Dr Pratyush Chaudhuri
 
 
 
Drug Dose Route Aspirin 500-650 mg Oral Paracetamol 500 mg-4 g  Oral  Ibuprofen  200- 300 mg Oral Diclofenac 50-100 mg Ora...
Drug Dose Route Ergot alkaloids Ergotamine 1-2 mg/d; max-6 g/d Oral Dihydroergotamine 0.75-1 mg SC 5-HT receptor   agonist...
Drug  Dose (mg)/d Route Domperidone 10-80 mg Oral Metoclopramide 5-10 mg Oral/IV Promethazine 50-125 mg Oral/IM Chlorproma...
 
 
 
Drugs Dose (mg/d) <ul><li>Betablockers </li></ul><ul><ul><li>Propranolol (ciplar, betacap) </li></ul></ul>40-320 <ul><li>C...
Drugs Dose (mg/d) <ul><li>Anti-convulsant </li></ul><ul><ul><li>Sodium valproate </li></ul></ul>600-1200 <ul><li>Anti-hist...
 
 
 
 
 
 
Cephalalgia 1990; 10: 101-105 *p < 0.001 Variable Placebo (run in) Propranolol-LA 160 Propranolol-LA 80 Frequency (per mon...
Headache 1998; 28: 607-611 Parameter Baseline End-period Severity score 11.1 6.7*
 
48 50 0 10 20 30 40 50 60 70 Flunarizine (p<0.01) Propranolol (p<0.0005) No. of attacks reduced by more than 50% % of Pati...
1.6 1.6 1.4 1.2* 0 0.2 0.4 0.6 0.8 1 1.2 1.4 1.6 1.8 Flunarizine Propranolol Severity score Baseline 16 weeks * p<0.05 Hea...
 
 
 
 
 
That’s all folks!
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Neuro clinics 35 migraine 2

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Neuro clinics 35 migraine 2

  1. 2. Dr Pratyush Chaudhuri
  2. 6. Drug Dose Route Aspirin 500-650 mg Oral Paracetamol 500 mg-4 g Oral Ibuprofen 200- 300 mg Oral Diclofenac 50-100 mg Oral/IM Naproxen 500-750 mg Oral
  3. 7. Drug Dose Route Ergot alkaloids Ergotamine 1-2 mg/d; max-6 g/d Oral Dihydroergotamine 0.75-1 mg SC 5-HT receptor agonists Sumatriptan 25-300 mg 6 mg Orally SC Rizatriptan Naratriptan 10 mg 1mg, 2.5mg Orally orally
  4. 8. Drug Dose (mg)/d Route Domperidone 10-80 mg Oral Metoclopramide 5-10 mg Oral/IV Promethazine 50-125 mg Oral/IM Chlorpromazine 10-25 mg Oral/IV
  5. 12. Drugs Dose (mg/d) <ul><li>Betablockers </li></ul><ul><ul><li>Propranolol (ciplar, betacap) </li></ul></ul>40-320 <ul><li>Calcium Channel Blockers </li></ul><ul><ul><li>Flunarizine (sibelium) </li></ul></ul><ul><ul><li>Verapamil (Calaptin) </li></ul></ul>10-20 120-480 <ul><li>TCAs </li></ul><ul><ul><li>Amitriptyline (Libotryp) </li></ul></ul>10-20 <ul><li>SSRIs </li></ul><ul><ul><li>Fluoxetine </li></ul></ul>20-60
  6. 13. Drugs Dose (mg/d) <ul><li>Anti-convulsant </li></ul><ul><ul><li>Sodium valproate </li></ul></ul>600-1200 <ul><li>Anti-histaminic </li></ul><ul><ul><li>Cyproheptadine </li></ul></ul>4-8
  7. 20. Cephalalgia 1990; 10: 101-105 *p < 0.001 Variable Placebo (run in) Propranolol-LA 160 Propranolol-LA 80 Frequency (per month) 6.1 3.4* 3.9* Side effects n = 27 n = 18
  8. 21. Headache 1998; 28: 607-611 Parameter Baseline End-period Severity score 11.1 6.7*
  9. 23. 48 50 0 10 20 30 40 50 60 70 Flunarizine (p<0.01) Propranolol (p<0.0005) No. of attacks reduced by more than 50% % of Patients Headache 1989; 29: 218-223
  10. 24. 1.6 1.6 1.4 1.2* 0 0.2 0.4 0.6 0.8 1 1.2 1.4 1.6 1.8 Flunarizine Propranolol Severity score Baseline 16 weeks * p<0.05 Headache 1989; 29: 218-223
  11. 30. That’s all folks!
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