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  1. 1. Clinical Databases : MEDLINE S.Prasanth Kumar Dept. of Bioinformatics Applied Botany Centre (ABC) Gujarat University, Ahmedabad, INDIA Sivakumar FOLLOW ME ON ACCESS MY RESOURCES IN SLIDESHARE prasanthperceptron CONTACT ME [email_address]
  2. 2. <ul><li>MEDLINE is the U.S. National Library of Medicine's® (NLM) premier bibliographic database that contains over 18 million references to journal articles in life sciences with a concentration on biomedicine. </li></ul><ul><li>A distinctive feature of MEDLINE is that the records are indexed with NLM Medical Subject Headings  (MeSH®) </li></ul><ul><li>Selection of journals for MEDLINE are based on </li></ul><ul><li>Recommendation of the Literature Selection Technical Review Committee ( LSTRC ), an NIH-chartered advisory committee of external experts analogous to the committees that review NIH grant applications </li></ul><ul><li>NLM-initiated reviews which are special priorities for NLM or other NIH components (Topics covered: history of medicine, health services research, AIDS, toxicology and environmental health, molecular biology, and complementary medicine) </li></ul>MEDLINE
  3. 4. MeSH is the National Library of Medicine's controlled vocabulary thesaurus. It consists of sets of terms naming descriptors in a hierarchical structure that permits searching at various levels of specificity. MeSH descriptors are arranged in both an alphabetic and a hierarchical structure. Most general level : very broad headings. e.g. &quot;Anatomy&quot; or &quot;Mental Disorders.&quot; More specific headings : more narrow levels of the twelve-level hierarchy e.g. &quot;Ankle&quot; and &quot;Conduct Disorder.&quot; There are 26,142 descriptors in 2011 MeSH. There are also over 177,000 entry terms that assist in finding the most appropriate MeSH Heading, for example, &quot;Vitamin C&quot; is an entry term to &quot;Ascorbic Acid.&quot; MESH keywords
  4. 5. MESH Applications The MeSH thesaurus is used by NLM for indexing articles from 5,400 of the world's leading biomedical journals for the MEDLINE®/PubMED® database . It is also used for the NLM-produced database that includes cataloging of books, documents, and audiovisuals acquired by the Library. Each bibliographic reference is associated with a set of MeSH terms that describe the content of the item. Similarly, search queries use MeSH vocabulary to find items on a desired topic. MEDLINE is the primary component of  PubMed ® , part of the Entrez series of databases provided by the NLM National Center for Biotechnology Information (NCBI). MEDLINE may also be searched via the  NLM Gateway
  5. 6. Details of MEDLINE Time coverage : generally  1946 to the present , with some older material. Source : Currently, citations from approximately 5,516 worldwide journals in 39 languages; 60 languages for older journals. Citations for MEDLINE are created by the NLM,  international partners , and collaborating organizations. Updates : Since 2005, between 2,000-4,000 completed references are added each day Tuesday through Saturday; nearly 700,000 total added  in 2010 . Broad subject coverage : The subject scope of MEDLINE is biomedicine and health, broadly defined to encompass those areas of the life sciences, behavioral sciences, chemical sciences, and bioengineering needed by health professionals and others engaged in basic research and clinical care, public health, health policy development, or related educational activities. MEDLINE also covers life sciences vital to biomedical practitioners, researchers, and educators, including aspects of biology, environmental science, marine biology, plant and animal science as well as biophysics and chemistry. Increased coverage of life sciences began in 2000.
  6. 7. MEDLINE Searching
  7. 8. MEDLINE Searching
  8. 9. MEDLINE Searching
  9. 10. MEDLINE Searching
  10. 11. MEDLINE Searching
  11. 12. MEDLINE Standard Concept View
  12. 13. MEDLINE Navigating from Tree Top
  13. 14. MEDLINE Navigating from Tree Top
  14. 15. NLM Classification System
  15. 16. NLM Classification System
  16. 17. Understanding NLM Classification System (Taken Pharmacology as Example)
  17. 18. Understanding NLM Classification System (Taken Pharmacology as Example)
  18. 19. Understanding NLM Classification System (Taken Pharmacology (Anti-Inflammatory Agents) as Example)
  19. 20. NLM
  20. 21. NLM AND boolean operator necessary Why?
  21. 22. Searching Strategies
  22. 23. Clinical Trials
  23. 24. Information on Clinical Trials
  24. 25. Information on Clinical Trials