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Pistoia 2011 Annual General Meeting

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Presentation delivered at the annual general meeting of Pistoia members. Describes the results of board member elections, the state of the Alliance's project portfolio, progress over the past year, …

Presentation delivered at the annual general meeting of Pistoia members. Describes the results of board member elections, the state of the Alliance's project portfolio, progress over the past year, and insights from new member Constellation Technologies about why they joined the Alliance.

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  • 1. September 2011
    The Pistoia AllianceAnnual General Meeting - 2011
  • 2. 2
    Welcome
  • 3. 3
  • 4. Please mute your line unless you want to ask a question
  • 5. September 2011
    The Pistoia AllianceMinutes of 2010 AGM
  • 6. Actions from 2010 Minutes
    Action Items:
    The board will work with the Operational Team to flesh out other ideas, and will talk reach out to the wider network to further explore these ideas.
    Ashley to work with the people who proposed these projects to develop PowerPoint presentations that can be used to solicit input from board members to gauge interest.
    6
  • 7. September 2011
    The Pistoia AllianceBoard and Membership Update
  • 8. Core Board Member Change
    10 Core companies
    Bi-Annual rotation process
    AstraZeneca, BMS, GSK, Lundbeck, Pfizer, Roche agreed to continue
    1 Seat Vacant as Novartis kindly agreed to step down and
    1 Candidate – Merck & Co
                
    Decision:
    Merck & Co are duly elected to Pistoia Alliance board until 2013 AGM.
    8
  • 9. Participating Board Member Vote
    Annual Rotation Process
    14 Participating companies
    6 Seats vacant (Infosys stepped down and normal rotation process)
    7 candidates – we thank them all for standing
    Candidates:
    Frank Brown VP and CSO Accelrys
    Joe Donahue  Senior Vice President, Global Sales at Thomson Reuters Life Sciences
    Alex Drijver, CEO, ChemAxon
    Sean Eakins, Collaborations Director, Collaborative Drug Discovery
    Nicholas Lakin, Cognizant
    Alex Scheer, Director, Informatics & Knowledge Management, Merck Serono
    Michael Stapleton , General Manager, Informatics at PerkinElmer               
    Decision: Frank, Joe, Alex D, Sean, Alex S, and Michael are duly elected to Pistoia Alliance board until 2012 AGM.
    9
  • 10. Pistoia Governance
    Ramesh Durvasula BMS
    Alex DrijverChemAxon
    Frank Brown Accelrys
    Claus Stie KallesøeLundbeck
    Bryn Roberts F. Hoffmann-La Roche
    Alexander ScheerMerck Serono
    Joe Donahue Thomson Reuters
    Tom Flores GlaxoSmithKline
    ChristophBrockel Pfizer
    Jason Swift AstraZeneca
    Ingrid AkerblomMerck & Co
    Sean EakinsCDD
    Michael StapletonPerkinElmer
    BoD
    Operational Team
    Technical Committee Chair
    Michael Braxenthaler Roche External Liaison
    Ashley GeorgeGlaxoSmithKline Treasurer
    John Wise Executive Director
    Nick Lynch AstraZeneca President
    Deborah Ausman Communications
    Martyn Wilkins Company Secretary
    Vacant
    Supported by Working Group Chairs and Operational Team
    Thanks to Pierre Menard for all his contributions to Pistoia as Technical Committee Chair
    10
  • 11. Pistoia Alliance Membership
    Sept 2011
  • 12. Member Summary
    55 members
    Targets for 2011/2012:
    • Biotechs & Life Science companies
    • 13. Academics/NGOs
    • 14. CROs
    • 15. Wider Geographic coverage (Asia etc)
    Can you help with member recruitment?
    12
  • 16. September 2011
    The Pistoia AllianceProject Portfolio Review
  • 17. Sequence Services Phase 1
    Status:
    • Phase 1 achieved
    • 18. Phase 2 commenced
    Project lead: Simon Thornber GSK
    Objective
    • Define standards for the provision of secure access to pre-competitive, shared, hosted, gene sequence databases and software tools.
    Timeline & Funding
    • £200,000
    • 19. end April 2011
    Deliverables
    • Working prototype implementations demonstrated at the Pistoia Alliance User Conference April 2011
    • 20. Phase 2 launched.
    • 21. RFP published with enhanced user requirements including addressing NGS data.
