Desco, Manuel - Virtual planning for IOERT: radiance

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INNOVATION CAPSULES: Track 2: Tecnologías para la transformación del sistema sanitario

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Desco, Manuel - Virtual planning for IOERT: radiance

  1. 1. Virtual planning for IOERT:radiance®Manuel DescoDpto. Bioingeniería e Ingeniería Aeroespacial, UC3MHospital General Universitario Gregorio MarañónCoordinador Red ITEMASdesco@hggm.es
  2. 2. Outline  Intraoperative Radiation Therapy Planning Workstation: radiance®  The problem and the solution  How did we do it?  Key points
  3. 3. IOERT: Definition Radiotherapy during cancer surgery Normal tissue protection (physical displacement) Minimal tumor burden
  4. 4. The problem with IOERT  Patient anatomy changed  Difficult dosimetry estimation  Distrust, lack of confidence
  5. 5. The solution A Surgery – Radiotherapy planning workstation which:  Works on preoperative images - Simulates surgery - Deals with elastic anatomy changes  Simulates application insertion  Estimates dosimetry  May work on real-time intraoperative / radiation session imaging studies
  6. 6. Radiance® IEORT 2D - 3D planning Dosimetry estimation
  7. 7. IOERT Planning Workflow Segmentation Simulation Dosimetric pre-planningDefine regions  Simulate the  Select applicator parameters Organs to patient position,  Dose estimated with PB protect orientation and surgical access  Treatment energy defined with High risk areas the help of DVHs for different regions
  8. 8. First prototype: 1997No company found until 2006
  9. 9. radiance: IP Patent  PCT/ES2008/000240  WO 2009/127747 A1 Agencia medicamento (2011) FDA approval (2012)
  10. 10. Validation Real patient during CT study
  11. 11. Snowball growing  Projects and partners  Several industrial projects (2006-2013): PROFIT, IMADE, INNPACTO (“PRECISION”).  2 clinical evaluation projects (ETES, ISCIII)  Growing consortium : Universities  Hospitals Industrial • Complutense of Madrid (nuclear physics) • Gregorio Marañón (Madrid) • GMV (Madrid) • Granada (physics) • Castellón (Castellón) • TRF (Zaragoza) • Madrid Politechnical (biomedical imaging) • Ramón y Cajal (Madrid) • Valencia (robotics) • La Luz (Madrid) • San Jaime (Alicante)
  12. 12. radiance: on-going work
  13. 13. Key points Clinical initiative  Solving a real problem  Creates new market  No competence Finding a company: A hard job  Long times involved until success Technology transfer vs. PPP

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