Nicotinic receptors
Acetyl Co enzyme A and Choline.

NM
Location

Function

NN

Central N

Skeletal NMJ All autonamic
Sens...
M1 (Neuronal
and gastric)

M2 (Cardiac)

M3(Glandular)

M4

M5

Distrib Ganglia, gastric
ution parietal cells,
CNS (cortex...
CENTRAL NERVOUS SYSTEM

PARASYMPATHETIC

Brain

Contracts pupil III
Stimulates salivation VII
Spinal
cord

Constricts bron...
Parasympathomimetics
Directly acting

Indirectly acting

1. Ach

2. Synthetic choline esters

Reversible

Methacholine
Car...
Anger, Alert,
Aggressive
Mydriasis

Inc. Muscle tone

Flushing of Face
Bronchodilatation
In. Cardiac output

Liver
Glucoge...
Tyrosine→Dopa→Dopamine→NEpi→Epi
ANS Cholinergic
ANS Cholinergic
ANS Cholinergic
ANS Cholinergic
ANS Cholinergic
ANS Cholinergic
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ANS Cholinergic

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ANS Cholinergic

  1. 1. Nicotinic receptors Acetyl Co enzyme A and Choline. NM Location Function NN Central N Skeletal NMJ All autonamic Sensory nerve post synaptic ganglia and terminals adrenal medulla presynaptically Contraction NE & E from Facilitate of Sk. muscle adrenal medulla release of Dopamine, glutamate Mechanism Ligand gated Ligand gated channel channel
  2. 2. M1 (Neuronal and gastric) M2 (Cardiac) M3(Glandular) M4 M5 Distrib Ganglia, gastric ution parietal cells, CNS (cortex, hippocampus) Myocardium, smooth muscle, presynaptic PNS,CNS Exocrine glands, visceral smooth muscle, vascular endothelium Neostriatum Substanti a nigra Functi on Gastric acid secretion, GI motility, CNS excitation SA node rate of impulse generation AV node velocity and decrease atrial and ventricular contraction Exocrine secretions. Smooth muscle contraction (expect urinary, Blood vessels - - Mech G protein (Gq), IP3,DAG,depolari zation Gi cAmp, opening of K+ channels G protein (Gq), IP3,DAG,depolari zation Gi cAmp, opening of K+ channels G (Gq), IP3,DAG, depolariz Agoni st Oxotremorine Methacholine Bethanechol - - Anta gonist Pirenzepine, Telenzepine Methoctramine,Tripi 4-DAMP, Hexa tramine hydrosiladifenidol
  3. 3. CENTRAL NERVOUS SYSTEM PARASYMPATHETIC Brain Contracts pupil III Stimulates salivation VII Spinal cord Constricts bronchi X Slows heartbeat X Stimulates activity Stimulates gallbladder Gallbladder Contracts bladder Stimulates erection of sex organs S
  4. 4. Parasympathomimetics Directly acting Indirectly acting 1. Ach 2. Synthetic choline esters Reversible Methacholine Carbachol Bethanechol Carbamates 1. Natural alkaloids 3. Natural alkaloids 2. Quaternary • Muscarine • Nicotine • Pilocarpine • Arecoline 4.Miscellaneous • Tremorine • Oxotremorine • Physostigmine • Edrophonium • Neostigmine • Pyridostigmine • Ambenonium • Demecarium • Rivastigmine Acridine Tacrine Irreversible 1. Organophosphates • Ecothophate • Isoflurophate • Paraoxon • Parathion • Malathion • Diazon 2. Carbamates • Popoxour • Carbaryl
  5. 5. Anger, Alert, Aggressive Mydriasis Inc. Muscle tone Flushing of Face Bronchodilatation In. Cardiac output Liver Glucogenolysis More energy prod Large B vessels dilate to speed up blood flow Lipolysis-Energy
  6. 6. Tyrosine→Dopa→Dopamine→NEpi→Epi

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