    • 22. RFP responses expected 23-Sep-11
    • 23. Phase 2 PoC demonstrations at PA User Conference – April 2012
    Next steps
  • 24. Sequence Squeeze
    Status:
    • On track
    Project lead: Simon Thornber GSK
    Objective
    • Find a new algorithm/technique for compressing next-generation
    • 25. sequencing data for use in the Sequenced Services project
    • 26. £12,000 + VAT @ 20% to manage the prize
    • 27. $15,000 prize money
    • 28. April 2011 (ready for announcement at the Pistoia Alliance Users Conference)
    Timeline & Funding
    Deliverables
    • Establish competition website: http://www.sequencesqueeze.org/
    • 29. Establish a judging panel
    • 30. State-of-the-art gene sequence data compression tool
    • 31. Project launch – start Q4 2011
    • 32. Entries close end Q1 2012
    • 33. Winners to be announced at the Pistoia Alliance Annual Conference on April 2012.
    Next steps
  • 34. SESL Phase 1
    Status:
    • Phase 1 completion delayed
    • 35. Phase 2 terminated
    Project Lead: Ian Harrow, (Pfizer), Wendy Filsell, Unilever
    Objective
    • Provide a ‘push model’ for end-user access to biomedical knowledge stored in both published literature and biological database content.
    Timeline & Funding
    • £200,000
    • 36. end June 2011
    Deliverables
    • A publicly accessible demonstrator http://www.pistoia-sesl.org
    • 37. Two publications submitted end Q3 2011
    • 38. Terminate project.
    • 39. Complete demonstrator implementation
    • 40. Submit publications
    • 41. Transfer learnings to IMI Open PHACTS project
    Next steps
  • 42. ELN
    Status:
    • Project terminated after Phase 2
    Project Lead: Richard Bolton
    Objective
    • Provide a query standard to enable chemists to share information between – and to conduct searches across – different brands of ELNs without learning a plethora of search languages.
    Timeline & Funding
    • Phase 2 costs: $12,500
    • 43. Phase 2 completed
    Deliverables
    • Identified and documented use cases
    • 44. Elaborated an XML-based query standard – ready for testing
    • 45. Find resource to write and publish a paper highlighting the opportunities and challenges of ELN Query standards.
    Next steps
  • 46. VSI
    Status:
    • Phase 1 complete
    • 47. Phase 2 waiting for resources
    Project Lead: Lee Harland (Pfizer), Ian Dix (AZ)
    • Provide a focus for vocabulary creators /consumers including publishers / Academia /Pharma and SMEs
    • 48. Identify gaps in life sciences vocabulary standards space
    • 49. Stimulate co-ordinated generation of new vocabularies in precompetitive space
    Objective
    Timeline & Funding
    • December 2009 to June 2011
    Deliverables
    • Paper submitted to and accepted by Drug Discovery Today – June 2011
    • 50. Identify and seek funding from interested parties to recruit a qualified consultancy to review vocabulary activities in the Life Sciences R&D domain.
    • 51. Identify leaders across companies to maintain momentum
    • 52. Identify areas for further vocabulary development, either specific initiatives, or as elements of other Pistoia activities
    • 53. Assign priority to those areas
    Next steps
  • 54. (1) Recent Accomplishments
    (3) Issues / Discussion Points
    Sequence Services Phase II
    • RFP signed-off - available on PA public-domain web-site
    • 55. RFP launch meeting completed: 22-Jul-11
    • 56. Project Analyst – new contract agreed and signed : 29-Jul-11
    Sequence Squeeze
    • Gene Sequence Compression Prize – project named!
    • 57. Appropriately qualified company appointed to run the prize
    • 58. Contract signed
    SESL
    • Main papers in production – outlines concluded mid-July 2011
    VSI MDT Phase I
    • Paper accepted for publication (subject to changes) in “Drug Discovery Today” 28-Jun-11
    • 59. Reviewer comments addressed 21-Jul-11
    Project Portfolio Questionnaire
    • Circulated end June 2011
    • 60. Used at the 3rd Annual Lab Data Mgmt. Conf. London – June-11
    • 61. 22 Responses collated and available in basecamp
    Information Ecosystem Workshop
    • Kick-off planning meeting Thursday 7-Jul-11
    • 62. Draft agenda created
    • 63. Delegates workshop planning meeting arranged 23-Aug-11
    Sequence Services Phase II
    • Project Analyst support is required going forward
    Sequence Squeeze
    • Awaiting kick-off meeting
    SESL
    • Develop relationship with IMI OpenPHACTS project?
