Prathiba Portfolio 2010

CURRICULUM VITAEName: PRATHIBA CHANDRASEKARANAddress: 110, Grant Ave, East Newark, NJ 07029, USA.Phone: +1 (973)-368-5029Email: cprathiba.iyer@gmail.com / pc223@njit.eduEducation • M.S (Biomedical Engineering) New Jersey Institute of Technology, USA Jan 2012 • B.E (Medical Electronics) Visveswaraya Technological University, India May 2010

TECHNICAL EXPERTISE• TOOLS: MATLAB, Pro-E, CAD, ANSYS, Minitab, Kiel µVision, Xilinx ISE Simulator, Corel Draw, SAS, Statistical Parametric Mapping (SPM), MriCron, pSpice.• PROGRAMMING LANGUAGES: C, C++, µP & µC ALP.• DESCRIPTOR LANGUAGES: VHDL, Verilog• SCRIPTING LANGUAGES: HTML, PHP• DATABASE: MySQL.• MICROSOFT SOFTWARE: Project, Visio, Data Analysis using Excel; Word and Power point.• LANGUAGES KNOWN: English, French, Hindi, Tamil, Kannada.

PROJECT WORK

DESIGN OF ORTHOPEDIC IMPLANTS NEW JERSEY INSTITUTE OF TECHNOLOGY

TOTAL HIP SYSTEM IMPLANTDesigned a Total Hip System Implant • Design Considerations: to restore effective kinematics with minimal/negligible damage to collateral structures without over constrain. Long term performance • Design Inputs: Tapered Stem, larger head without liner & hemispherical cup with grooves (to press fit as far as possible)

Designed using Pro-E.

KNEE IMPLANT• Design Goals: to restore mechanical alignment; soft- tissue balance with ligament and Patella tracking• Design Inputs: Polycurvature, Posterior stability. Range of Motion: Moves in all three planes – healthy joint offers 135o degree of flexion, for daily activities - 95 o degree of flexion• Performed Finite Element Analysis (FEA) and tested for Worst-case scenarios using Pro-E.

Lateral Cut & Box Cut Anterior Cut FilletedIntercondylar Notch, Patella Tracking and Grooves Component

Bone Cut out ProcessResults before Rounding Results after Rounding

CAPSTONE DESIGN PROJECTRESEARCH & INDUSTRY INCUBATION CENTER, DSCE, BANGALORE, INDIA

NON-INVASIVEBLOOD GLUCOSE MEASUREMENT

NON-INVASIVE MEASUREMENT OF BLOOD GLUCOSE • Goal: to develop a device to non-invasively measure blood glucose levels and interface with GSM modem and Infusion pump to form a feedback drug-delivery system. • Current techniques involves pricking of finger - is invasive, painful and cumbersome. • Device Features: • Use of Infra-Red Light Emitting Diodes (LED) for non-invasive measurement • Interface with GSM to send alarm signal to doctor • Interface with Infusion Pump to form feedback drug delivery system.

BLOCK DIAGRAM

NON-INVASIVE GLUCOSE SENSOR

INTERFACE WITH GSM AND INFUSION PUMP

PROCESS• Blood glucose level measured non-invasively in the finger.• Glucometer circuit detection (glucose level)• Given to PIC (acts as GSM) and a computer (doctor)• Received dialogue box displaying blood glucose level (along with patient’s data)• Dosage to restore normalcy by running infusion pump (motors)

ACADEMIC PROJECTSNEW JERSEY INSTITUTE OF TECHNOLOGY

BIOROBOTICS

BUILDING A ROBOT• Designed a wrist joint and built a 6DOF robot, conforming to Pieper’s Law using a MATLAB simulated toolbox – Simulink 3D.• This project demonstrates the definitions of positions & orientations of frames of references in terms of other frames of references using Transformation Matrixes .

ROBOT-ASSISTED SURGERY • Performed an automated surgery on a hot dog. • Used a MATLAB graphical toolbox to improve the graphical rendition of the robot model. • Robot is designed in order to easily compute its inverse kinematics and joint angles to achieve ideal and different positions and orientations • The Puma560 is used as reference.

ROBOT-ASSISTED SURGERY

TELEMANIPULATION• Wrote a MATLAB code to remotely control the robot with the help of ‘Flock of Birds’ – FOB.

BIO-MICRO-ELECTRO-MECHANICAL SYSTEMS (BIO-MEMS)

ANALYSIS OF MICRO-CANTILEVER • Resonant frequency, expected displacement, stresses and change in resonant frequency for a tip mass load was calculated using ANSYS and compared to theoretically obtained values. • Advantages: Higher sensitivity, low cost and analyte requirement and quicker response.Z component of Von Misses Stress Elastic Strain Modal Solutiondisplacement – top view

ANALYSIS OF MICRO-FLUIDIC CHANNEL• For channel and well configuration, relation between well dimensions, flow and velocity profile of liquid in the channel were analyzed and studied using ANSYS.• This can be helpful in diagnosing various conditions like anemia, where the viscosity of blood decreases due to decrease in packed cell volume.• Both single well and multi-well channels are taken into consideration.

