The possibility of tissue damage due to negative reaction of the tissue with the metal particles of the prosthesis were evident in most of the findings along with metal poisoning. Different surgeons in attendance were able to get a hold of several information coming from different studies that were presented in the said annual gathering. Read more here: http://www.depuypinnaclelawsuit.com/updates/tissue-damage-and-metallosis-most-likely-cause-of-failure-for-depuy-pinnacle-recipients/