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Get it up


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Get it up is a product sold as herbal sexual stimulant and FDA issued a warning on 10th june 2013 against Get it up.

Get it up is a product sold as herbal sexual stimulant and FDA issued a warning on 10th june 2013 against Get it up.

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  • 1. FDA warns against“Get it Up” P.Naina MohamedPharmacologist -                                                   
  • 2.    IntroductionThe Food and Drug Administration(FDA) is advising consumers not topurchase or use “Get It Up,” aproduct promoted and sold for sexualenhancement on various websites,including and in someretail stores, on 10thJune 2013.FDA laboratory analysis confirmed that“Get it Up” contains sildenafil.
  • 3. Possible Mechanism of ActionGet it UpContains SildenafilInhibition of Phosphodiesterase 5 (PDE 5)Inhibition of Breakdown of cGMPIncrease the concentration of cGMP in smooth muscle of corpuscavernosum and penile arteriesSmooth muscle relaxationIncrease the blood flow to corpus cavernosumPenile Erection
  • 4. Interaction with NitratesUndeclared ingredient (Sildenafil)Interact with prescription drugs like nitrates(Nitroglycerin)Excessive dilation of smooth muscle of blood vesselsLower blood pressure to dangerous levelsHypotensionHeart Attack
  • 5. Other InteractionsUndeclared ingredient (Sildenafil)Interacts with Alpha adrenergic blockers,other antihypertensives or CYP3A4 enzymeinhibitors like Ketoconazole, Erythromycin,RitonavirLower blood pressureHypotension
  • 6. ConclusionFDA warns the Consumers should stop using this productimmediately and throw it away.FDA advises the Consumers who have experienced anynegative side effects should consult a health careprofessional as soon as possible.FDA announces to the public of a growing trend of dietarysupplements or conventional foods with hidden drugs andchemicals. These products are typically promoted forsexual enhancement, weight loss, and body building, andare often represented as being “all natural.”FDA claims that they are unable to test and identify allproducts marketed as dietary supplements on the marketthat have potentially harmful hidden ingredients.FDA advises the Consumers to exercise caution beforepurchasing any product in the above categories.
  • 7. References Goodman & Gilmans The Pharmacological Basis ofTherapeutics, 12eLaurence L. Brunton, Bruce A. Chabner, Björn C. Knollmann Harrisons OnlineFeaturing the complete contents of Harrisons Principles ofInternal Medicine, 18eDan L. Longo, Anthony S. Fauci, Dennis L. Kasper, Stephen L.Hauser, J. Larry Jameson, Joseph Loscalzo, Eds. Hursts The Heart, 13eValentin Fuster, Richard A. Walsh, Robert A. Harrington Basic & Clinical Pharmacology, 12eBertram G. Katzung, Susan B. Masters, Anthony J. Trevor Clinicians Pocket Reference, 11eLeonard G. Gomella, Steven A. Haist
  • 8. References