Nodal Solution for Fluid Predefined Vector Plot Velocity Profile alongVelocity center line

PHYSIOLOGICAL MEASUREMENTS MEDICAL INSTRUMENTATION

EEG CIRCUIT TO DETECT Α AND Β WAVE ACTIVITY • Goal : Conceptually investigate and design an EEG circuit to monitor α and β wave activity using a bipolar configuration between O1 and O2 lead positions. • Design Features • Pre-amplifier circuit: to cure noise pick-up problem • Implementation of a differential amplifier • Usage of a band pass filter to effectively pass only α and β waves (8 – 30 Hz) • Inclusion on isolation amplifier for patient safety considerations

BLOCK DIAGRAM & REPRESENTATION

MEDICAL DEVICE DEVELOPMENT• Assembled a rudimentary Design History File (DHF) representing basic facets of medical device development. I was the Regulatory Affairs lead for my team. Key Role: Decide on regulatory pathway for a project proposal and write a regulatory rationale. Learnt about the 510(k) process and PMA.

REGULATORY AFFAIRS & VALIDATION • Conducted a URS survey and created a basic URS to qualify an environmental chamber. • Wrote IQ, OQ and PQ protocols for the environmental chamber • Wrote IQ, OQ, PQ test scripts for the environmental chamber • Performed a 21 CFR Part 11 quality audit – Risk Assessment, for a given vendor check list • Reviewed and presented various case studies on incidental company regulatory deviations and improving GLP, GCP and GMP compliance. • Acquired working knowledge of 21CFR 820, 200 and 300 series.

FUNCTIONAL MAGNETIC RESONANCE IMAGING (FMRI)• Performed Statistical Parametric Mapping using SPM8 to determine levels of activations based on the intensity of voxels, on given images.• Basically analyzed data by removing various factors such as scanner noise, head motion and mapping anatomical to functional images. This is done in 3 stages: • Spatial Pre-processing • Model specification, Review and estimation • Inference• Also made use of MriCron to show activations according to Z-scores.

Images showing increased activity in Brodmann areas 41 and 42 Design Matrix ImageImage Smoothening Movement relatedCoregistration & effects & data modelSegmentation representation

INTERN PROJECTSST.JOHN’S NATIONAL ACADEMY OF HEALTH SCIENCES, BANGALORE, INDIA.

Pulse Oxymeter Designed a circuit to measure blood oxygenation by sensing infrared and red light absorption properties of deoxygenated and oxygenated Haemoglobin. Circuit designed using Transimpedance amplifiers, Operational Amplifiers, Photo diodes and LED’s. LED – to shine visible red and infrared light into the earlobe or finger. Photo diode amplifiers – for light-to- voltage conversion. Switched Integrators – to cancel out thermal noise from feedback resistors.

Designed and built a seismic sensorwhich could sense any minute Seismic Sensorvibration/sounds.Device was built using IC TL071 and555 timer IC.Standard Piezo sensor is used todetect any vibration due to pressurechange.LED’s used to detect the output.Piezo buzzer is used to indicate thepressure change.Concept: Whenever a pressurechange develops near the sensor, thecircuit will be activated.

Digital Hearing AidDesigned a circuit for a low-costgeneral purpose electronichearing aid.Circuit designed using an audioamplifier IC TDA2822M – forportable low power application;Audio output is 10 – 15 mWTransistor BC 547, condensermicrophone and an LED toindicate the power status.Device designed to consume lowpower.

PAPERS PRESENTED

NEURAL ENGINEERING• Wrote a conceptual paper on combining two methods – EEG and fMRI to aid in understanding of the pathophysiological mechanisms of epileptic discharges.• Peer reviewed and presented the journal paper – Prism Adaptation in the rehabilitation of patients with visuo-spatial cognitive disorders (Laure Pisella, et al.,)

ARTIFICAL PANCREAS• Presented a conceptual paper on integrating continuous glucose monitors & insulin pumps with an algorithm to provide insulin in the desired quantity at the required time. This concept can be elaborated as an external artificial pancreas for continuous monitoring of blood glucose levels in the human body. Goals of the paper: i) to improve insulin replacement therapy. ii) ease of burden of therapy for the insulin dependent.

INTERN PROJECTSAGAR APOLLO HOSPITAL, BANGALORE, INDIA

CLINICAL EQUIPMENTS• Correlated information about functioning of clinical equipments like Biochemistry analyzers, Ventilators, Defibrillators, X-Ray, MRI and dialyzers to theoretical concepts.• Assisted engineers in troubleshooting and preventive maintenance• Coordinated in communicating with doctors to extract, write and develop design and functional specifications (DS/FS) for implant requirements.

Prathiba Portfolio 2010

by prathi02

Accessibility

Upload Details

Usage Rights

1 Embed 17

Statistics