostate Cancer Institute

Health & Medicine

Prostate Cancer Institute Report to NUIG Foundation 15 th December 2010

Prostate cancer incidence 2004-2006 by County

New and suspected prostate cancer cases seen by hospital Ireland 2006 - 2007 1.4:1 150 Unknown 107 105 Waterford 3:1 1100 820 365 272 UCHG 2:1 335 Unknown 180 Unknown St Vincent’s 2.6:1 280 Unknown 105 101 St James’ 1.6:1 274 304 171 145 MUH 5:1 (est) 1200(est) 1000 (estimate) 240 220 Mater 3:1 311 301 104 112 Limerick Regional 2:1 382 340 210 186 CUH 2.5:1 453 530 179 151 Beaumont 2.5:1 676 797 273 327 AMNCH Benign: malignant ratio 2007 Suspected prostate cancer cases seen in 2007 Suspected prostate cancer cases seen in 2006 New prostate cancer cases diagnosed in 2007 New prostate cancer cases diagnosed in 2006 Hospital

Critical Mass of Key Components Significant basic science ongoing NUIG/ PRTLI Translational Research Facilities Clinical Research Facilities Clinical Resources Patients Galway University and GUH NUIG Foundation Prostate Cancer Institute Strategic partners

Strategic research partners CRF/TRF REMEDI PCI NCBRI

Institute governance model Prostate Cancer Institute Medical Advisory Panel Strategic Advisory Panel Scientific Advisory Panel Constituent NUIG

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According to the World Health Organization (WHO) prostate cancer is the second cause of cancer death in men worldwide [1,2]. Some advanced prostate cancers have well known symptoms. However non-cancerous diseases of the prostate, such as benign prostatic hyperplasia (BPH) cause same symptoms. On the other hand, at very early stages, prostate cancer has no symptoms, the tumor dimension is quite small, and it is extremely difficult to detect it. If prostate cancer is detected at an early stage, it can be successfully cured by different methods. At the later stages, treatment or surgery has very low efficiency. Prostate cancer can often be found by measuring the amount of PSA in the blood. Most healthy men have levels under 4 nano-grams per milliliter (ng/mL) of blood. When prostate cancer develops, the PSA level usually goes above 4. However, for determination of the existence of cancer, some additional methods are used: for example: PSA velocity [3,4] and/or PSA density. Besides, measurement of the ratio of free to total PSA is additional tool in prostate cancer diagnosis [5]. However, the major drawback of PSA determination is its relative lack of specificity. The PSA level can also be increased by benign prostate hyperplasia (BPH) - a noncancerous enlargement of the prostate, prostatitis, etc.

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