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Medications for Pain and Inflammation Julio A. Martinez-Silvestrini, MD Outpatient Medical Director Physical Medicine and Rehabilitation Baystate Medical Center
Objectives ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Pain ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
More Pain ,[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object]
Pain Ladder ,[object Object],[object Object]
 
Non-Steroidal Anti-Inflammatories ,[object Object],[object Object],[object Object],[object Object]
Copyright © 2007 Elsevier Inc. All rights reserved. Figure 15.2  Inflammatory cascade and action of NSAIDs and corticosteroids. Cellular membrane injury will promote the release of phospholipids. By influence of phospholipase, phospholipids will convert into arachidonic acid which in turn converts to prostaglandins or leukotrienes mediated by cyclooxygenase or lipoxygenase, respectively.
NSAIDs ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
NSAIDs ,[object Object]
NSAID Classes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
NSAID Classes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Adverse Effects ,[object Object],[object Object]
Adverse Effects ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Acetaminophen ,[object Object],[object Object],[object Object],[object Object],[object Object]
Acetaminophen ,[object Object],[object Object]
Adverse Effects ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Tramadol ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Anti-epileptic drugs ,[object Object]
Anti-epileptic drugs ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Anti-epileptic drugs ,[object Object],[object Object],[object Object],[object Object],[object Object]
Tricyclic antidepressants (TCA) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Tricyclic antidepressants (TCA) ,[object Object],[object Object],[object Object],[object Object]
Muscle relaxants (relaxers) ,[object Object],[object Object],[object Object],[object Object],[object Object]
Muscle relaxants (relaxers) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Topical Agents ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Topical NSAIDs ,[object Object],[object Object],[object Object],[object Object],[object Object]
Topical NSAIDs ,[object Object],[object Object],[object Object]
Opiates ,[object Object],[object Object],[object Object],[object Object],[object Object]
Preferred Analgesic Agents   Hydromorphone Hydrocodone Methadone Oxycodone Oxycontin Codeine Fentanyl Patch Morphine Sulfate IR Morphine Sulfate ER  Kadian Short acting Long Acting
Protocol ,[object Object],[object Object]
Protocol ,[object Object],[object Object]
Red Flag Behavior ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Red Flag Behavior ,[object Object],[object Object],[object Object],[object Object],[object Object]
Toxicology Screen ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 

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Meds For Pain And Inflammation

  • 1. Medications for Pain and Inflammation Julio A. Martinez-Silvestrini, MD Outpatient Medical Director Physical Medicine and Rehabilitation Baystate Medical Center
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  • 9. Copyright © 2007 Elsevier Inc. All rights reserved. Figure 15.2 Inflammatory cascade and action of NSAIDs and corticosteroids. Cellular membrane injury will promote the release of phospholipids. By influence of phospholipase, phospholipids will convert into arachidonic acid which in turn converts to prostaglandins or leukotrienes mediated by cyclooxygenase or lipoxygenase, respectively.
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  • 31. Preferred Analgesic Agents Hydromorphone Hydrocodone Methadone Oxycodone Oxycontin Codeine Fentanyl Patch Morphine Sulfate IR Morphine Sulfate ER Kadian Short acting Long Acting
  • 32.
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