Recent trends in pharmaceutical packaging


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The pharmaceutical packaging market is constantly advancing and has experienced annual growth of at least five per cent per annum in the past few years. The market is now reckoned to be worth over $20 billion a year. As with most other packaged goods pharmaceuticals need reliable and speedy packaging solutions that deliver a combination of product protection, quality, tamper evidence, patient comfort and security needs. Constant innovations in the pharmaceuticals themselves (such as prefilled syringes, blow fill seal vials, powder applications and others) also have a direct impact on the packaging.

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Recent trends in pharmaceutical packaging

  1. 1. RECENT TRENDS IN PHARMACEUTIC AL PACKAGING By Mr.Prashant Patel Department of pharmaceutical technologyIndukaka Ipcowala college of pharmacy
  2. 2. Why Packaging development is needed?  In India, pharma packaging today stability and occupies a significant portion of shelf life to the the overall drugs market. drug  Earlier, the requirements of convenience pharma packaging focusedand compliance exclusively on preserving the of drug use. quality of enclosed medication. to ensuring  Now, they are extended to cover product safety such criteria:  prevention of product tampering and counterfeitingBrand identity  assurance of product dispensing accuracy  promotion of patient compliance with product dosage schedules.
  3. 3. stability and shelf life to the drug Reckitt Benkiser launched the easily portable Handy Tube version of its popular Strepsils line of sore throat lozenges. The new packaging is not only convenient to carry, but at the same time provides adequate humidity protection to the product during its shelf life.
  4. 4. convenience and compliance of drug use.Moov - pain reliever by ParasPharmaceuticals now bought over by.Reckitt Benckiser. It was earlier available intubes; but it is now also available as anaerosol spray which is convenient, easy toapply and ideal for people on the move.
  5. 5. Brand identity“ The packaging contains coding by whichconsumers can connect via smart phone to productcontent in addition to what they can already see on adrugs label, printed packaging and inserts. Themanufacturing and packaging contractor sees thetechnology as a way to give clients products a leg upon crowded retail shelves” - Catalent Pharma
  6. 6. Major influences are: Product trends influencing pack trends Changes and trends in packaging materials Changes in packaging processes
  7. 7. Current market scenario Global pharma packaging industry studies show that by 2011 pharma packaging industry was expected to grow by 5.9 percent per annum and was predicted to reach $34 billion mark within 2011. While as per a McKinsey report, Indian pharma packaging is expected to reach $50 billion by 2015. Nano technology, The global market for nano-enabled packaging for blisters was $941 million in 2008 and is expected to grow to $2.10 billion by 2014.
  8. 8. Different trends  Sustainability  Cost effective  Robots in primary packaging - ESS Technology and FUNAC system  Radio-frequency identification(RFID)  Electronic-Enabled Packaging  Unit-dose packaging for greater dosage control  Packaging against counterfeiting  Child-resistant packaging  Eco-friendly pharma packaging  The Talking Packaging : “Self Talk”  Dispensing Caps
  9. 9. Sustainability waste- reduction Recycling of imperatives of packing the last material environmental era minimizing greenhouse-gas sourcing of generation, wate renewable r use, and materials energy consumption.
  10. 10. Cost effective Chennai - based company Jumbo Bags who after intensive R&D developed bags with corrugated linings weights capacity-500 kgs to 2000 kgs. it could be folded when not in use which was not possible while using drums. Price-drum costs Rs 120 to Rs 150. for 30 drums, the total cost would be Rs 3600. The bag manufactured by Jumbo Bags would cost only Rs 2500. Robots (and robot-like devices) also increase flexibility of packaging equipment, decrease time consumption, increase output and reduce labor cost.
  11. 11. Robots in primary packaging -ESS Technology and FUNAC system the LR Mate - standard platform for the TaskMate. Motion control, high speed and robotic dexterity makes it suitable for product orientation, collation, and repetitive tasks. Capable of speeds above 40 picks per minute. the TaskMate can count, stack, load, or unload medical devices, pouches, and other related items.
