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FDA issued a warning against Reload a herbal sexual stimulant, on 10th june 2013.

FDA issued a warning against Reload a herbal sexual stimulant, on 10th june 2013.

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Reload Reload Presentation Transcript

  • FDA warns against“Reload”P.Naina MohamedPharmacologist                                                  - 
  •    IntroductionThe Food and Drug Administration (FDA) isadvising consumers not to purchase or use“Reload,” a product promoted and sold forsexual enhancement on various websites,including www.reloadpill.com1 and in someretail stores. , on 10thJune 2013.FDA laboratory analysis confirmed that“Reload” contains sildenafil.
  • Possible Mechanism of ActionReloadContains SildenafilInhibition of Phosphodiesterase 5 (PDE 5)Inhibition of Breakdown of cGMPIncrease the concentration of cGMP in smooth muscle of corpuscavernosum and penile arteriesSmooth muscle relaxationIncrease the blood flow to corpus cavernosumPenile Erection
  • Interaction with NitratesUndeclared ingredient (Sildenafil)Interact with prescription drugs like nitrates (Nitroglycerin)Excessive dilation of smooth muscle of blood vesselsLower blood pressure to dangerous levelsHypotensionHeart Attack
  • Other InteractionsUndeclared ingredient (Sildenafil)Interacts with Alpha adrenergic blockers, otherantihypertensives or CYP3A4 enzymeinhibitors like Ketoconazole, Erythromycin,RitonavirLower blood pressureHypotension
  • ConclusionFDA warns the Consumers should stop using this productimmediately and throw it away. FDA advises the Consumers who have experienced any negativeside effects should consult a health care professional as soonas possible. FDA announces to the public of a growing trend of dietarysupplements or conventional foods with hidden drugs andchemicals.  These products are typically promoted for sexualenhancement, weight loss, and body building, and are oftenrepresented as being “all natural.” FDA claims that they are unable to test and identify all productsmarketed as dietary supplements on the market that havepotentially harmful hidden ingredients. FDA advises the Consumers to exercise caution before purchasingany product in the above categories.
  • Referenceshttp://www.fda.gov/Drugs/ResourcesForYou/Consumers/BuyingUsingMedicineSafely/MedicationHealthFraud/ucm355955.htm Goodman & Gilmans The Pharmacological Basis ofTherapeutics, 12eLaurence L. Brunton, Bruce A. Chabner, Björn C. Knollmann Harrisons OnlineFeaturing the complete contents of Harrisons Principles ofInternal Medicine, 18eDan L. Longo, Anthony S. Fauci, Dennis L. Kasper, Stephen L.Hauser, J. Larry Jameson, Joseph Loscalzo, Eds. Hursts The Heart, 13eValentin Fuster, Richard A. Walsh, Robert A. Harrington Basic & Clinical Pharmacology, 12eBertram G. Katzung, Susan B. Masters, Anthony J. Trevor Clinicians Pocket Reference, 11eLeonard G. Gomella, Steven A. Haist
  • References http://www.nlm.nih.gov/medlineplus/drugin http://www.rxlist.com/viagra-drug/clinical-p http://www.medicinenet.com/sildenafil/article.htm http://www.pfizer.com/files/products/uspi_viagra.pdf