Voluntary recall of 72 hp, evil root and pro power max
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Voluntary recall of 72 hp, evil root and pro power max

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Hardmenstore.com recalled the products such as 72HP, Evil Root and Pro Power Max due to the content of undeclared ingredient Sildenafil.

Hardmenstore.com recalled the products such as 72HP, Evil Root and Pro Power Max due to the content of undeclared ingredient Sildenafil.

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Voluntary recall of 72 hp, evil root and pro power max Voluntary recall of 72 hp, evil root and pro power max Presentation Transcript

  • Voluntary Recall of 72HP, Evil Root and Pro Power Max P. Naina Mohamed Pharmacologist
  • Introduction  On 27th Aug 2013, Upon request of the FDA, Hardmenstore.com is voluntarily recalling 1000 lots of 72HP, Evil Root and Pro Power Max at the consumer level.  FDA analysis found 72HP, Evil Root and Pro Power to contain amounts of the PDE-5 Inhibitor, sildenafil.  Sildenafil is approved for erectile dysfunction (ED) and is not listed on the product labels.  Sildenafil may interact with nitrates found in some prescription drugs such as nitroglycerin and may lower blood pressure to dangerous levels.  Consumers with diabetes, high blood pressure, high cholesterol, or heart disease often take nitrates.  The products may cause side effects, such as headaches and flushing.
  • Possible Mechanism of Action 72HP, Evil Root and Pro Power Max Contain Sildenafil Inhibition of Phosphodiesterase 5 (PDE 5) Inhibition of Breakdown of cGMP Increase the concentration of cGMP in smooth muscle of corpus cavernosum and penile arteries Smooth muscle relaxation Increase the blood flow to corpus cavernosum Penile Erection
  • Interaction with Nitrates Undeclared ingredient (Sildenafil) Interact with prescription drugs like nitrates (Nitroglycerin) Excessive dilation of smooth muscle of blood vessels Lower blood pressure to dangerous levels Hypotension Heart Attack
  • Interaction with Antihypertensives Undeclared ingredient (Sildenafil) Interacts with Alpha adrenergic blockers and other antihypertensives Lower blood pressure Hypotension
  • Interaction with CYP3A4 inhibitors Undeclared ingredient (Sildenafil) CYP3A4 enzyme inhibitors like Ketoconazole, Erythromycin, Ritonavir Lower blood pressure Hypotension
  • Adverse Effects  Jack Rabbit may cause side effects, such as headaches and flushing. Jack Rabbit Contains undeclared Sildenafil and Tadalafil Inhibition of Phosphodiesterase 5 (PDE 5) Vasodilation Headache and Flushing
  • Conclusion  These products are marketed as a dietary supplement for sexual enhancement.  Customers who have these products in their possession should stop using it immediately and contact their physician if they have experienced any problems that may be related to taking this product.  FDA announces to the public of a growing trend of dietary supplements or conventional foods with hidden drugs and chemicals. These products are typically promoted for sexual enhancement, weight loss, and body building, and are often represented as being “all natural.”  FDA claims that they are unable to test and identify all products marketed as dietary supplements on the market that have potentially harmful hidden ingredients.  FDA advises the Consumers to exercise caution before purchasing any product in the above categories.
  • References  http://www.fda.gov/Safety/Recalls/ucm366506.htm?source=govdeliver y&utm_medium=email&utm_source=govdelivery  http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsfo rHumanMedicalProducts/ucm366524.htm  Goodman & Gilman's The Pharmacological Basis of Therapeutics, 12e Laurence L. Brunton, Bruce A. Chabner, Björn C. Knollmann  Harrison's Online Featuring the complete contents of Harrison's Principles of Internal Medicine, 18e Dan L. Longo, Anthony S. Fauci, Dennis L. Kasper, Stephen L. Hauser, J. Larry Jameson, Joseph Loscalzo, Eds.  Hurst's The Heart, 13e Valentin Fuster, Richard A. Walsh, Robert A. Harrington  Basic & Clinical Pharmacology, 12e Bertram G. Katzung, Susan B. Masters, Anthony J. Trevor  Clinician's Pocket Reference, 11e Leonard G. Gomella, Steven A. Haist
  • References  http://www.nlm.nih.gov/medlineplus/drug info/meds/a699015.html  http://www.rxlist.com/viagra- drug/clinical-pharmacology.htm  http://www.medicinenet.com/sildenafil/a rticle.htm  http://www.pfizer.com/files/products/uspi _viagra.pdf