  12. 12. Radio-frequency identification(RFID) RFID tagging to simplify shipping, receiving, inventory location, and control has been mandated by the Department of Defense, several other retailers, and various hospitals. carry and collect the data needed to track and trace product through the supply chain prevent counterfeiting and diversion coupled with sensors to monitor conditions during shipping and storage and provide alerts if parameters are exceeded. to monitor patient compliance. Tagged blisters record when doses are taken ("Med-ic" electrical compliance monitor, Information Mediary
  13. 13.  Dual-function tags - RFID with temperature sensing, having cost less than traditional devices for temperature monitoring e.g. integrates a sensor, microchip, battery, and antenna on a paper-thin label.13.56 MHz ("TempSens" smart label, KSW- Microtec, Dresden, Germany. This type of smart sensor label–equipped blister package is being used by the National Institutes of Health (Bethesda, MD), for a multiyear study of chronic obstructive pulmonary disease that will involve nearly half a million individual doses of medication.
  14. 14. Electronic-Enabled Packaging In February 2011, Finnish packaging company Stora Enso unveiled the newest iteration of its adherence control packaging, Pharma DDSi Wireless. This technology is based on conductive ink on a carton board- based blister inlay, which is Stora Ensos new Pharma connected to a cellular module DDSi Wireless packaging embedded in the package. leverages cellular networks The removal of pills is tracked to track patient adherence data, allowing reminders to and the information can be sent be sent by text. to an electronic database automatically via GSM or GPRS
  15. 15.  Catalents Delpouch Starter Kit packaging system, designed for topical treatments. Delpouch measures the right amount of topical cream or ointment to simplify the application process. Catalents Media Enhanced Packaging technology, which allows patients to scan a digitally embedded watermark in the packaging with their smartphones to access extra product information, videos or even real-
  16. 16. Cypaks advanced medication Packaging can now connect withmonitoring and report card computers using sensor, can record the time and allowing patients to log theirdate that a pill was taken based on feedback on side-effects andwhen it is removed from its blister treatment efficacy and upload it.
  17. 17. Unit-dose packaging for greaterdosage control Aim:-"With more of a focus on outpatient care and the self-regulation of medicine, theres greater onus on patients to take the right medications in the right amount" A January 2012 study by US-based market research firm Freedonia suggests “unit-dose formats, including vials, ampoules, prefillable syringes and premixed IV solutions, are some of the biggest growth drivers of the aseptic packaging market.” In fact, prefillable syringes are predicted to represent the fastest growing aseptic packaging type, with demand expected to grow 11% each year to $1.1bn.
  18. 18. Bosch Packaging Technologyrecently acquired the machinerybusiness of Eisai, a Japan-basedleader in filling single doses.
  19. 19. Packaging against counterfeiting AS per FDA - counterfeit drugs account for 10% of all medication in the US EU believes between 1% and 3% of medicines latest developments are fluorescent labels, packaging with laser surface authentication, which can be identified through a unique code, and near field communication (NFC) tags. In India for instance, drug companies have been sending their medicines to overseas markets including an obligatory sport barcode on their outermost packaging, started in October 2011.
  20. 20. Child-resistant packaging Keeping drugs secure from young children while ensuring user-friendliness to seniors is one of the main objectives of pharmaceutical packaging companies. Child-resistant (CR) packaging was introduced in the late 1960s and early 1970s, and is most commonly known as a safety cap on bottles that has to be pushed down before being opened. More advanced CR packaging, such as special blister packs and cardboard packaging, has only been released onto the market in the last decade, and looks set to continue its growth in the future as its popularity increases.
  21. 21.  Packaging company Amcor Flexibles followed suit a few years later and introduced a CR blister pack, the Guardlid, which is compliant to CR / senior friendly (SF) regulations in Europe and the US.
