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anemia classification

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anemia classification

anemia classification

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     anemia classification anemia classification Presentation Transcript

    • -Definition -Classification ANEMIA By: Tassaya Kanyook ID:52112158
      • ANEMIA IS NEVER NORMAL
      • Men: HGB < 13.5 or HCT < 41%
      • Women: HGB < 12.0 or HCT < 36%
      WHAT IS ANEMIA?
      • Definition of Anemia
      • Anemia is a decrease in the RBC count, Hgb and/or HCT values as compared to normal reference range for age and sex
      • (Also determined by alteration in plasma volume)
    •  
    • CLASSIFICATION OF ANEMIAS 1 2
    • CLASSIFICATION OF ANEMIAS 1
    • CLASSIFICATION OF ANEMIAS
      • Hb levels decreased
      • MCV normal
      • Acute blood loss
      • Anemia of chronic disease
      • Aplastic anemia
      • Hemolytic anemia
      • size of erythrocytes is larger than normal
      • Megaloblastic anemia – Vitamin B12, Folate deficiency.
      • size of erythrocytes is smaller than normal
      • Heme synthesis defect
        • Iron deficiency anemia
        • Anemia of chronic disease
      • Thalassemia
      • Sideroblastic anemia
      2
    • NORMOCYTIC NORMOCHROMIC ANEMIA
      • It includes
          • Aplastic anemia due to BM failure
          • Blood loss anemia
          • Hemolytic anemia
      • Is a condition in which the size & Hgb content of RBCs is normal but the number of RBCs is decreased.
    • MICROCYTIC- HYPOCHROMIC ANEMIA
      • Many RBCs smaller than nucleus of normal lymphocytes
      • Increased central pallor.
      • Includes
        • Iron deficiency anemia
        • Thalassemia
        • Anemia of chronic disease
        • Sideroblastic anemia
        • Lead poisoning
      • Is a condition in which the total body iron content is decreased below a normal level
      • This results in a reduced red blood cell and hemoglobin production
      IRON DEFICIENCY ANEMIA (IDA)
      • Inherited decrease in alpha or beta globin chain synthesis needed for Hgb A; quantitative defect
        • All have microcytic/hypochromic RBCs and target cells
      • Genetic mutations classified by:
        • ↓ beta chains = beta thalassemia…Greek/Italian
        • ↓ alpha chains = alpha thalassemia…Asian
      THALASSEMIAS Target cells/Codocytes Beta Alpha
    • MACROCYTIC NORMOCYTIC ANEMIAS
      • A. MEGALOBLASTIC ANEMIA
          • Vitamin B12 deficiency
          • Folate deficiency
          • Abnormal metabolism of folate and vit B12
      • B. Non megaloblastic anemia
          • Liver disease
          • Alcoholism
          • Post splenoctomy
          • Neonatal macrocytosis
          • Stress erythropoiesis
      Wright’s stained blood smear
      • Macrocytosis due to a deficiency of vitamin B12 or folic acid that causes impaired nuclear maturation
      MEGALOBLASTIC ANEMIA RBC maturation in microcytic anemias…IDA Normoblastic RBC maturation  normocytic red cells Megaloblastic RBC maturation  macrocytic red cells
      • http://themedicalpost.net/2010/07/18/the-general-concept-of-anaemias /
      • http:// accessmedicine.com/search/searchAMResult.aspx?rootterm=anemias&searchType=1&rootID=64&searchStr=anemia&modifier=yes&subID=180
      • http:// en.wikipedia.org/wiki/Thalassemia
      • http:// www.medicinenet.com/anemia/article.htm
      REFERENCES