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BOS-Bio-Programming environment

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BOS-Biological Operating System - Looking for funding to create the first of its kind - Biological Visual programming Environment which will be easy to use by biologists who are not computer savvy/ …

BOS-Biological Operating System - Looking for funding to create the first of its kind - Biological Visual programming Environment which will be easy to use by biologists who are not computer savvy/ NOT programming savvy but are driven by biological research queries.

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  • 1. Helix Genomics HELIX GENOMICS
  • 2. BOS – Biological Operating System Helix Genomics Prasad Burra, Ph.D Founder, MD & CTO programming life Helix Genomics
  • 3. protein DNA mutant Drug Discovery phase (5-7Y) 8-1 $1.3B Helix Genomics HELIX GENOMICS Market pain Science
  • 4. Market pain : Software
    • Not 'systems biology' ready
    • One algorithm – one tool
    • Tools not scalable, extensible
    • Tools are scattered
    • No flowchart or process automation
    • Enormous unproductive time – searching , learning, customizing, benchmarking
    • No standardization
    • No integration
    • Data Redundancy
    Restrictive Helix Genomics
  • 5. Novel BOS paradigm The Researcher Custom data Best Results Output
    • 'systems biology' ready
    • One-language solution
    • Biological design & intuitive
    • Customizable, extensible and flexible
    • Flowchart or process automation
    • On-the-fly biological programming – no compilation, no linking
    • Rich source of reusable and tested biological objects
    • Easy testing, validation and benchmarking
    • Cuts cost and time by ~55%
    • Scientific exploration & inquiry
    • Faster & alternative solutions
    • Process / Flowchart implementation
    • Reliable, Reusable & Consistent
    • Application Frameworks
    Helix Genomics Our Solution:'a must have'
  • 6. ...The analytical software segment .. posting .. fastest growth rate... Global Bioinformatics Market Outlook, Research Report, Sept 2007 Evolving bioinformatics software Competitive Matrix Helix Genomics 1 st Gen 2 nt Gen 3 ed Gen 4 th Gen 1970- -- 1980-- 2000- -- 2002- -- Functions ( Sequence Comparison) Tools Like Blast Accelrys Bio perl / Bipjava Helix Genomics / Bos Integration / Visualization 0 10 10 10 programming & Automation 0 10 3 8 ( customization, scripting, extensibility) 0 0 6 10 Biological design implementatin 0 0 1 10
  • 7. BOS – one-stop, one-language solution
      • Standardization is possible with BOS which is mentioned as a major challenge in recent market reports
    GBMO, Research Report, Sept 2007 Integration / Visualization Biological Design Programming & Automation Biological Functions Helix Genomics
  • 8. Market size
    • Bioinformatics tools - market size:
    • The bioinformatics market is forecast to grow at a CACR of 23% to $4.5bn by 2011
    • Market segmentation
      • Database providers – 45% (2006) - $US 0.8b
      • Drug Discovery research – 55% - $US 1.0b
    • Genomics – 60%
    • Proteomics – 40%
    Helix Genomics GBMO, Research Report, Sept 2007
  • 9. Market growth ...it is the analytical software segment that is posting the fastest growth rate ... ( Global Bioinformatics Market Outlook, RNCOS, Sept 2007) ‏ Helix Genomics Market Category 1980 2002 2005 Data Suppliers 49% 38% 30% Analytical Software Providers 39% 43% 55% Enterprise System Providers (Accelrys etc…) ‏ 12% 19% 15%
  • 10. Target market
    • Drug Discovery research Co's
      • Pharmaceutical
      • Biotech
      • Life Science
    Academia Helix Genomics Source: Nature Biotechnology, 2000
  • 11. Target size
    • Bioinformatics R&D and Educational Establishments*