  22. 22.  UK packaging producer Burgopaks sliding CR blister pack can only be opened by applying pressure at two separate points on the packaging. The blister pack and information leaflets are integrated with the outer box, which ensures the product is never separated from its packaging. Burgopak Healthcare & Technology - won the award for the ‘Most Innovative Child Resistant Packaging Design’ at the Pharmapack Paris exhibition on 16th February 2012.
  23. 23.  In 2006, Stora Enso and Bosch Packaging launched Pharma small hands resistant (SHR), a re-closable and tear-resistant carton ideal for highly toxic drugs, which TestPak, lnc. started using and producing the same year.
  24. 24. Eco-friendly pharma packaging Environmental considerations must not lead to any compromise on a packages safety or accessibility. New pharmaceutical packaging concepts are beginning to emerge that address environmental concerns without sacrificing packaging advances made in the last decade.
  25. 25.  In August 2011, Keystone Folding Box Company and Legacy Pharmaceutical Packaging launched their Ecoslide-RX sustainable compliance packaging. The pack is made from 100% recycled material, using unbleached paperboard and a clay-coated surface designed to house blister packaging with a minimum of unsustainable film and foil. The slide package meets all the modern expectations for child-resistance and accessibility for seniors, but doesnt require heat sealing in the manufacturing process, reducing
  26. 26. Syreen prefilled syringe design Environmental awareness is even starting to extend to the syringe market. Syreen syringes replace glass with cyclic olefin polymer (COP), this material has allowed Cambridge consultant to jettison secondary packaging altogether as the COP design forms its own outer shell. The ability of packed syringes to clip into place also eliminates the need for packing materials like styrofoam and cardboard. Packaging weight reduction - 30% and volume - 50%, compared to
  27. 27. Cyclo olefin polymer (COP) Lightweight breakage-resistant packaging for protein-based peptide-based, floating particle, and high-viscosity drugs suitable for use in prefilled syringes and vials where transparency, sterilization, breakage- resistance, and stability are important mechanical properties of devices made from COP have no significant change after steam-, ethylene oxide-, and gamma-sterilization Zeon Chemicals L.P., a wholly owned sub. of Zeon Corp.
  28. 28. The Talking Packaging : “Self Talk” There are two developments in talking packaging at this moment  The “TalkPack” from Wipak Walsrode GmbH in Germany, a system, which can be invisibly integrated into any printed image on any packaging material, but needs a special scanning pen  a recent development by VTT Technical Research Centre of Finland using tags with NFC (Near Field Communication) based technology connected to NFC-enabled mobile phones to download text, audio or web page product information, which can be played back on their handset.
  29. 29. Talk Pack-Wipac A special pen-shaped reader is used to retrieve the stored information and to replay it as audio files and render speech, music or sounds audible and thus the consumer can obtain information on the manufacturer, brand, shelf-life or other information. Talk Pack does not require any RFID or microchips. the dot code is simply printed on top of images and texts using a special varnish. This technology can be used with all printing technologies and
  30. 30. NFC tags - VTT Technical Research Centre NFC tags are added to any packaging so a consumer could touch the code on the packaging with their NFC-enabled mobile phone to download text, audio or web page product information, which can be played back on his handset. provided spoken dosage instructions from pharmacy staff, to aid a visually impaired or blind person. Currently, the number of mobile phones with NFC technology is
  31. 31. Dispensing Caps dispensing caps or functional caps - store dry or liquid supplements separately from the water - released by the consumer they form an energy or vitamin drink or sometimes a medicinal drink. everything from pharmaceuticals to nutraceuticals, from anti- aging to anti-oxidants, from vitamins to functional supplements, from male potency to stem cell stimulants, from energy to relaxation and so on can be packed and properly dosed by a dispensed cap. it is generally claimed that pills and capsules have a very short window of absorption Liquid absorption is much higher: around 80-90%. It would more preferred especially when it comes to children
  32. 32. One of the most basicdesigns in a patent filed in2002 by inventor StephenCarlson and assigned to TheCoca-Cola Company.
