Anti aging with holistic approach


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Anti aging with holistic approach

  1. 1. StemRx Bioscience Solutions Dr. Pradeep Mahajan Stem Cells Transplant Expert | Founder @ StemRx Bioscience Solutions, India
  2. 2. You carry your own natural repairing kits in your own body
  3. 3. Aging and death do seem nature has planned for us... The questions is Can we slow down this process? Develop clock of aging Time.. 3
  4. 4. They fought for “amrut” … become immortal 4
  5. 5. "the land of the immortals" OKINAWA 5
  6. 6. “Mankind is always in search of how to prolong life & above all, to make old age worth living & purposeful…” Everyone 6 wants to live longer and look younger
  7. 7. Aging ?- How we age Breakdown in the cellular safety nets Functional decline of molecular, cellular activities to multiple organ level Decrease in the vitality of the body to adopt various diseases Decrease in the reproductivity Death is the Final event 7
  8. 8. Aging / Senesces Causes of Aging Geneti c | DNA Damag e Free radical metabolis m AGEs (Advanced Glycation End Products) Telomer s Gene of Aging daf2 Gene of longetivity  Aging reflects over all body with different pace  Aging does not occur in same way in every human being 8 Lifestyle, genetic make up has influence on aging
  9. 9. Organ/ function Blood WBC and RBC count decreases Face / skin Wrinkles, facial hair, thinning cheek, double chin Hair Graying, thinning, balding Bones Loss of bone cells as they become porous and brittle Muscles Loss of muscular mass Fat Fat content and distribution change, storage increases Joints 9 Aging Symptoms Cartilage becomes cracks and frays
  10. 10. Therapy Cognitive Behavirol Therapy(W C Bushwell 2006) What  Enhancing Self    10  healing capacities Mobilization of dormant or sleeping stem cells Activate body immune system Decreasing Free radicals Link between How  Diet – Veg & Fruits,      Green Tea Workout, Meditation, Breathing Exercises Coping the stress Calorie Restrictions Antioxidants Growth hormone supplements
  11. 11. Average lifespan with Aging diseases 11
  12. 12. Death Causes 12
  13. 13. So the question is can we stop aging An Adult Human once a tiny cell, is a self assembling machine made of trillions of microscopic components… 13
  14. 14. Lets see what are the ways ??? Gene Therapy – Narrow Bandwidth Cell Therapy – Broad Bandwidth 14
  15. 15. How to Delay or Reverse The Aging? Antiaging  Remove the damage or Inactive molecules and cells  Restore function to several molecules by repair & Replacement  Modify the Genetic Program to prevent the aging process from continuing How are we going to do Above changes...??? 15
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  17. 17. Who Can take Anti-Aging Treatment  Absolutely healthy aging (King of Good Times)  Patients with age related diseases (Struggler King)  Aging patients with serious & Advanced diseases (Bankrupt King) 17
  18. 18.  Aging can be reversed by set of cells at a laboratory level??? Do you believe ? 18
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  21. 21. Stem cells proportion with aging How the aging reflects in this graph? 21 growing cells > apoptic cells (Child) Growing cells = apoptic cells (Mature person) Growing Cells < apoptic cells (Aging Starts) “Aging has been linked to age related inabilities of stem cells
  22. 22. 22 Stem Cells Therapy for Antiaging Source : Life Extension Magazine Ju
  23. 23. What makes given stem cells to reach to target/damaged site?  Hypoxia  SDF1  HGF  Platelets  MSC are magic cells as they release plethora of natural factors like chemokines and cytokines as well the microenvironment is equally responsible. 23