    ELN – Project close
    • Resource for writing up ELN project
    VSI MDT Phase II
    • Resource required - Phase II consultant
    Project Portfolio Questionnaire
    • 21 responses received – much follow-up required
    Information Ecosystem Workshop
    • 18 delegate places already signed up
    (4) Planned Activities
    Sequence Services Phase II (NGS)
    • RFP response deadline: 23-Sep-11
    Sequence Squeeze
    • Compression Algorithm prize to be launched 1-Oct-11
    SESL
    • Main papers to be submitted by end Q3 2011
    • 64. Demonstrator to be available by end Aug 2011
    • 65. Article for autumn edition of the newsletter
    VSI MDT Phase II
    • Funding for consultant to provide background for business case
    • 66. Generate and distribute RFP to qualified consultancies
    ELN
    • Publish the ELN project as a living document e.g. Source Forge
    Information Ecosystem Workshop
    • Monday 10-Oct-11 in Hanover, Germany
    (2) FY 11 - Projects in Development
  • 67. Reflections on Progress
  • 68. Pistoia Alliance Project Teams - Reflections
    Slide 21
  • 69. Pistoia Alliance Publications
    “The Pistoia Alliance - The Sequence Services Project” - Simon Thornber et al. - G.I.T. Laboratory Journal 1-2/2011
    “Need for Collaborative Technologies in Drug Discovery” - Chris L. Waller et al. Book Chapter in “Collaborative Computational Technologies for Biomedical Research” – Edited by Sean Ekins et al. Wiley May 2011
    “What are the obstacles to innovation in the Pharmaceutical Industry? The Pistoia Alliance responds” – The Pistoia Alliance – Drug Discovery World
    “Empowering Industrial Research With Shared Biomedical Vocabularies” – Lee Harland et al - Drug Discovery Today in press
    “ELNs - An Essential Productivity Tool – But Which One to Use” – John Wise - European Pharmaceutical Review - Issue 4, 2011
    22
  • 70. September 2011
    The Pistoia AllianceProject Portfolio Questionnaire Analysis
  • 71. Project Portfolio Questionnaire – Summary
  • 72. Open Question - 9
  • 73. September 2011
    The Pistoia AllianceInformation Ecosystem Workshop (IES)
    Overview
  • 74. IES Workshop: Logistics
  • 75. Agenda and Deliverables Outline
    Morning session:
    What is the IES?
    Develop common understanding on what the IES should deliver (use cases)
    Afternoon session:
    How do we get there?
    Develop a roadmap of projects and activities
    White Paper:
    The Key Concepts
    of the Information Ecosystem
    IES Roadmap:
    Projects and
    Follow-up activities
    More info at http://pistoiaalliance.org/2011-Events/infoecoworkshop.html
  • 76. September 2011
    The Pistoia AllianceViews of a new member
  • 77. “Thoughts of a new member of the Pistoia Alliance”
    Presentation to the Pistoia Alliance AGM
    Nick Trigg, CEO
    Constellation Technologies
    13th Sept 2011
    30
  • 78. Constellation Technologies
    Involvement with Pistoia
    contributing supplier since 2010
    paid up “Participating” member since 2011
    “Technology provider”
    Technology provider with technology from CERN and UK particle physics programme specialising in providing “big data and bioinformatics” expertise to industrial customers.
    Looking for partners with which to develop next generation products for bioinformatics
    Delivered solution to Pistoia “Sequence Services Phase 1”
    Partnership with Microsoft and STFC
    Demonstrated solution at the Pistoia Users Conference, Boston, April 2011
    31
  • 79. Pistoia -An alliance of interested parties
    Pharmas
    Large/medium/small
    Biotechs
    Academic institutions
    Technology providers
    Information providers
    Infrastructure providers
    32
    Demand side
    Supply side
  • 80. Objectives of Pistoia
    Fundamentally
    Make more money!
    Solve complicated problems better/faster
    How does it do that?
    Access to customers/suppliers
    Access to partners/collaborators
    Latest thinking/trends
    Opportunity to influence/direct
    33
  • 81. How to increase value for members
    More in = more out
    Keep it relevant
    Maintain momentum with innovative projects
    Work efficiently
    Same time as other events/Teleconferencing
    Raise additional funding for projects from other sources
    Government etc
    34
  • 82. How to attract new members
    It is unique
    Added value of a special interest “club”
    More customers or suppliers than normally possible
    Leverage of everything
    Money, ideas, technologies, etc
    35
  • 83. Summary
    Recognise that Pistoia is probably unique in the world
    Keep it going!
    Realise “failures” are not all bad
    Manage back into your organisations
    Don’t let it die slowly through expectation that it will die slowly
    36
  • 84. September 2011
    The Pistoia AllianceSummary
  • 85.
  • 86. Thanks for your engagement in the coming year!
    39