“NANOMEDICINA. La Última Frontera”                           Chemistry: Contributions to                                Cl...
Nanomedicine             20th Century Research based on the discovery of new         molecular entities (APIs) Analgesics ...
Nanomedicine     Drug therapies based in targeted/controlled               drug delivery systems              Drug        ...
Nanomedicine  Ideal Nanocarriers as Drug Delivery Systems (DDS)                 Multifunctional nanobjects                ...
Nanomedicine            Novel Drug Delivery Systems  Nanoparticles     Polymeric-drug         VesciclesNanosuspensions    ...
New Methods to Prepare Particulate Drug Delivery Systems      Using compressed CO2 as a green solvent                     ...
New Methods to Prepare Particulate Drug Delivery Systems      Using compressed CO2 as a green solvent                     ...
Processing of a drug for bronquial asthma Salmenterol xinafoate (SX)                          Drug for inhalatory asthma t...
Processing of an antibiotic for resistent infectionsGentamicine loaded in bioadhesive nanostructured polymer as           ...
Integration of Bioactive Principles into Nanovesicles                                   Integration on surface &          ...
Integration of Bioactive Principles into Nanovesicles                                   Cholesterol          CTAB         ...
Scaling-up the DELOS methodology6 mL system          300 mL system             2000 mL system 25mL                   1250m...
Scaling-up the DELOS methodology                         E. Elizondo, Doctoral Thesis, 2010
Nanomedicine                                    AcknowledgmentsCo-workers:Dr. Nora Ventosa, Dr. Santi Sala, Dr. Maria Munt...
AcknowledgementsMolecular Nanoscience             AcknowledgmentsThank you for your attention.......
Jaume Veciana - Chemistry: Contibutions to Clinical Therapeutics
Jaume Veciana - Chemistry: Contibutions to Clinical Therapeutics
Jaume Veciana - Chemistry: Contibutions to Clinical Therapeutics
Jaume Veciana - Chemistry: Contibutions to Clinical Therapeutics
Jaume Veciana - Chemistry: Contibutions to Clinical Therapeutics
Jaume Veciana - Chemistry: Contibutions to Clinical Therapeutics
Jaume Veciana - Chemistry: Contibutions to Clinical Therapeutics
Jaume Veciana - Chemistry: Contibutions to Clinical Therapeutics
Jaume Veciana - Chemistry: Contibutions to Clinical Therapeutics
Jaume Veciana - Chemistry: Contibutions to Clinical Therapeutics
Jaume Veciana - Chemistry: Contibutions to Clinical Therapeutics
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Jaume Veciana - Chemistry: Contibutions to Clinical Therapeutics

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Chemistry: Contibutions to Clinical Therapeutics

By Jaume Veciana

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Jaume Veciana - Chemistry: Contibutions to Clinical Therapeutics

  1. 1. “NANOMEDICINA. La Última Frontera” Chemistry: Contributions to Clinical Therapeutics Jaume Veciana vecianaj@icmab.es www.expoquimia.com
  2. 2. Nanomedicine 20th Century Research based on the discovery of new molecular entities (APIs) Analgesics Antibiotics Cancer treatmentKeys: chemical synthesis, molecular and bioactivity characterization
  3. 3. Nanomedicine Drug therapies based in targeted/controlled drug delivery systems Drug (therapeutic action) Polymeric capsule (pharmacological features)Nanocarrier Drug Delivery System Increasing the therapeutic efficiency of drugs….
  4. 4. Nanomedicine Ideal Nanocarriers as Drug Delivery Systems (DDS) Multifunctional nanobjects Components Functions Container Protector Targeting Magnetic particle Diagnosis Drug TherapyPreparation of drug delivery systems at the nanoscale with scale-up methods P. Couvreur et al., Pharm. Res., 2006, 23, 1417-1450.
  5. 5. Nanomedicine Novel Drug Delivery Systems Nanoparticles Polymeric-drug VesciclesNanosuspensions conjugates Liposomes
  6. 6. New Methods to Prepare Particulate Drug Delivery Systems Using compressed CO2 as a green solvent  Non-toxic  Non-flammable  Cheap  Easy separated from products  Enabling to control particles  Scale-up methods J.J. Watkins et al., Science 2004, J.D. Holmes et al. Chem. Eur. J. 2003
  7. 7. New Methods to Prepare Particulate Drug Delivery Systems Using compressed CO2 as a green solvent Vescicles Liposomes Polymeric-drug conjugates Nanoparticles Nanosuspensions DELOS-family processes
  8. 8. Processing of a drug for bronquial asthma Salmenterol xinafoate (SX) Drug for inhalatory asthma treatment OH NH2+HO HO O OH CO2 - Bioavailable 12 Non-bioavailable % Volume 8 4 0 0.1 1 10 100 Particle Size (µm)
  9. 9. Processing of an antibiotic for resistent infectionsGentamicine loaded in bioadhesive nanostructured polymer as microparticles 2,5 µm Oral DeliveryE. Elizondo et al, Pharm. Res., 2011, 28, 309-321
  10. 10. Integration of Bioactive Principles into Nanovesicles Integration on surface & inside of the nanovesicles Compressed CO2 Integration Encapsulation
  11. 11. Integration of Bioactive Principles into Nanovesicles Cholesterol CTAB CO2 small molecules Bioactive macromoleculesSpin-off at PRUAB:
  12. 12. Scaling-up the DELOS methodology6 mL system 300 mL system 2000 mL system 25mL 1250mL 8300mL X 50 X6 E. Elizondo, Doctoral Thesis, 2010
  13. 13. Scaling-up the DELOS methodology E. Elizondo, Doctoral Thesis, 2010
  14. 14. Nanomedicine AcknowledgmentsCo-workers:Dr. Nora Ventosa, Dr. Santi Sala, Dr. Maria Muntó, Dr. Mary Cano, Dr. ElisaElizondo, Alba Cordoba, Ingrid Cabrera, Dr. Miquel Gimeno, Daniel Villanueva,Dr. Evelyn Moreno, Dr. Imma Ratera, Dr. César Diez-Gil, Witold Tatkiewicz Financial support:Collaborations:• Prof. Marcel Besnard (LPCM-CNRS, France)• Dr. Cristina Patiño (CNB-CSIC, Madrid)• Dr. Jordi Esquena (CID-CSIC, Barcelona)• Dr. Sylvane Lesieur (CNRS, France)• Prof. Antoni Villaverde (UAB)• Dr. Simó Schwartz (Hospital Vall D´Hebrón)• Dr. Maria Blanco (U. Navarra)• Dr. Maria Parajo (IBEC, Barcelona)• Prof. Joel Bernstein (Israel)• Dr. Dimitrios Stamou (Denmark)• Dr. Eduardo Martínez Díaz, (CIGB, Cuba)
  15. 15. AcknowledgementsMolecular Nanoscience AcknowledgmentsThank you for your attention.......

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