  24. 24. THE ADVANTAGES Of Stem Cell Anti-Aging Treatment            Stem Cells from your own body are used No chemicals or drugs are needed Better breathing and sleeping pattern. Energy levels restored Age spots fade Complexion brightens and skin softens No more expensive supplements or creams required Hormones are re-balanced Sugar levels controlled Heightened sexual drive Increased metabolism and surprisingly an average 4-7 kg weight loss.  Hair color darkening and volume increasing.  There is also a better control of blood pressure and improved vision  Emotional and cognitive improvement occurs, memory 24 improves, concentration ability increases and your ability to
  25. 25. Future Enhancements New Cutting Edge Technologies 1. VSEL 2. High Telomerase activity cells 3. Therapeutic application of cloned cells 25
  26. 26. VSEL VSEL : Very Small Embryonic/ Epiblast-like stem cells 26 Potentially represent the most regenerative adult stem cells having embryonic characterization. Proposed as a viable alternative to human embryonic stem cells. They home to site of injuries, upregulate angiogenesis, down
  27. 27. First reported in mouse bone marrow in 2006 by Kucia M characterized by CXCR4(+)SSEA-1(+)Oct-4+ markers. Later identified in human blood and bone marrow as well. In 2011 Sovalat H supported the evidence of presence of VSEL in human bone marrow. These relevant cells might be issued from very small embryonic-like stem cells deposited in the BM during ontogenesis and reside lifelong in the adult BM, and that they could be mobilized into peripheral blood by granulocyte colony-stimulating factor. very small embryonic-like stem cells constitute a "mobile" pool of primitive/pluripotent stem cells that could be released from the BM into the peripheral blood under the influence of various physiological or pathological stimuli like injuries, hypoxia, physical exercises etc. 27
  28. 28. 1. Studies have shown that VSEL’s are deposited in adult tissues as backup population for TCSC 2. An increase in chronic caloric uptake may prematurely deplete VSELs from adult tissues, thus contributing to aging. By contrast, caloric restriction has an opposing beneficial effect on the tissue-residing pool of VSELs and longevity. 28
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  30. 30. Isolation of VSEL’s from blood by aphaeresis Injection of purified VSEL’s in body Followed by GCS factor mobilization Characterizat ion and enrichment Mixed with collagen sponge scaffolds 30
  31. 31. References 1. Kucia M, Reca R, Campbell FR, Zuba-Surma E, Majka M, Ratajczak J, Ratajczak MZ, (2006) A population of very small embryonic-like (VSEL) CXCR4(+)SSEA-1(+)Oct-4+ stem cells identified in adult bone marrow. Leukemia. May;20(5):857-69. 2. Ratajczak MZ, Zuba-Surma EK, Machalinski B, Ratajczak J, Kucia M. (2008), Very small embryonic-like (VSEL) stem cells: purification from adult organs, characterization, and biological significance.Stem Cell Rev.,4(2):8999. doi: 10.1007/s12015-008-9018-0. Epub 2008 May 6. 3. Heider A, Danova-Alt R, Egger D, Cross M, Alt R. (2013),Murine and human very small embryonic-like cells: a perspective. Cytometry A.;83(1):725. doi: 10.1002/cyto.a.22229. Epub 2012 Nov 16. 31 4. Sovalat H, Scrofani M, Eidenschenk A, Pasquet S, Rimelen V, Hénon P (2011) Identification and isolation from either adult human bone marrow or G-CSFmobilized peripheral blood of CD34(+)/CD133(+)/CXCR4(+)/ Lin(-)CD45(-) cells, featuring morphological, molecular, and phenotypic characteristics of very small embryonic-like (VSEL) stem cells. Exp Hematol. Apr;39(4):495505. doi: 10.1016/j.exphem.2011.01.003.
  32. 32. 5. Aaron M. Havens, Yusuke Shiozawa, Younghun Jung, Hongli Sun, Jincheng Wang, Samantha McGee, Anjali Mishra,L. Susan Taichman,Theodora Danciu,Yajuan Jiang,Gregory Yavanian,Elizabeth Leary,Paul H. Krebsbach,Denis Rodgerson,and Russell S. Taichman, Human Very Small Embryonic-Like Cells Generate Skeletal Structures, In Vivo; STEM CELLS AND DEVELOPMENT Volume 00, Number 00, 2012 Mary Ann Liebert, Inc. DOI: 10.1089/scd.2012.0327 32
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