Dr. P.Naina Mohamed
Pharmacologist
 On 2nd June 2014,The Food and Drug Administration
(FDA) is advising consumers not to purchase or use
“FullThrottle On De...
FullThrottle On Demand
Undeclared Propoxyphenyl sildenafil
Inhibition of Phosphodiesterase 5 (PDE 5)
Inhibition of Breakdo...
FullThrottle On Demand
Undeclared Propoxyphenyl sildenafil
Interact with prescription drugs like nitrates (Nitroglycerin)
...
FullThrottle On Demand
Undeclared Propoxyphenyl sildenafil
Interact with Protease Inhibitors like Saquinavir, Ritonavir,
I...
FullThrottle On Demand
Undeclared Propoxyphenyl sildenafil
Interact with CYP3A4 Inhibitors like Macrolide antibiotics
(Tel...
 FDA warns the Consumers should stop using this
product immediately and throw it away.
 FDA advises the Consumers who ha...
 http://www.fda.gov/Drugs/ResourcesForYou/Consumers/Buy
ingUsingMedicineSafely/MedicationHealthFraud/ucm39960
9.htm?sourc...
 http://www.micromedexsolutions.com
 http://www.nlm.nih.gov/medlineplus/dr
uginfo/meds/a699015.html
 http://www.rxlist....
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FDA’s warning against full throttle on demand

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On 2nd June 2014, The Food and Drug Administration (FDA) is advising consumers not to purchase or use “Full Throttle On Demand”.

Full Throttle On Demand is promoted and sold for sexual enhancement on various websites, including www.overstock.com, and in some retail stores.

FDA laboratory analysis confirmed that Full Throttle On Demand contains Propoxyphenyl sildenafil.

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FDA’s warning against full throttle on demand

  1. 1. Dr. P.Naina Mohamed Pharmacologist
  2. 2.  On 2nd June 2014,The Food and Drug Administration (FDA) is advising consumers not to purchase or use “FullThrottle On Demand”.  FullThrottle On Demand is promoted and sold for sexual enhancement on various websites, including www.overstock.com, and in some retail stores.  FDA laboratory analysis confirmed that FullThrottle On Demand contains Propoxyphenyl sildenafil.  Propoxyphenyl sildenafil is structurally similar to sildenafil which is approved for the treatment of erectile dysfunction (ED).
  3. 3. FullThrottle On Demand Undeclared Propoxyphenyl sildenafil Inhibition of Phosphodiesterase 5 (PDE 5) Inhibition of Breakdown of cGMP Increase the concentration of cGMP in smooth muscle of corpus cavernosum and penile arteries Smooth muscle relaxation Increase the blood flow to corpus cavernosum Penile Erection
  4. 4. FullThrottle On Demand Undeclared Propoxyphenyl sildenafil Interact with prescription drugs like nitrates (Nitroglycerin) Excessive dilation of smooth muscle of blood vessels Potentiation of Hypotensive effects Blood pressure reduced to dangerous levels Contraindicated
  5. 5. FullThrottle On Demand Undeclared Propoxyphenyl sildenafil Interact with Protease Inhibitors like Saquinavir, Ritonavir, Indinavir, Nelfinavir, Amprenavir, Fosamprenavir, Lopinavir, Atazanavir, ,Tipranavir and Darunavir Protease Inhibitors block CYP3A4-mediated sildenafil metabolism Increased plasma levels of sildenafil Increased risk of sildenafil adverse effects (hypotension, visual changes, priapism) Contraindicated
  6. 6. FullThrottle On Demand Undeclared Propoxyphenyl sildenafil Interact with CYP3A4 Inhibitors like Macrolide antibiotics (Telithromycin, Erythromycin, Clarithromycin) and Antifungals (Voriconazole, Itraconazole, Ketoconazole) CYP3A4 Inhibitors block CYP3A4-mediated sildenafil metabolism Increased plasma levels of sildenafil Increased risk of sildenafil adverse effects (hypotension, visual changes, priapism)
  7. 7.  FDA warns the Consumers should stop using this product immediately and throw it away.  FDA advises the Consumers who have experienced any negative side effects should consult a health care professional as soon as possible.  FDA announces to the public of a growing trend of dietary supplements or conventional foods with hidden drugs and chemicals. These products are typically promoted for sexual enhancement, weight loss, and body building, and are often represented as being “all natural.”  FDA claims that they are unable to test and identify all products marketed as dietary supplements on the market that have potentially harmful hidden ingredients.  FDA advises the Consumers to exercise caution before purchasing any product in the above categories.
  8. 8.  http://www.fda.gov/Drugs/ResourcesForYou/Consumers/Buy ingUsingMedicineSafely/MedicationHealthFraud/ucm39960 9.htm?source=govdelivery&utm_medium=email&utm_sour ce=govdelivery  Goodman & Gilman'sThe Pharmacological Basis of Therapeutics, 12e Laurence L. Brunton, BruceA. Chabner, BjörnC. Knollmann  Harrison's Online Featuring the complete contents of Harrison's Principles of Internal Medicine, 18e Dan L. Longo, Anthony S. Fauci, Dennis L. Kasper, Stephen L. Hauser, J. Larry Jameson, Joseph Loscalzo, Eds.  Hurst'sThe Heart, 13e Valentin Fuster, Richard A.Walsh, Robert A. Harrington  Basic & Clinical Pharmacology, 12e Bertram G. Katzung, Susan B. Masters, Anthony J.Trevor  Clinician's Pocket Reference, 11e Leonard G. Gomella, Steven A. Haist
  9. 9.  http://www.micromedexsolutions.com  http://www.nlm.nih.gov/medlineplus/dr uginfo/meds/a699015.html  http://www.rxlist.com/viagra- drug/clinical-pharmacology.htm  http://www.medicinenet.com/sildenafil/ article.htm  http://www.pfizer.com/files/products/us pi_viagra.pdf

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