Harvard-MIT Biomedical Engineering Center                   Innovation at MIT:The Center,What is     Examples of translati...
Harvard-MIT Biomedical Engineering Center                                                                  FROM           ...
Harvard-MIT Biomedical Engineering Center                                              What we have learned:• Train studen...
Harvard-MIT Biomedical Engineering Center              • Advance human health through academic excellence                i...
Harvard-MIT Biomedical Engineering Center                                                                      EDUCATION  ...
Harvard-MIT Biomedical Engineering Center                                                                      RESEARCH   ...
Harvard-MIT Biomedical Engineering Center                                      TISSUE ENGINEERED ENDOTHELIAL CELLSAllogene...
Harvard-MIT Biomedical Engineering CenterSTRUCTURE/FUNCTION RELATIONSHIP                                                  ...
Harvard-MIT Biomedical Engineering CenterMECHANOTRANSDUCTION                                                              ...
Harvard-MIT Biomedical Engineering CenterMODELS OF HEALTH AND DISEASE                               77 Massachusetts Avenu...
Harvard-MIT Biomedical Engineering Center                                                                          ACHIEVE...
Harvard-MIT Biomedical Engineering Center                                                   “MIT INNOVATION ECOSYSTEM”    ...
Harvard-MIT Biomedical Engineering Center    Deshpande Center (2002)     • Gift of $17.5MM from Desh and       Jaishree De...
Harvard-MIT Biomedical Engineering Center           Spinouts               Active Spectrum                            Tes...
Harvard-MIT Biomedical Engineering Center                                                    “MIT INNOVATION ECOSYSTEM”   ...
MISTIMISTI – MITInternational Scienceand TechnologyInitiatives - is MITsprimary internationalprogram.MISTI connects MITs...
MISTInetwork in               Brazil China14 countries   Switzerland                                 Chile                ...
MISTI Internships abroad700600500400300200100 0
Harvard-MIT Biomedical Engineering Center                                         Today MIT-Spain is 5.5                1 ...
Harvard-MIT Biomedical Engineering Center                            Brigham and Women’s Hospital                         ...
Harvard-MIT Biomedical Engineering Center                                              What we have learned:• Train studen...
Harvard-MIT Biomedical Engineering Center       This work has been possible thanks to the support from          Ministerio...
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Balcells, Mercedes - Innovation at MIT: Examples of translational research and internationalization

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Track 1: Conocimiento clínico y gestión de la innovación: de la idea al mercado
1.1. El proceso de la innovación

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Balcells, Mercedes - Innovation at MIT: Examples of translational research and internationalization