    Helix Genomics *Estimates based on 'Growing the Nation's Bioscience sector:, BIO, April 2006 USA Europe India Total Degree Colleges/ Post Graduate Centers 1250 1070 2000 4670 Engineering Colleges/Universities/Depts. 350 Research Institutes/Labs 2050 1850 75 3975 Biotech /Life Science Cos 1120 990 20 2130 Pharma Cos/CROs 1580 1320 30 2930 Total 6000 2530 2475 13705
  • 12. Technology Licensing Contract Services
      • Contract Research Service and Outsourcing
        • Custom biological databases
        • Custom algorithms,
        • custom software tools
    Drug discovery, genomic, proteomic & HT data analysis Product Service Online bioinformatics lab Helix Genomics Revenue models
  • 13. Current Status Helix Genomics HELIX GENOMICS
  • 14. Growth & Sustainability Patent Protected Technology Exploitation Product Road Map BioVPE ‏ BOS Client/Server BOS Online Bio SDK ‏ Helix Genomics BOS on Cloud Computing/ GRID/ Mobile / Parallel
  • 15. Exit strategy Helix Genomics HELIX GENOMICS
  • 16. BOS – Biological Operating System programming life Helix Genomics
      • Goal : BOS on every PC (in 10 years) ‏
        • Google of Bioinformatics (Internet market) ‏
        • Microsoft of Bioinformatics (PC market) ‏
  • 17. Helix Genomics Additional Slides
  • 18. BOS –Data curation through analysis to publishing
    • 500 Biological Objects
    • 15000 methods/functions
    • 25 Algorithm Implementation
    • 15 Database Input formats
    • 3 Output formats
    • 7 Biological Libraries
    • Several Sequence and Structure
    • specific objects
    • Statistics and Matrix functions
    • 300,000 lines of Code
    • Dynamic Intelli Help
    • Programmatic interface for connecting
    • to databases
    Protein Prediction Algorithms Protein Homology modeling Genome wide analysis Helix Genomics HELIX GENOMICS Encouraging Innovation, Enabling Expression of Biological Intuition
  • 19. Technically me
    • 2.5 years in Web Designing –
    • Wikis, Web CMSs using AJAX – [X|D]HTML, CSS, Javascript, MySQL, PHP
    • 4 years of teaching & training in Bioinformatics & Computational Biology
    • 6 years of entrepreneurial activity –
    • Director / Founder / CEO / CTO
    • 12 years of research into Bioinformatics, Bio-software, Genomics, Proteomics, Systems Biology
    • 15 years of Programming –
      • C++ / Shell Scripting / *nix OS /
    Helix Genomics
  • 20. Excerpts supporting BOS timing
    • ...it is the analytical software segment that is posting the fastest growth rate...( Sept 2007) ‏
    • ...lack of standardization remain the biggest challenge for the bioinformatics industry...(Sept 2007)
    • ... outsourcing is expected to emerge as a definitive trend in the bioinformatics industry, according to a new report by Frost & Sullivan(Sep, 06)
    • ...if the tools are put in the hands of the actual users , the entire user base will increase , making it an attractive proposition for the bioinformatics companies...(Aug 05) ‏
    • it is necessary to capture the student/academic community first...(Oct, 05) ‏
    • the market for bioinformatics isn't large enough to support a company built around one or two high-cost software programs targeted to a relatively small user group...(Nov, 04)
    Helix Genomics
  • 21. BOS programming guide : Helix Genomics BOS programming guide:
  • 22. Life Cycle of Biological Query
    • Data Generation (Experimental)‏
    • Data Processing Tools
    • Data Reduction Tools
    • Data Annotation Tools
    • Data Mining Tools
    • Data Analysis Tools
    • Data Representation Tools
    • Data Publishing Tools
    Domain of a Computational Biologist With BOS one can accomplish all these computational tasks and queries Helix Genomics
  • 23. BOS Algorithms – Generic Object Oriented Biological Algorithms - GOOBA Self Repeat Algo. Helix Genomics Encouraging Innovation, Enabling Expression of Biological Intuition.