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X zen platinum

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FDA warns the consumers not to use X zen platinum a product claiming that it's a herbal sexual stimulant, on 10th june 2013.

FDA warns the consumers not to use X zen platinum a product claiming that it's a herbal sexual stimulant, on 10th june 2013.

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X zen platinum X zen platinum Presentation Transcript

  • FDA warns against“X Zen Platinum”P.Naina MohamedPharmacologist
  • IntroductionThe Food and Drug Administration (FDA) isadvising consumers not to purchase or use“X Zen Platinum,” a product promoted andsold for sexual enhancement on variouswebsites, including www.ebay.com and insome retail stores, on 10thJune 2013.FDA laboratory analysis confirmed that “X ZenPlatinum” contains sildenafil and tadalafil,the active ingredients in the FDA-approvedprescription drugs Viagra and Cialis,respectively, used to treat erectiledysfunction (ED).
  • Possible Mechanism ofActionX Zen PlatinumContains undeclared sildenafil and tadalafilInhibition of Phosphodiesterase 5 (PDE 5)Inhibition of Breakdown of cGMPIncrease the concentration of cGMP in smooth muscle ofcorpus cavernosum and penile arteriesSmooth muscle relaxationIncrease the blood flow to corpus cavernosumPenile Erection
  • Interaction with NitratesUndeclared ingredients (sildenafil and tadalafil)Interact with prescription drugs like nitrates(Nitroglycerin)Excessive dilation of smooth muscle of bloodvesselsLower blood pressure to dangerous levelsHypotensionHeart Attack
  • Other InteractionsUndeclared ingredients (sildenafil andtadalafil)Interacts with Alpha adrenergic blockers, otherantihypertensives or CYP3A4 enzymeinhibitors like Ketoconazole, Erythromycin,RitonavirLower blood pressure to dangerous levelsHypotension
  • ConclusionFDA warns the Consumers should stop using this productimmediately and throw it away.FDA advises the Consumers who have experienced anynegative side effects should consult a health careprofessional as soon as possible.FDA announces to the public of a growing trend of dietarysupplements or conventional foods with hidden drugsand chemicals. These products are typically promotedfor sexual enhancement, weight loss, and body building,and are often represented as being “all natural.”FDA claims that they are unable to test and identify allproducts marketed as dietary supplements on the marketthat have potentially harmful hidden ingredients.FDA advises the Consumers to exercise caution beforepurchasing any product in the above categories.
  • References http://www.fda.gov/Drugs/ResourcesForYou/Consumers/BuyingUsingMedicineSafely/MedicationHealthFraud/ucm355895.htm Goodman & Gilmans The Pharmacological Basis ofTherapeutics, 12eLaurence L. Brunton, Bruce A. Chabner, Björn C. Knollmann Harrisons OnlineFeaturing the complete contents of Harrisons Principles ofInternal Medicine, 18eDan L. Longo, Anthony S. Fauci, Dennis L. Kasper, Stephen L.Hauser, J. Larry Jameson, Joseph Loscalzo, Eds. Hursts The Heart, 13eValentin Fuster, Richard A. Walsh, Robert A. Harrington Basic & Clinical Pharmacology, 12eBertram G. Katzung, Susan B. Masters, Anthony J. Trevor Clinicians Pocket Reference, 11eLeonard G. Gomella, Steven A. Haist
  • References http://www.nlm.nih.gov/medlineplus/druginf http://www.rxlist.com/cialis-tadalafil/drug-2.h http://www.medicinenet.com/tadalafil/article.htm http://www.drugs.com/tadalafil.html