  1. 1. Harvard-MIT Biomedical Engineering Center Innovation at MIT:The Center,What is Examples of translational researchuniqueabout it?- Education and internationalization- Research Mercedes Balcells, PhD- Industry- International Research MIT Scientist, Harvard-MIT Biomedical Engineering Center Professora Titular, Institut Químic de Sarrià77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA 1
  2. 2. Harvard-MIT Biomedical Engineering Center FROM 3. Hosting 1-2 international students at MIT FROM TO1. Studying structure-function Pervasis, Inc (Cambridge, US) ?relationship in a blood vessel A Medical device engineering (stents, sensors,2. Studying mechanotransduction balloons…)pathways C D (Barcelona, Spain) TO A MIT-Spain 77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA 2
  3. 3. Harvard-MIT Biomedical Engineering Center What we have learned:• Train students to carry their engineering and scientific expertise from thelaboratory bench to the patients bedside and to bring clinical insights from thepatients bedside to the laboratory bench.• Establish partnerships that facilitate collaborations across disciplines andleverage the strengths of multiple institutions.• A change in paradigm - from “pure” research to innovation - requiresdeveloping an innovation ecosystem that promotes entrepreneurship; this doesnot happen in a year or two.• Internationalize, internationalize, internationalize 77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA 3
  4. 4. Harvard-MIT Biomedical Engineering Center • Advance human health through academic excellence in education and research that integrates science, engineering and medicine. • Educate outstanding minds, cultivate leaders, create knowledge, and generate cost-effective preventative, diagnostic, and therapeutic innovations.77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA 4
  5. 5. Harvard-MIT Biomedical Engineering Center EDUCATION MD, PhD Programs Harvard Train students to carry their engineering and scientific expertise from the laboratory US Harvard-MIT bench to the patients bedsideAcademia BMEC and to bring clinical insights from the patients bedside to the US MIT laboratory bench. Hospitals 40MD, 15PhD, 5MD/PhD, 5MBA “teaches you how medical doctors think and how they talk” Kay Furman, HST PhD candidate77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA 5
  6. 6. Harvard-MIT Biomedical Engineering Center RESEARCH Harvard Investigators have special access to both universities world-class resources and to Harvard Medical Schools teaching hospitals. US Harvard-MIT BMEC This partnership facilitatesAcademia collaborations across disciplines US and leverages the strengths of MIT Hospitals multiple institutions. As a result, our researchers accomplish more than they could independently.77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA 6
  7. 7. Harvard-MIT Biomedical Engineering Center TISSUE ENGINEERED ENDOTHELIAL CELLSAllogeneic EC CELL NUMBER/105 10 8 6 41 x 4 x 0.3cm3 Matrix 2 0 0 7 14 TIME (days) Viability Assay Viability Ox-LDL AcLDL Uptake 77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA 7
  8. 8. Harvard-MIT Biomedical Engineering CenterSTRUCTURE/FUNCTION RELATIONSHIP Intima (Endothelium) Connective tissue Media (Smooth Muscle) VASCULAR REPAIR Adventitia (Fibroblasts) Paracrine regulation of arterial repair in vivo Ox-LDL Viability 77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA 8
  9. 9. Harvard-MIT Biomedical Engineering CenterMECHANOTRANSDUCTION ENVIRONMENT MATTERS 77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA 9
  10. 10. Harvard-MIT Biomedical Engineering CenterMODELS OF HEALTH AND DISEASE 77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA 10
  11. 11. Harvard-MIT Biomedical Engineering Center ACHIEVEMENTS Smart hardware EKG, monitors Harvard Intensive care unit medicine Space medicine Software Hospital and clinical Harvard-MIT Integrated functional biology BMEC Devices Drugs US MIT Gene therapy Hospitals US Tissue and cell engineering Industry77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA 11
  12. 12. Harvard-MIT Biomedical Engineering Center “MIT INNOVATION ECOSYSTEM” SEBC Enterprise MIT Sloan I-Teams Forum Academia $700 million VCPE 100Kresearch/year competition Enterpreneurship Deshpande Center Center Industry MIT TLO MIT VMS Commercial Enterprise77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA 12
  13. 13. Harvard-MIT Biomedical Engineering Center Deshpande Center (2002) • Gift of $17.5MM from Desh and Jaishree Deshpande • Have raised additional $4MM since from donors, corporations • Grants: - 500 proposals - 72 projects - $11+MM grants • Results: - 200+ faculty/students - 100+ volunteers (catalyst program) - 22 start-ups + 1 license - Capital >$180 MM77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA 13
  14. 14. Harvard-MIT Biomedical Engineering Center Spinouts  Active Spectrum Test Equipment  Beam Power Amplifiers for Wireless  Brontes(3M) Dental Imaging  ERC Titanium production  Entra Drug delivery  Hepregen Drug Discovery  Molecular Stamping Nano Production  Myomo Stroke Rehabilitation  Pervasis Tissue Repair  Pufco Secure Processors  QD vision Displays  Sentina Auto Sensors  Taris Biomedical Drug Delivery  1366 Solar Cells  Vertica Database Software77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA 14
  15. 15. Harvard-MIT Biomedical Engineering Center “MIT INNOVATION ECOSYSTEM” SEBC Enterprise MIT Sloan I-Teams Forum Academia $700 millionInternational? VCPE International? 100K research/year competition Enterpreneurship Deshpande Center Center Industry MIT TLO MIT VMS International? International? Commercial Enterprise 77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA 15
  16. 16. MISTIMISTI – MITInternational Scienceand TechnologyInitiatives - is MITsprimary internationalprogram.MISTI connects MITstudents and facultywith research andinnovation around theworld. MIT International Science and Technology Initiatives
  17. 17. MISTInetwork in Brazil China14 countries Switzerland Chile Spain Russia France Mexico Germany Korea India Japan Italy Israel
  18. 18. MISTI Internships abroad700600500400300200100 0
  19. 19. Harvard-MIT Biomedical Engineering Center Today MIT-Spain is 5.5 1 4 170 14 55 18 70years partner sponsors “host” events projects professors visitors 321 14 STRATEGIC PARTNER La Cambra de Barcelona MIT-SPAIN SPONSORS HOST INSTITUTIONS Fundació Empreses IQS La Cambra de Barcelona (~50) La Caixa Posimat77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA 19
  20. 20. Harvard-MIT Biomedical Engineering Center Brigham and Women’s Hospital Prof. Vacanti Harvard-MIT Biomedical Engineering Center Agata Gelabertó Prof. Edelman, Dr. Balcells Albert Milé - Boston - Sant Joan de Déu Dr. Claveria/Dr. Parri - Barcelona - The Vanderbilt Bill Wilkerson Center Dr. Eavey - Nashville-77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA 20
  21. 21. Harvard-MIT Biomedical Engineering Center What we have learned:• Train students to carry their engineering and scientific expertise from thelaboratory bench to the patients bedside and to bring clinical insights from thepatients bedside to the laboratory bench.• Establish partnerships that facilitate collaborations across disciplines andleverage the strengths of multiple institutions.• A change in paradigm - from “pure” research to innovation - requiresdeveloping an innovation ecosystem that promotes entrepreneurship; this doesnot happen in a year or two.• Internationalize, internationalize, internationalize 77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA 21
  22. 22. Harvard-MIT Biomedical Engineering Center This work has been possible thanks to the support from Ministerio de Ciencia e Innovación (BFU2009--‐09804) The Barcelona Chamber of Commerce Fundació Empreses Institut Químic de Sarrià Posimat Special thanks to MIHealth Committee and Fira de Barcelona … and an open invitation to collaborate with us77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA 22

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