  33. 33.  A typical dispenser cap includes a space which holds the substance to be dispersed (vitamin, flavour, medicine in powder form, liquid or tablet), which is bounded and sealed on one side by a membrane. A membrane opening device is used, often activated by depression of a flexible diaphragm, which causes the membrane opening device to pierce the membrane, thus enabling mixing of the contents of the dispenser with those of the container to which it is attached.
  34. 34. Recent changes and development inInhalers (MID, pMID, DPI, nebulizers) Hydrofluoroalkane (HFA) propellant replacing the chlorofluorocarbon (CFC) due to concerns about the latter’s damaging effect on the ozone layer. The US Food and Drug Administration (FDA) has ruled that no CFC MDIs will be sold in the US after 2008. As a result of the requirement to use HFA propellants, challenges arose with respect to re- designing formulation, valves, and actuators and conducting clinical trials. The elastomeric components in existing metering valves are generally incompatible with HFA propellants, and some surfactan
  35. 35.  DPI devices are categorized as single-unit dose inhalers in which each dose is loaded into the device before use (Aerolizer™, Novartis; Handihaler™, Boehringer Ingelheim) multidose reservoir inhalers in which a large supply of drug is pre-loaded into the device (Turbuhaler™ or Flexhaler™, Astra Zeneca; Twisthaler™, Schering- Plough) multiunit dose inhalers in which several single doses are individually sealed and discharged each time the device is actuated (Diskus™, GlaxoSmithKline).
  36. 36.  The Aerolizer uses separate single-dose capsules while the Flexhaler, Diskus, and Twisthaler all have dose indicators. In contrast, pMDIs do not have an independent means by which to monitor the number of doses remaining in the device. In March 2003, the FDA issued guidelines that recommended manufacturers integrate a dose-counting device into new pMDIs (
  37. 37. Aeroneb® Solo nebulizer The Aeroneb® Solo nebulizer is designed to operate in-line with standard ventilator circuits and mechanical ventilators. Operated without changing patient ventilator parameters. Refilled without interrupting ventilation. Operated on its internal rechargeable battery for up to 45 minutes when fully charged. Operates without compressed gas, making it suitable for portable applications
  38. 38. Aeroneb Pro The Aeroneb Pro is a reusable, multi-patient use nebulizer which is suitable for hospital environments where the appropriate sanitization facilities are available. Cost-Effective:  Negligible residual volume in medication cup, so minimizes drug waste  Multiple patient use  Autoclavable at 132ºC - 135ºC (270ºF - 275ºF) Flexible:  Operates in-line with standard ventilator circuits  off-vent with an aerosol mask or a mouth piece  Accessorized to treat for infant thorugh to adult
  39. 39. Aero Chamber plus Flow-Vu-Monaghan Medical Corporation; marketed by ForestLaboratories
  40. 40. Diskus Inhaler Technique Device innovators and manufacturers were honored as AANMA’s first innovative technology award at the 15th annual Allergy & Asthma Day Capitol Hill on Thurs., May 10, 2012. A DISKUS® is a dry-powder inhaler that holds 60 doses. It features a built-in counter, so that you always know how many doses you have left in it. First dry powder inhaler that simplifies asthma care by combining an inhaled corticosteroid with a long-acting bronchodilator in one device.- GlaxoSmithKline
  41. 41. References Chapter 17,packaging of pharmaceutical dosage forms, Gilbert S. Banker, Christopher T. Rhodes,pg. Dr. John Green, Dr. Erik Gommeren, PHARMACEUTICAL AEROSOLS – ENHANCING THE METERED DOSE INHALER, DuPont Central Research & Development. Shyam Sunder B K, Pharmaceutical packaging - A growing phenomenon, pecial03.shtml Dvaczek, Tracking Growth Trends, Pharmaceutical & Medical Packaging News, March 2010, Volume 18, No. 3 pharmaceutical-packaging-carton-cartons-paper-packaging-whit packaging
  42. 42. References trends-for-2011.aspx# Trends in pharmaceutical packaging, SigPack Systems, Trends/ArticleStandard/Article/detail/407882 trends-and-anti-counterfeiting-initiatives/